Results 121 to 130 of about 22,602 (353)

Harnessing energy metabolism for enhanced bone defect repair: Mechanisms and therapeutic strategies

open access: yesVIEW, EarlyView.
This review addresses the critical challenge of bone defect repair by focusing on the underexplored role of cellular energy metabolism. It synthesizes regulatory mechanisms in bone‐forming cells and sums up innovative strategies—leveraging cell derivatives, active factors, and biomimetic scaffolds—to modulate metabolism for enhanced regeneration.
Junting Li   +5 more
wiley   +1 more source

A Química “Doce” do Vinho [PDF]

open access: yes, 2012
A QUÍMICA “DOCE” DO VINHO A definição enológica e legal designa o vinho como um produto natural obtido exclusivamente pela fermentação alcoólica, total ou parcial, de uvas frescas ou do mosto de uvas frescas.
Galacho, Cristina
core  

CRISPR/Cas9 Genome Engineering in Non‐Conventional Oleaginous Yeasts: Applications, Challenges, and Prospects

open access: yesYeast, EarlyView.
ABSTRACT Given the biotechnological potential of yeast‐derived oils for oleochemical production, genes encoding lipid metabolism enzymes are key targets for metabolic engineering. Genetic engineering tools such as Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9, Transcription Activator‐Like Effector Nucleases (TALENs), Zinc ...
Rodrigo Gonçalves Dias   +5 more
wiley   +1 more source

Sex-associated differences in baseline urinary metabolites of healthy adults. [PDF]

open access: yes, 2018
The biological basis for gender variability among disease states is not well established. There have been many prior efforts attempting to identify the unique urine metabolomic profiles associated with specific diseases.
Anger, Jennifer T   +6 more
core   +1 more source

Maltase 1 regulates DENV2 infection and life history in Aedes aegypti

open access: yesInsect Science, EarlyView.
Our study employed CRISPR/Cas9 to generate a MAL1 knockout strain of Aedes aegypti, demonstrating that the absence of MAL1 significantly suppresses DENV2 replication in the midgut and impairs viral transmission. The mutation also altered life‐history (hatching/pupation/emerging rates and sex‐specific survival), identifying MAL1 as a novel target for ...
Man‐Jin Li   +5 more
wiley   +1 more source

TcALS knockdown accelerates metamorphosis via insulin signaling in Tribolium castaneum

open access: yesInsect Science, EarlyView.
RNAi silencing of TcALS accelerates larva‐to‐pupa metamorphosis in Tribolium castaneum. Abstract Insect metamorphosis is an evolutionary adaptation precisely regulated by nutritional and hormonal cues. The red flour beetle Tribolium castaneum, a major stored‐product pest, serves as an excellent model for studying this process.
Min Li   +8 more
wiley   +1 more source

Cellulosic Ethanol Technology Assessment [PDF]

open access: yes
Resource /Energy Economics and Policy,
Bothast, Rodney J.
core   +1 more source

Levels of metabolites of glycolysis, the pentose phosphate pathway, tricarboxylic acid cycle and glyconeogenesis/glycogenolysis in cultured macrophages.

open access: green, 2015
Atsushi Yamashita   +13 more
openalex   +2 more sources

The pentose phosphate pathway constitutes a major metabolic hub in pathogenic Francisella

open access: gold, 2021
Héloïse Rytter   +14 more
openalex   +2 more sources

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