Results 141 to 150 of about 1,197,885 (388)

Raphin‐1 mediates the survival and sensitivity to radiation of pediatric‐type diffuse high‐grade glioma via phosphorylated eukaryotic initiation factor 2α‐dependent and ‐independent processes

Molecular Oncology, EarlyView.
Raphin‐1 reduces the survival of PED‐DHGG cells and enhances their radiation sensitivity through both PeIF2α‐dependent and PeIF2α‐independent mechanisms. Raphin‐1 sustains elevated levels of PeIF2α, contributing to its PeIF2α‐dependent effects. Additionally, raphin‐1 interacts with CReP to mediate a separate radiosensitizing pathway that operates ...
Karin Eytan, Moshe Leitner, Amos Toren, Shoshana Paglin, Michal Yalon   +4 more
wiley   +1 more source

Penicillin in the Treatment of Neonatal Sepsis [PDF]

, 1946
F. M. B. Allen, J. E. Morison, W. R. Rutherford   +2 more
openalex   +1 more source

Targeting carbonic anhydrase IX/XII prevents the anti‐ferroptotic effect of stromal lactic acid in prostate carcinoma

Molecular Oncology, EarlyView.
In prostate carcinoma, lactic acid, secreted by highly glycolytic cancer‐associated fibroblasts, is imported into tumor cells through the MCT1 transporter and prevents RSL3 and erastin‐induced ferroptosis (A). Targeting of carbonic anhydrase IX/XII, the main extracellular pH regulators, in tumor and stromal cells reduces microenvironmental acidosis and
Elisa Pardella, Giuseppina Comito, Luigi Ippolito, Erica Pranzini, Marta Iozzo, Giulia Gangarossa, Francesca Virgilio, Silvia Bua, Alessio Nocentini, Giada Sandrini, Nicla Lorito, Marina Bacci, Gabriella Nesi, Pietro Spatafora, Sergio Serni, Claudiu T. Supuran, Andrea Morandi, Paola Chiarugi, Elisa Giannoni   +18 more
wiley   +1 more source

THE RECOVERY OF BACTERIA FROM THE TOXIC EFFECTS OF PENICILLIN 1 [PDF]

, 1949
Harry Eagle
openalex   +1 more source

Matrigel inhibits elongation and drives endoderm differentiation in aggregates of mouse embryonic stem cells

FEBS Open Bio, EarlyView.
Stem cell‐based embryo models (SCBEMs) are valuable to study early developmental milestones. Matrigel, a basement membrane matrix, is a critical substrate used in various SCBEM protocols, but its role in driving stem cell lineage commitment is not clearly defined.
Atoosa Amel, Rachel Brown, Alexa Rabeling, Mubeen Goolam   +3 more
wiley   +1 more source

The role of major and minor determinants in penicillin allergy testing: Time to revisit an old friend?

Journal of Allergy and Clinical Immunology: Global, 2023
Background: Skin testing is an important step in evaluation of penicillin allergic reactions. It includes testing to the following: amoxicillin, benzyl penicillin, and products generated in vivo after penicillin administration, the major determinant ...
Syed B. Ali, MBBS, FRACP, Thanh-Thao Adriana Le, MBBS, FRACP, Aida Ahmadie, BNurs, Chino Yuson, MBBS, FRACP, Frank Kette, MBBS, FRACP, Pravin Hissaria, MD, FRACP, FRCPA, William B. Smith, MBBS, FRACP, FRCPA, PhD   +6 more
doaj  

ANTIGENIC AND ENZYME SYSTEM CHANGES IN BETA HEMOLYTIC STREPTOCOCCI RESISTANT TO PENICILLIN, STREPTOMYCIN, BACITRACIN AND AUREOMYCIN 1234 [PDF]

, 1949
Horace M. Gezon, Dorcas M. Fasan
openalex   +1 more source

Increased bile resistance in Salmonella enterica mutants lacking Prc periplasmic protease [PDF]

, 2013
Prc is a periplasmic protease involved in processing of penicillin-binding protein 3 (PBP3). Lack of Prc suppressesbile sensitivity in Dam-, Wec-, PhoP-, DamX-, and SeqA- mutants of Salmonella enterica, and increases bile resistance in thewild type ...
Francisco García-del Portillo, Gadea Rico-Pérez, Josep Casadesús, Juan A. Ayala, Sara B. Hernández   +4 more
core   +1 more source

Neurotoxic amyloid β‐peptide and tau produce cytokine‐like effects on PMCA in glioblastoma cell lines, enhancing its activity and isoforms expression

FEBS Open Bio, EarlyView.
Two biomarkers of Alzheimer's disease, amyloid β‐peptide (Aβ) and tau, induce the transformation of U‐251 and other glioblastoma cell lines into neurotoxic A1‐like reactive astrocytes. This transformation is produced by cytokines and is followed by upregulation of PMCA activity and isoform expression, and is closely associated with inflammation, as ...
María Berrocal, Alberto Alvarez‐Barrientos, Ana M. Mata   +2 more
wiley   +1 more source

Congenital syphilis neonatal alterations in a university hospital in Niterói - RJ

DST, 2013
Introduction: Syphilis is a sexually transmitted disease caused due to bacterium Treponema pallidum. The prevalence of this infection decreased significantly by the use of penicillin, but it is observed that it reappears particularly in cases of ...
Philippe Godefroy C de Souza, Antônio Rodrigues Braga Neto, Isabel Chulvis do Val, Dennis de Carvalho Ferreira, Carolina Rocha Galvão, Helena Lucia Barroso dos Reis   +5 more
doaj