Results 71 to 80 of about 36,910 (309)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Dephthaloylation of Phthalimido-Containing Cephalosporins and Penicillins [PDF]

, 1977
Dephthaloylation of phthalimido functionalized cephalosporins and penicillins via the corresponding phthalisoimides was performed.
S. Kukolja, S. R. Lammert, A. I. Ellis, Kukolja, S., Lammert, S. R., Ellis, A. I.   +5 more
core   +1 more source

Evaluation of different strategies to extract and preconcentrate penicillins present in milk prior determination by capillary electrophoresis.

Revista Científica, 2014
 One of the main problems concerning the determination of residues of penicillins (PENs) in complex matrix, as milk samples of animal origin, is the sample treatment. The aim of this work was to evaluate the influence of different background electrolyte
María Ysabel Piñero, Natividad Jurado, Roberto Bauza, Lourdes Arce, Miguel Valcárcel   +4 more
doaj  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Absence of cross-reactivity to carbapenems in patients with delayed hypersensitivity to penicillins [PDF]

, 2013
Studies performed on subjects with IgE-mediated hypersensitivity to penicillins have demonstrated a 1% rate of cross-reactivity between penicillins and both imipenem and meropenem, while a single study found a 5.5% rate of cross-reactivity with imipenem ...
Romano, Antonino
core   +1 more source

Perceived Knowledge and Confidence of Beta-Lactam Allergy Management Among Pharmacy Students on Advanced Pharmacy Practice Experiences

Pharmacy
Pharmacist engagement in allergy clarification has demonstrated increased appropriate antibiotic use. The purpose of this study was to determine the knowledge and confidence of pharmacy students in their final professional year regarding beta-lactam (BL)
Jamie L. Wagner, David R. Oliver, Bruce M. Jones, Kayla R. Stover, Misha T. Watts, Wesley D. Kufel, Lena McDowell, Edoabasi U. McGee, T. Lynn Stevenson, Christopher M. Bland   +9 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Effect of Phenylacetic Acid Addition on Productivity of Penicillium chrysogenum in Penicillin G Production Using Pilot Scale Reactor [PDF]

, 2012
Effect of penicillin’s precursor addition, phenylacetic acid (PAA), was done by addition of PAA in several concentrations in a pilot scale reactor batch culture to produce penicillin G with fungi Penicillium chrysogenum.
S, Suyanto,, Rofiq , Sunaryanto,, Amila , Pramisandi,, Erwahyuni, Endang Prabandari   +3 more
core  

Determination of natural penicillins in fermentation media by high-performance liquid chromatography using pre-column derivatisation with 1-hydroxybenzotriazole [PDF]

, 1988
The separation and determination of trace amounts of 6-aminopenicillanic acid (6-APAJ and penicillins G, V,X, K and penicillin G penicilloic acid in fermentation broths has been achieved using pre-columnderivatisation with 1 -hydroxybenzotriazole ...
Shah, A., Holt, G., Adlard, M.
core   +1 more source