Results 121 to 130 of about 835,846 (358)

Sensitivity to Penicillin Causing an Acute Abdominal Emergency [PDF]

, 1954
W.J.S. Still
openalex   +1 more source

A potential tumor suppressor role of PLK2 in glioblastoma

FEBS Open Bio, EarlyView.
PLK2 was consistently downregulated in GBM tissues. Overexpression of PLK2 in GBM cell lines U87MG and U251 reduced their tumorigenic potential and enhanced cell cycle arrest and apoptosis. Suggesting that PLK2 overexpression could potentially be leveraged as a therapeutic strategy to inhibit tumor progression and enhance apoptosis, providing new ...
Xiangping Xia, Peirui Wang, Hua Xiao, Qishan Ran, Yan Li, Shengtao Yao   +5 more
wiley   +1 more source

Acacetin reduces endoplasmic reticulum stress through the P‐eNOS/PERK signaling pathway to attenuate MGO‐induced vascular endothelial cell dysfunction

FEBS Open Bio, EarlyView.
We investigated a potential protective effect of acacetin, a naturally occurring flavonoid, against methylglyoxal (MGO)‐induced endothelial dysfunction in human umbilical vein endothelial cells and its mechanism of action. Acacetin can could inhibit MGO‐induced intracellular calcium ion influx, enhance the expression levels of phosphorylated ...
Zhen Zhang, Kaien Hu, Zhaohui Fang, Sihai Wang, Jie Chen, Dengke Yin, Caiyun Zhang, Gefei Ma   +7 more
wiley   +1 more source

Rolling the evolutionary dice: Neisseria commensals as proxies for elucidating the underpinnings of antibiotic resistance mechanisms and evolution in human pathogens

Microbiology Spectrum
Species within the genus Neisseria are adept at sharing adaptive allelic variation, with commensal species repeatedly transferring resistance to their pathogenic relative Neisseria gonorrhoeae.
Kelly M. Frost, Sierra L. Charron-Smith, Terence C. Cotsonas, Daniel C. Dimartino, Rachel C. Eisenhart, Eric T. Everingham, Elle C. Holland, Kainat Imtiaz, Cory J. Kornowicz, Lydia E. Lenhard, Liz H. Lynch, Nadia P. Moore, Kavya Phadke, Makayla L. Reed, Samantha R. Smith, Liza L. Ward, Crista B. Wadsworth   +16 more
doaj   +1 more source

Penillic Acid, an Optically Active Acid from Penicillin [PDF]

, 1943
W. M. DUFFIN, Sandra E. Smith
openalex   +1 more source

Piezo1 channels enhance anabolic signaling activation induced by electrical stimulation of cultured myotubes

FEBS Open Bio, EarlyView.
By using an electrical pulse stimulation (EPS)‐based in vitro exercise model and chemical activation/inhibition of mechanosensitive Piezo1 channels, we explored changes in protein synthetic response in cultured C2C12 myotubes. Our data showed that application of Piezo1 activator (Yoda1) during EPS significantly enhances the rate of protein synthesis in
Natalia A. Vilchinskaya, Ksenia V. Sergeeva, Boris S. Shenkman, Timur M. Mirzoev   +3 more
wiley   +1 more source

Mode of Action of Penicillin [PDF]

, 1945
G. LAPAGE
openalex   +1 more source

Positive feedback loop between MAPK and aquaporin 7 regulates autophagy and apoptosis induced by palmitate in RIN‐m5f cells

FEBS Open Bio, EarlyView.
T2DM is characterized by peripheral blood insulin resistance and progressive pancreatic β‐cell dysfunction. Here, we showed that AQP7, the only aquaglyceroporin protein, regulates autophagy and apoptosis in pancreatic β‐cells. We propose the existence of a positive feedback loop between MAPK signaling and AQP7 that regulates autophagy and apoptosis in ...
Maoqi Wang, Jiang Tan, Xueting He, Yuqin Chen, Guoping Qiu, Mei Yang   +5 more
wiley   +1 more source

VV-ECMO adjuvant therapy for Leptospira complicated with H1N1 infection: a case report

Frontiers in Medicine
BackgroundLeptospirosis is an acute infectious disease that occurs by infection, progresses rapidly, and has a high mortality rate, with an estimated 1.2 million new cases and nearly 59,000 deaths each year.
YuChou Zhang, MingJing Yin, HanChun Wen
doaj   +1 more source

Establishment and biological characterization of radioresistant colorectal cancer cell lines

FEBS Open Bio, EarlyView.
Under ionizing radiation exposure, radiation‐sensitive cancer cells exhibit oxidative stress and DNA damage, while radiation‐resistant cancer cells exhibit strong antioxidant properties and DNA damage repair. Radiotherapy resistance is a major cause of recurrence and metastasis in colorectal cancer (CRC).
Tian‐Yin Qu, Qing Dai, Jing Leng, Lin Fang, Jing‐Jing Ma, Rui Chen, Che Chen, Peng‐Fei Ran, Wen‐Wen Zhou, Chang Liu, Huang‐Fei Yu   +10 more
wiley   +1 more source