Results 171 to 180 of about 17,826 (255)

A Physiologically Based Pharmacokinetic Model to Predict Potential Drug–Drug Interactions of TPN171, a Novel Phosphodiesterase Type 5 Inhibitor

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 8, August 2026.
ABSTRACT TPN171 is a potent phosphodiesterase type 5 inhibitor used to treat pulmonary arterial hypertension and erectile dysfunction, primarily metabolized by CYP3A4. This study aimed to evaluate its drug–drug interaction (DDI) potential and determine the optimal dosing when co‐administered with CYP3A4 modulators.
Guanghui Tian, Tao Chen, Lei Li, Zhiqiang Wang, Hao Yang, Jiaxiang Juan, Yuanqin Duan, Jianghong Pei, Jingying Jia   +8 more
wiley   +1 more source

Comparison of efficacy and prognosis between neoadjuvant chemotherapy and adjuvant chemotherapy in penile cancer patients with regional lymph node metastasis. [PDF]

Front Oncol
You R, Ji Y, Yang X, Zhao Q, Cao Y, Ma J, Yu Z, Cui Y, Ma J, Li R, Miao L, Yang Y, Du P, Wang S.   +13 more
europepmc   +1 more source

Deep Understanding of Vaginal Microbiota in HPV‐Related Diseases From a Multi‐Omics Perspective

VIEW Medicine, Volume 1, Issue 1, August 2026.
Current understanding of the vaginal microbiota and roles of critical vaginal bacteria, including Lactobacillus and anaerobic pathogens, in human papillomavirus (HPV) infection and HPV‐related diseases from a multi‐omics perspective. ABSTRACT There is a large number of microorganisms in the human body, which are inseparable from human health.
Jianxujie Zheng, Qing Cong, Ling Lin, Liang Qiao   +3 more
wiley   +1 more source

Penile cancer: a rare clinical image. [PDF]

Pan Afr Med J
Jawade S, Wankhede P.
europepmc   +1 more source

Prognostic Factors for Postoperative Complications. An Aggregate Protocol for 10 Observational Studies From the Danish TRIPLE‐A Cohort of 1.2 Million Surgeries

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 7, August 2026.
ABSTRACT Background Postoperative complications substantially increase morbidity, mortality and healthcare costs. Understanding prognostic factors is essential for risk stratification, targeted prevention strategies, and development of prediction models.
Anders Peder Højer Karlsen, Asta Prescott, Caroline Folkersen, Jens Laigaard, Atena Saito, Caroline Lando Klammer, Mik Wetterslev, Emil Ipsen Ørskov, Mathilde Fahrendorff, Rebecca Kiær, Helene Holm Laigaard, Nichlas Hovmand, Lars Hyldborg Lundstrøm, Sebastian Buhl Rasmussen, Anders Kehlet Nørskov, Markus Harboe Olsen   +15 more
wiley   +1 more source

Endothelium‐ and epithelium‐derived novel endogenous catecholamines as modulators of the autonomic nervous system

British Journal of Pharmacology, Volume 183, Issue 15, Page 4091-4110, August 2026.
Abstract Catecholamines are classically viewed as neuronal transmitters and adrenal hormones; however, accumulating evidence demonstrates that sources other than nerve fibres and adrenal medulla play a fundamental role in local organ regulation. Physiological paradoxes, such as preserved organ function after denervation or transplantation, challenge a ...
Mariana G. de Oliveira, Edson Antunes, Fabiola Zakia Monica, Gilberto De Nucci   +3 more
wiley   +1 more source

Total Chemical Synthesis of Interleukin‐15 and Interleukin‐2: Taming Protein Hydrophobicity and Aggregation by a Versatile Solubilizing Strategy

Angewandte Chemie, Volume 138, Issue 30, 20 July 2026.
A reducible solubilizing tag strategy (RST‐2.0) enables the synthesis, purification and ligation of difficult peptides while being readily removable just during folding, which overcomes the common challenges from protein hydrophobicity and aggregation. With this method, we achieved the first total synthesis of native and N‐glycosylated IL‐15 as well as
Jingwen Zeng, Haiyan Zhou, Wang Xia, Hongxiang Wu, Xuechen Li   +4 more
wiley   +2 more sources

The clinical value of nanocarbon suspension and methylene blue in sentinel lymphatic tracing and pathologic fine sorting of penile cancer: a multicentre prospective study. [PDF]

Ann Med
Liu C, Tao T, Yang M, Pei F, Yan M, Sun L, Li D, Han J, Liu Q, Wan H, Liu W, Li S, Weng T, Li X, Pei B, Wang Y, Bai X, Wu G, Sang C, Ye N, Su Y, Xu P, Li G.   +22 more
europepmc   +1 more source

Etymology and entomology: The semiotics and ethics of multispecies gene nomenclatures

Journal of Linguistic Anthropology, Volume 36, Issue 2, August 2026.
Abstract This article examines controversies surrounding gene names that are perceived as humorous in the context of fruit flies but are considered rude in the clinical context of human medicine. Drawing on ethnographic fieldwork in insect laboratories, interviews with entomologists and geneticists, and an analysis of scientific and clinical ...
Colin M. E. Halverson
wiley   +1 more source

Temporal Trends and Differences in Inpatient Palliative Care Use in Metastatic Penile Cancer Patients. [PDF]

Biomedicines
Siech C, Scheipner L, Baudo A, de Angelis M, Jannello LMI, Di Bello F, Saad F, Shariat SF, Longo N, Carmignani L, de Cobelli O, Ahyai S, Briganti A, Banek S, Kluth LA, Chun FKH, Karakiewicz PI.   +16 more
europepmc   +1 more source