Results 91 to 100 of about 165,661 (337)

Sensitivity to interaural time differences in the medial superior olive of a small mammal, the Mexican free-tailed bat [PDF]

, 1998
Neurons in the medial superior olive (MSO) are thought to encode interaural time differences (ITDs), the main binaural cues used for localizing low-frequency sounds in the horizontal plane. The underlying mechanism is supposed to rely on a coincidence of
Grothe, Benedikt, Park, Thomas J.
core   +1 more source

Prefrontal FGF1 Signaling is Required for Accumbal Deep Brain Stimulation Treatment of Addiction

Advanced Science, EarlyView.
This research delineates that a cortical‐accumbal pathway and local FGF1 signaling in the medial prefrontal cortex are critical for NAc‐DBS to be effective in altering morphine CPP. These findings demonstrate a top‐down motif to regulate the therapeutic effects of subcortical DBS on addiction and support the potential for addiction treatments involving
Wan‐Kun Gong, Xue Li, Le Wang, Qian Yang, Alix Tiran‐Cappello, Zhichao Liang, James Samsom, Quanying Liu, He Lin, Christelle Baunez, Fang Liu, Ti‐Fei Yuan   +11 more
wiley   +1 more source

Antinociceptive Effects of Intrathecal Landiolol Injection in a Rat Formalin Pain Model [PDF]

, 2012
Perioperative beta-blocker administration has recently been recommended for patients undergoing cardiac or other surgery due to the beneficial cardiovascular effects of these agents.
Itano, Yoshitaro, Kaku, Ryuji, Kanzaki, Hirotaka, Matsuoka, Yoshikazu, Mizobuchi, Satoshi, Morita, Kiyoshi, Nishie, Hiroyuki, Obata, Norihiko, Ouchida, Mamoru, Taniguchi, Arata, Tomotsuka, Naoto   +10 more
core   +1 more source

KLF1 Promotes Cardiomyocyte Proliferation and Heart Regeneration Through Regulation of Wnt/β‐Catenin Signaling Pathway

Advanced Science, EarlyView.
In KLF1‐on (neonatal and Klf1 overexpression hearts) models, KLF1 regulates Wnt/β‐catenin signaling pathway and the expression of cell proliferation‐related genes via transcriptional and epigenetic mechanisms, which induces cardiomyocyte proliferation and cardiac regeneration in mice after myocardial infarction.
Yanglin Hao, Xi Zhang, Shuan Ran, Yuan Li, Weicong Ye, Song Wang, Xiaohan Li, Zilong Luo, Jiulu Zhao, Junjie Zong, Kexiao Zheng, Ran Li, Han Zhang, Longyong Lai, Pinyan Huang, Zifeng Zou, Wang Zhan, Zhang Yue, Jie Wu, Jiahong Xia   +19 more
wiley   +1 more source

Retrospective harm benefit analysis of pre-clinical animal research for six treatment interventions [PDF]

, 2018
The harm benefit analysis (HBA) is the cornerstone of animal research regulation and is considered to be a key ethical safeguard for animals. The HBA involves weighing the anticipated benefits of animal research against its predicted harms to animals but
A Brønstad, BP Reines, C Holman, C Hooijmans, C Kilkenny, C Kilkenny, CA Richardson, Christine J. Nicol, CR Hooijmans, D Baker, D BJ Roberts, D Cohen, D Cressey, D DeGrazia, D Mellor, DG Contopoulos-Ioannidis, DG Hackam, DG Porter, ES Sena, F Stafleu, FP Gruber, G Griffin, GF Davies, H Grimm, I Anna S Olsson, Ipsos Mori, J Grant, J Lenzer, J McGrath, JA Hirst, JH Comroe Jr, JP Ioannidis, K Ker, K Laber, KK Tsilidis, L Carbone, L Vogt, M Macleod, M Ritskes-Hoitinga, MI Martić-Kehl, MR Macleod, N Brown, N Hawkes, N Percie du Sert, N Pollock, NA Andrews, NH Franco, NH Franco, P Alderson, P Bateson, P Bateson, P Perel, P Pound, P Pound, PA Sandercock, Pandora Pound, R Greek, S Wooding, SA Rands, SG Brown, T de Cock Buning, TS Reichlin, VC Henderson, VC Henderson   +63 more
core   +3 more sources

ADAR1‐HNRNPL‐Mediated CircCANX Decline Promotes Autophagy in Chronic Obstructive Pulmonary Disease

Advanced Science, EarlyView.
ADAR1‐HNRNPL interaction‐repressed circCANX recruits P53 mRNA and UPF1 to assemble a complex in nuclear. This complex promotes P53 mRNA degradation through the NMD pathway, and finally reduces autophagy and stress granules formation to further regulate inflammation.
Ting‐Ting Chen, Yuan‐Yuan Wei, Jia‐Ying Kang, Da‐Wei Zhang, Jing‐Jing Ye, Xi‐Shi Sun, Mei Hong, Wen‐Ting Zhang, Hui‐Mei Wu, Zhen‐Xing Ding, Guang‐He Fei   +10 more
wiley   +1 more source

Tetrandrine alleviates inflammation and neuron apoptosis in experimental traumatic brain injury by regulating the IRE1α/JNK/CHOP signal pathway

Brain and Behavior, Volume 12, Issue 12, December 2022., 2022
Abstract Aim The aim of this study was to investigate the therapeutic roles of Tetrandrine (TET) on traumatic brain injury (TBI) and the underlying mechanism. Method Traumatic injury model of hippocampal neurons and TBI mouse model were established to evaluate the therapeutic effects.
Huan Liu, Shiqing He, Chong Li, Jianpeng Wang, Qin Zou, Yongshi Liao, Rui Chen   +6 more
wiley   +1 more source

Yokukansan Enhances Pentobarbital-Induced Sleep in Socially Isolated Mice: Possible Involvement of GABAA – Benzodiazepine Receptor Complex

Journal of Pharmacological Sciences, 2011
.: In the present study, we investigated the effect of the Kampo medicine Yokukansan (YKS) on pentobarbital-induced sleep in group-housed and socially isolated mice. Socially isolated mice showed shorter sleeping time than the group-housed mice. YKS (300
Nobuaki Egashira, Ai Nogami, Katsunori Iwasaki, Ayumi Ishibashi, Naoki Uchida, Kotaro Takasaki, Kenichi Mishima, Ryoji Nishimura, Ryozo Oishi, Michihiro Fujiwara   +9 more
doaj  

Changes in pentobarbital induced sleeping-time in mice infected with Schistosoma mansoni and immunosuppressed Alterações no tempo de anestesia pelo pentobarbital sódico em camundongos infectados pelo Schistosoma mansoni e imunossuprimidos

Revista do Instituto de Medicina Tropical de São Paulo, 1995
To evaluate whether the intensity of the hepatic granulomatous response induced by S. mansoni eggs plays a role in drug metabolism, mice were infected with 40 cercariae and tested to assess the sodic pentobarbital induced sleeping-time.
Sônia Maria de Assis Fonseca Tonelli, Geraldo Brasileiro Filho, Eugênio Marcos de Andrade Goulart, Paulo Marcos Zech Coelho   +3 more
doaj   +1 more source

Physical Dependence on Pentobarbital [PDF]

, 1984
departmental bulletin ...
1000090130757, 1000090130757, 80, 90130757, スズキ, ツトム, 鈴木, 勉   +5 more
core   +1 more source