Results 61 to 70 of about 1,094,475 (308)
The structure of Toho1 β-lactamase in complex with penicillin reveals the role of Tyr105 in substrate recognition [PDF]
, 2016 The role of the conserved residue Tyr105 in class A β-lactamases has been the subject of investigation using both structural studies and saturation mutagenesis.
Coates, L. +5 more
core +1 more source
Penicillin encephalopathy [PDF]
Postgraduate Medical Journal, 1968 Summary Five patients who developed characteristic myoclonic twitching, drowsiness and convulsions due to intravenous penicillin and cloxacillin are described. Three had poor renal function. Twenty-three reported cases of penicillin encephalopathy are reviewed and the aetiology of the syndrome is discussed.
N, Conway, E, Beck, J, Somerville
openaire +2 more sources
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
AllergiesDocumented penicillin allergies are associated with an increased risk of surgical site infections (SSIs), and first-line antibiotics (e.g., cefazolin) are associated with a lower risk of SSIs.
Hannah Crum +5 more
doaj +1 more source
Comparison of susceptibility test methods to detect penicillin susceptibility in Streptococcus pneumoniae isolates [PDF]
, 2004 The increasing prevalence of penicillin-resistant Streptococuus pneumoniae urges for fast and accurate susceptibility testing methods. This study evaluated the comparability of three commonly used techniques; disk diffusion, E-test and agar dilution, to ...
Mohd Desa, Mohd Nasir +1 more
core
Impact of antibiotics on the proliferation and differentiation of human adipose-derived mesenchymal stem cells [PDF]
, 2017 Adipose tissue is a promising source of mesenchymal stem cells. Their potential to differentiate and regenerate other types of tissues may be affected by several factors. This may be due to in vitro cell-culture conditions, especially the supplementation
Gola, Joanna +6 more
core +4 more sources
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
PBP4: A New Perspective on Staphylococcus aureus β-Lactam Resistance. [PDF]
, 2018 β-lactam antibiotics are excellent drugs for treatment of staphylococcal infections, due to their superior efficacy and safety compared to other drugs.
Chambers, Henry F +3 more
core +3 more sources
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
The effect of antibiotics on the intestinal microbiota in children - a systematic review
Frontiers in AllergyBackgroundChildren are the age group with the highest exposure to antibiotics (ABX). ABX treatment changes the composition of the intestinal microbiota.
Juliane Wurm +8 more
doaj +1 more source