Results 191 to 200 of about 17,826 (255)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, Volume 20, Issue 7, Page 1800-1813, July 2026.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Risk of invasive penile cancer after treatment of penile intraepithelial neoplasia. [PDF]

BJU Int
Bjartmar I, Gerdtsson A, Torbrand C, Kristiansen S.   +3 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, Volume 20, Issue 7, Page 1726-1741, July 2026.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Epidemiology of Eccrine Porocarcinoma in the United States: A Study of 948 Cases

International Journal of Dermatology, Volume 65, Issue 8, Page 1704-1706, August 2026.
Tejas P. Joshi, Sarah E. Rashdan, Michael R. Migden   +2 more
wiley   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, Volume 16, Issue 7, Page 1400-1413, July 2026.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Empowering people affected by penile cancer: towards a model for supportive self-management. [PDF]

Int J Impot Res
Paterson C, Earle W, Homewood D, Chee J, Yao H, Sengupta S, Agbejule OA, Knowles R, Ee C, Niyonsenga T, Davis ID.   +10 more
europepmc   +1 more source

Computer vision mechanical QA: Development, characterization, and five years of clinical performance

Journal of Applied Clinical Medical Physics, Volume 27, Issue 7, July 2026.
Abstract Background Quality assurance (QA) in radiation therapy is a critical component of ensuring accurate and consistent patient treatments, but many tasks are time consuming and rely on human visual acuity, which limits their accuracy. Purpose We aimed to automate monthly mechanical QA tests, improve measurement accuracy and precision, and decrease
Rachel B. Ger, Michael D. Armstrong, Daniel G. Robertson   +2 more
wiley   +1 more source

Comparing the Perioperative and Oncological Outcomes of Open Versus Minimally Invasive Inguinal Lymphadenectomy in Penile Cancer: A Systematic Review and Meta-Analysis. [PDF]

Cancers (Basel)
Tan YG, Fong KY, Goh NK, Lee AY, Tay KJ, Yuen JS, Abern MR, Chen K.   +7 more
europepmc   +1 more source

Ultrasensitive Detection of Porcine Epidemic Diarrhea Virus Infections Using Multivalent DNA Nanostructure‐Enabled Lateral Flow Assay

Advanced Healthcare Materials, Volume 15, Issue 26, 10 July 2026.
A multivalent DNA nanostructure‐enabled lateral flow assay was developed for rapid, ultrasensitive detection of porcine epidemic diarrhea virus (PEDV) nucleocapsid protein. Designer net‐shaped DNA nanostructures (DNA‐Net) presenting PEDV‐specific aptamers achieved ~1000‐fold enhanced binding, enabling detection of viral copies with Ct ≤ 37.42 within 10
Saurabh Umrao, Akhila Naru, Dhanush Gandavadi, Mengxi Zheng, Saraswathi Lanka, Hyeongjun Cho, Chau Nguyen Minh Hoang, Jianqiang Zhang, Ying Fang, Xing Wang   +9 more
wiley   +1 more source

Penile Cancer Profile in a Central European Context: Clinical Characteristics, Prognosis, and Outcomes-Insights from a Polish Tertiary Medical Center. [PDF]

Cancers (Basel)
Czajkowski M, Falis M, Błaczkowska A, Rybarczyk A, Wierzbicki PM, Gondek J, Matuszewski M, Hakenberg OW.   +7 more
europepmc   +1 more source