Results 11 to 20 of about 129,200 (329)

CircNOLC1 Promotes Colorectal Cancer Liver Metastasis by Interacting with AZGP1 and Sponging miR‐212‐5p to Regulate Reprogramming of the Oxidative Pentose Phosphate Pathway

Advanced Science, 2023
Liver metastasis is a common cause of death in progressive colorectal cancer patients, but the molecular mechanisms remain unclear. Here, it is reported that a conserved and oxidative pentose phosphate pathway‐associated circular RNA, circNOLC1, plays a ...
Menglang Yuan, Xinsheng Zhang, Fangxia Yue, Feifan Zhang, Sufen Jiang, Xu Zhou, Jinjuan Lv, Zhenyu Zhang, Yuzhu Sun, Zihao Chen, Han Wu, Xiaoqian Liu, Xiaoqi Yu, Bowen Wei, Kexin Jiang, Fang Lin, Yunfei Zuo, Shuangyi Ren   +17 more
doaj   +2 more sources

Pentose Phosphate Pathway Reactions in Photosynthesizing Cells

Cells, 2021
The pentose phosphate pathway (PPP) is divided into an oxidative branch that makes pentose phosphates and a non-oxidative branch that consumes pentose phosphates, though the non-oxidative branch is considered reversible.
Thomas D. Sharkey
doaj   +2 more sources

Engineering of Pentose Transport in Saccharomyces cerevisiae for Biotechnological Applications

Frontiers in Bioengineering and Biotechnology, 2020
Lignocellulosic biomass yields after hydrolysis, besides the hexose D-glucose, D-xylose, and L-arabinose as main pentose sugars. In second generation bioethanol production utilizing the yeast Saccharomyces cerevisiae, it is critical that all three sugars
Jeroen G. Nijland, Arnold J. M. Driessen
doaj   +2 more sources

Emerging role of the pentose phosphate pathway in hepatocellular carcinoma [PDF]

Frontiers in Oncology, 2017
In recent years, there has been a revival of interest in metabolic changes of cancer cells as it has been noticed that malignant transformation and metabolic reprogramming are closely intertwined.
Columbano, Amedeo, Kowalik, MARTA ANNA, Perra, Andrea   +2 more
core   +3 more sources

Glycolysis and the Pentose Phosphate Pathway Promote LPS-Induced NOX2 Oxidase- and IFN-β-Dependent Inflammation in Macrophages

Antioxidants, 2022
Macrophages undergo a metabolic switch from oxidative phosphorylation to glycolysis when exposed to gram-negative bacterial lipopolysaccharide (LPS), which modulates antibacterial host defence mechanisms.
Jonathan R. Erlich, Eunice E. To, Raymond Luong, Felicia Liong, Stella Liong, Osezua Oseghale, Mark A. Miles, Steven Bozinovski, Robert D. Brooks, Ross Vlahos, Stanley Chan, John J. O’Leary, Doug A. Brooks, Stavros Selemidis   +13 more
doaj   +2 more sources

Cannabidiol attenuates OGD/R-induced damage by enhancing mitochondrial bioenergetics and modulating glucose metabolism via pentose-phosphate pathway in hippocampal neurons

Redox Biology, 2017
Deficient bioenergetics and diminished redox conservation have been implicated in the development of cerebral ischemia/reperfusion injury. In this study, the mechanisms underlying the neuroprotective effects of cannabidiol (CBD), a nonpsychotropic ...
Shanshan Sun, Fangyuan Hu, Jihong Wu, Shenghai Zhang   +3 more
doaj   +2 more sources

The Pentose Phosphate Pathway in Yeasts–More Than a Poor Cousin of Glycolysis

Biomolecules, 2021
The pentose phosphate pathway (PPP) is a route that can work in parallel to glycolysis in glucose degradation in most living cells. It has a unidirectional oxidative part with glucose-6-phosphate dehydrogenase as a key enzyme generating NADPH, and a non ...
Laura-Katharina Bertels, Lucía Fernández Murillo, J. Heinisch   +2 more
semanticscholar   +1 more source

Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer

Nature Cell Biology, 2020
SLC7A11-mediated cystine uptake is critical for maintaining redox balance and cell survival. Here we show that this comes at a significant cost for cancer cells with high levels of SLC7A11.
Xiaoguang Liu, Kellen L. Olszewski, Yilei Zhang, Esther W. Lim, Jiejun Shi, Xiaoshan Zhang, Jie Zhang, Hyemin Lee, Pranavi Koppula, Guang Lei, L. Zhuang, M. J. You, B. Fang, Wei Li, Christian M. Metallo, M. Poyurovsky, B. Gan   +16 more
semanticscholar   +1 more source

The Pentose Phosphate Pathway in Cancer: Regulation and Therapeutic Opportunities

Chemotherapy, 2021
Background: Tumorigenesis is associated with deregulation of nutritional requirements, intermediary metabolites production, and microenvironment interactions.
Noor B Ghanem, Chirine El-Baba, Khaled Araji, R. El-Khoury, J. Usta, N. Darwiche   +5 more
semanticscholar   +1 more source

A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway

Nature Chemical Biology, 2020
Glucose is catabolized by two fundamental pathways, glycolysis to make ATP and the oxidative pentose phosphate pathway to make reduced nicotinamide adenine dinucleotide phosphate (NADPH).
J. Ghergurovich, J. García-Cañaveras, Joshua Z. Wang, E. Schmidt, Zhaoyue Zhang, T. TeSlaa, Harsh Patel, Li Chen, Emily C. Britt, Marta Piqueras-Nebot, M. Gómez-Cabrera, A. Lahoz, Jing Fan, U. Beier, Hahn Kim, Joshua D. Rabinowitz   +15 more
semanticscholar   +1 more source