Results 51 to 60 of about 36,910 (309)
Conformational studies of phynyl and isoxazolyl penicillins [PDF]
, 1982 Conformational energy calculations have been carried out on a few representative b-lactamase resistant and susceptible, phenyl and isoxazolyl penicillins.
Rao, VSR, Vasudevan, TK
core
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Clinical pharmacokinetics of penicillins in the neonate: a review of the literature [PDF]
, 2009 Sepsis is common in neonates and a major cause of morbidity and mortality. Sixty percent of preterm neonates receive at least one antibiotic during the first week of life, with penicillins being the most frequently administered antibiotics. The clearance
PACIFICI, GIAN MARIA +3 more
core +1 more source
A Review Of Drug Allergies: Diagnosis and Management
European Medical Journal Allergy & Immunology, 2016 Drug allergy, in clinical practice, includes a wide spectrum of immunologically-mediated hypersensitivity reactions, also called drug hypersensitivity reactions (DHRs).
Arvind Bamanikar
doaj
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
ANTIBACTERIAL THERAPY OF INFECTIVE ENDOCARDITIS
Alʹmanah Kliničeskoj Mediciny, 2016 The article analyzes the influence of infective endocarditis etiology on the clinical course of the disease. The role of Staphylococci as common pathogens is emphasized. Streptococci have faded in importance, though, streptococcal endocarditis is still a
M. A. Gurevich, N. A. Kuz’menko
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Tolerability of aztreonam and carbapenems in patients with IgE-mediated hypersensitivity to penicillins [PDF]
, 2014 Studies performed on samples larger than 100 subjects with a documented IgE-mediated hypersensitivity to penicillins have demonstrated a cross-reactivity rate of approximately 1% between penicillins and both imipenem and meropenem, whereas a single study
Romano, Antonino
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
, 2008 This chapter outlines selected recent developments, together with some reminders of traditional methods, in the chemistry of penams A (4-thia-1-azabicyclo[3.2.0]heptan-7-one) and penems B (4-thia-1-azabicyclo[3.2.0]hept-2-en-7-one).
Brulé, Cédric +1 more
core