Results 91 to 100 of about 52,516 (291)

Multicargo Porous Cochlear Electrode Coating for Antifibrosis After Cochlear Implantation

Advanced Science, EarlyView.
This study presents a novel porous drug‐loading coating for cochlear electrodes, utilizing MA‐PDMS infused with GelMA hydrogel containing dexamethasone and MXene nanoparticles. The coating enhances biocompatibility, enables sustained drug release, reduces fibrosis, and preserves residual hearing post‐CI.
Lei Ren, Yangnan Hu, Xiaoqiong Ding, Menghui Liao, Tian Shen, Sixing Cao, Hui Zhang, Hong Cheng, Yanru Qi, Pan Feng, Xinyi Pang, Ling Lu, Huan Wang, Wenwen Liu, Renjie Chai, Lin Cheng   +15 more
wiley   +1 more source

KLF1 Promotes Cardiomyocyte Proliferation and Heart Regeneration Through Regulation of Wnt/β‐Catenin Signaling Pathway

Advanced Science, EarlyView.
In KLF1‐on (neonatal and Klf1 overexpression hearts) models, KLF1 regulates Wnt/β‐catenin signaling pathway and the expression of cell proliferation‐related genes via transcriptional and epigenetic mechanisms, which induces cardiomyocyte proliferation and cardiac regeneration in mice after myocardial infarction.
Yanglin Hao, Xi Zhang, Shuan Ran, Yuan Li, Weicong Ye, Song Wang, Xiaohan Li, Zilong Luo, Jiulu Zhao, Junjie Zong, Kexiao Zheng, Ran Li, Han Zhang, Longyong Lai, Pinyan Huang, Zifeng Zou, Wang Zhan, Zhang Yue, Jie Wu, Jiahong Xia   +19 more
wiley   +1 more source

Characteristics of enzymatic induction provoked by chlordane [PDF]

The effects of various stresses, such as restraint and lowering or raising of environmental temperature, in mice pretreated with chlordane were investigated.
Denys, A., Guilbert-Ber, E., Levy, J.
core   +1 more source

In vitro identification and in silico utilization of interspecies sequence similarities using GeneChip(® )technology [PDF]

, 2005
BACKGROUND: Genomic approaches in large animal models (canine, ovine etc) are challenging due to insufficient genomic information for these species and the lack of availability of corresponding microarray platforms. To address this problem, we speculated
Garcia, Joe GN, Grigoryev, Dmitry N, Irizarry, Rafael A, Ma, Shwu-Fan, Simon, Brett A, Ye, Shui Q   +5 more
core   +3 more sources

Potential of Pandanus odoratissimus as a CNS depressant in Swiss albino mice

Brazilian Journal of Pharmaceutical Sciences, 2011
In this study, several neuropharmacological effects of methanolic leaf extract of Pandanus odoratissimus (PO) (family; Pandanaceae) were studied in albino mice using various experimental models.
Sama Raju, Narra Venkata Subbaiah, Kandukuri Sreeramulu Reddy, Amit Das, Krishnan Bala Murugan   +4 more
doaj   +1 more source

Listerin Alleviates Alzheimer's Disease through IRE1‐mediated Decay of TLR4 mRNA

Advanced Science, EarlyView.
Alzheimer's disease (AD) progression is influenced by microglia‐mediated neuroinflammation. Here, it is demonstrated that Listerin suppresses neuroinflammatory signaling and cognitive impairment in AD models by triggering IRE1α‐mediated TLR4 mRNA decay. Adenoviral Listerin delivery reduces amyloid‐β pathology, positioning it as a new therapeutic target.
Fei Qin, Runyu Cao, Xuemei Bai, Jiahua Yuan, Wanwei Sun, Yi Zheng, Xiaopeng Qi, Wei Zhao, Bingyu Liu, Chengjiang Gao   +9 more
wiley   +1 more source

Yokukansan Enhances Pentobarbital-Induced Sleep in Socially Isolated Mice: Possible Involvement of GABAA – Benzodiazepine Receptor Complex

Journal of Pharmacological Sciences, 2011
.: In the present study, we investigated the effect of the Kampo medicine Yokukansan (YKS) on pentobarbital-induced sleep in group-housed and socially isolated mice. Socially isolated mice showed shorter sleeping time than the group-housed mice. YKS (300
Nobuaki Egashira, Ai Nogami, Katsunori Iwasaki, Ayumi Ishibashi, Naoki Uchida, Kotaro Takasaki, Kenichi Mishima, Ryoji Nishimura, Ryozo Oishi, Michihiro Fujiwara   +9 more
doaj  

MeCP2 Lactylation Protects against Ischemic Brain Injury by Transcriptionally Regulating Neuronal Apoptosis

Advanced Science, EarlyView.
MeCP2 lactylation protects against ischemic stroke by reducing brain infarct volume and improving neurological outcomes. Lactylation at K210/K249 exerts neuroprotective effects by repressing the transcription of apoptosis‐associated genes, including Pdcd4 and Pla2g6. HDAC3 and p300 serve as key regulatory enzymes for MeCP2 lactylation following stroke.
Min Sun, Yuxin Zhang, Rui Mao, Yan Chen, Pinyi Liu, Lei Ye, Siyi Xu, Junqiu Jia, Shu Shu, Huiya Li, Yanping Yin, Shengnan Xia, Yanting Chen, Yun Xu   +13 more
wiley   +1 more source

Changes in pentobarbital induced sleeping-time in mice infected with Schistosoma mansoni and immunosuppressed Alterações no tempo de anestesia pelo pentobarbital sódico em camundongos infectados pelo Schistosoma mansoni e imunossuprimidos

Revista do Instituto de Medicina Tropical de São Paulo, 1995
To evaluate whether the intensity of the hepatic granulomatous response induced by S. mansoni eggs plays a role in drug metabolism, mice were infected with 40 cercariae and tested to assess the sodic pentobarbital induced sleeping-time.
Sônia Maria de Assis Fonseca Tonelli, Geraldo Brasileiro Filho, Eugênio Marcos de Andrade Goulart, Paulo Marcos Zech Coelho   +3 more
doaj   +1 more source

Duration of Action of Pentobarbital as Influenced by Ether Anesthesia in Rats [PDF]

, 1957
Nicholas M. Greene, David J. Whittaker
openalex   +1 more source