Results 171 to 180 of about 384,367 (304)

Multidrug-resistant Staphylococcus cohnii and Staphylococcus urealyticus isolates from German dairy farms exhibit resistance to beta-lactam antibiotics and divergent penicillin-binding proteins. [PDF]

Sci Rep, 2021
Lienen T, Schnitt A, Hammerl JA, Marino SF, Maurischat S, Tenhagen BA.   +5 more
europepmc   +1 more source

Mutations in penicillin-binding protein 2 from cephalosporin-resistant Neisseria gonorrhoeae hinder ceftriaxone acylation by restricting protein dynamics [PDF]

, 2020
Avinash Singh, Jonathan M. Turner, Joshua Tomberg, Alena Fedarovich, Magnus Unemo, Robert A. Nicholas, Christopher Davies   +6 more
openalex   +1 more source

Bimetallic Nanoreactor Activates cGAS‐STING Pathway via mtDNA Release for Cancer Metalloimmunotherapy

Advanced Functional Materials, EarlyView.
A bimetallic Mn–Ca nanoreactor (MCC) is developed as a non‐nucleotide STING nanoagonist for cancer metalloimmunotherapy. MCC induces Ca2+ overload and hydroxyl radical generation, resulting in mitochondrial damage and mtDNA release. The released mtDNA cooperates with Mn2+ to robustly activate cGAS–STING signaling.
Xin Wang Mo, Nguyen Thi Nguyen, LiLi Guo, Ngoc Man Phan, Hyunsu Shin, Tae‐il Kim, Yu Seok Youn, Jaeyun Kim   +7 more
wiley   +1 more source

Weaknesses out of strength: PNA against the penicillin-binding proteins

Molecular Therapy: Nucleic Acids
Mateusz Wdowiak
doaj   +1 more source

Localization and Single Molecule Dynamics of <i>Bacillus subtilis</i> Penicillin-Binding Proteins Depend on Substrate Availability and Are Affected by Stress Conditions. [PDF]

Cells
Stuckenschneider L, Graumann PL.
europepmc   +1 more source

The role of the L421P mutation in Penicillin-Binding Protein 1 (PBP1) in the evolution of chromosomally mediated penicillin resistance in Neisseria gonorrhoeae [PDF]

Gabriella L. Gentile, Bryan B. Guzmán, Adriana Le Van, Ann E. Jerse, Yonatan H. Grad, Daniel Domínguez, Tatum D. Mortimer, Robert A. Nicholas   +7 more
openalex   +1 more source

Bioinspired Bromination Enables Extensible, Strain‐Stiffening Resilin Peptide Scaffolds with Tunable Degradation

Advanced Functional Materials, EarlyView.
Bioinspired bromination of a resilin‐derived peptide enables the fabrication of electrospun nanofibrous scaffolds that uniquely combine strain‐stiffening elasticity, proteolytic stability, and antioxidant functionality. These brominated peptide–gelatin hybrids mimic the extensibility of natural elastomers, demonstrating tunable mechanical resilience ...
Elisa Marelli, Lorenzo Sori, Chiara Russo, Claudia Pigliacelli, Lorenza Draghi, Monica Soncini, Pierangelo Metrangolo   +6 more
wiley   +1 more source

In vivo functional and molecular characterization of the Penicillin-Binding Protein 4 (DacB) of Pseudomonas aeruginosa [PDF]

, 2016
Cristian Gustavo Aguilera Rossi, Paulino Gómez‐Puertas, Juan A. Ayala   +2 more
openalex   +1 more source

Generating Cell Surface Nucleated Hydrogels with an Artificial Membrane‐Binding Transglutaminase

Advanced Functional Materials, EarlyView.
Cell‐based therapies require advanced strategies to enhance cell delivery and bioactivity. Cell membrane engineering offers an avenue to impart new functions to delivered cells to boost their viability and function. Here, an artificial membrane‐binding transglutaminase is generated and biophysically characterized.
Rosalia Cuahtecontzi Delint, Tao Li, Kapil D. Patel, Will H. Zhang, Ben M. Carter, Graham J. Day, Adam W. Perriman   +6 more
wiley   +1 more source

A microbiological and structural analysis of the interplay between sulbactam/durlobactam and imipenem against penicillin-binding proteins (PBPs) of <i>Acinetobacter</i> spp. [PDF]

Antimicrob Agents Chemother
Veeraraghavan B, Shin E, Bakthavatchalam YD, Manesh A, Dubey D, Tascini C, Taracila MA, Hujer AM, Jacobs MR, Bonomo RA.   +9 more
europepmc   +1 more source