Results 131 to 140 of about 52,516 (291)

Pia Mater‐Penetrable Lipopolymer Nanoparticles for Gliocyte‐Targeted IL‐10 mRNA Therapy Alleviate Paclitaxel‐Induced Peripheral Neuropathy

open access: yesAdvanced Science, EarlyView.
The P6CIT lipopolymer demonstrates superior transfection efficacy in the spinal cord and DRG, as well as enhanced penetration of the pia mater compared to the MC3 ionizable lipid. Intrathecal delivery of P6CIT LPNPs enables effective transfection in the gliocytes in the spinal cord and DRG.
Xinrou Lin   +10 more
wiley   +1 more source

In vivo neurological assessment of sedative hypnotic effect of Coriandrum sativum L. seeds in mice. [PDF]

open access: yes, 2015
Ethnopharmacological relevance: seeds of Coriandrum sativum L. have been used in the traditional medicine to relieve stress and other neurological disease conditions.
Abdulrahman M Alshahrani
core   +1 more source

The effect of different immobilization approaches on red-eared sliders

open access: yesScientific Reports
The ethical issues surrounding sacrifice methods in animal experimentation have garnered increasing attention, making immobilization and sedation an integral part of the sacrifice process for experimental animals.
Xin Niu   +7 more
doaj   +1 more source

Potentiation of Pentobarbital Anesthesia by Competitive Protein Binding [PDF]

open access: bronze, 1963
Elliott C. Lasser   +2 more
openalex   +1 more source

3D‐Printed Titanium Trabecular Scaffolds with Sustained Release of Hypoxia‐Induced Exosomes for Dual‐Mimetic Bone Regeneration

open access: yesAdvanced Science, EarlyView.
This study presents 3D‐printed Ti‐6Al‐4V trabecular scaffolds combined with hypoxia‐induced exosomes encapsulated in PEGDA/GelMA microspheres for sustained release. The scaffolds mimic the structure of natural bone, while the exosome delivery system enhances osteogenesis and angiogenesis, significantly promoting bone regeneration and offering a ...
Lincong Luo   +14 more
wiley   +1 more source

An Intelligent and Conductive Hydrogel with Multiresponsive and ROS Scavenging Properties for Infection Prevention and Anti‐Inflammatory Treatment Assisted by Electrical Stimulation for Diabetic Wound

open access: yesAdvanced Science, EarlyView.
This study introduces a novel therapeutic approach that employs a conductive hydrogel (HEPP) responsive to near‐infrared light, pH levels, and reactive oxygen species. Its goal is to enhance the healing environment affected by elevated glucose levels, insufficient oxygen, and bacterial infections in diabetes‐related wounds.
Tao Zhang   +4 more
wiley   +1 more source

Amniotic-Fluid Ingestion Enhances the Central\ud Analgesic Effect of Morphine [PDF]

open access: yes, 1991
Amniotic fluid and placenta contain a substance (POEF) that when ingested enhances opioid-mediated analgesia produced by several agents (morphine injection, vaginal/cervical stimulation, late pregnancy, footshock), but not that produced by aspirin ...
DiPirro, Jean M.   +2 more
core  

Investigations of the effects on the blood glucose levels of surgery and general anaesthesia with xylazine -ketamine and xylazine-pentobarbital sodium in healthy dogs [PDF]

open access: yesEurasian Journal of Veterinary Sciences
In this study, the effects of surgery and general anaesthesia that is with xylazine -ketamine hydrochloride and xylazine-pentobarbital sodium used commonly in carnivore, on the blood glucose levels, were investigated.
Celal İzci   +3 more
doaj  

Oxytocin‐Mediate Modulation of Splenic Immunosuppression in Chronic Social Stress Through Neuroendocrine Pathways

open access: yesAdvanced Science, EarlyView.
Chronic social stress elevates oxytocin levels, leading to immunosuppression by enhancing regulatory T‐cell activity and promoting anti‐inflammatory macrophage polarization in the spleen. Blocking oxytocin signaling reverses these effects but worsens stress‐induced behavioral disorders and reduces survival rates. This highlights oxytocin's dual role in
Yi‐Shu Zhang   +5 more
wiley   +1 more source

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