Results 51 to 60 of about 28,627 (213)

Computational, In Vitro, and In Vivo Evaluation of Benzimidazole–Pyrazole Hybrid Scaffolds as Multi‐Target Anti‐Ulcer Agents

open access: yesChemistry &Biodiversity, Volume 23, Issue 9, September 2026.
The hybrid pharmacophore approach involves the combination of benzimidazole‐pyrazole moieties to form multi‐functional anti‐ulcer compounds. Molecular modeling and biological evaluations show significant proton pump inhibition, anti‐inflammatory action, antioxidant property, and remarkable prevention of gastric ulcers.
Hafiz Aamir Ali Kharl   +8 more
wiley   +1 more source

Twin Studies on Urinary Pepsinogen A Phenotypes and Serum Pepsinogen A Levels

open access: yesActa geneticae medicae et gemellologiae: twin research, 1987
AbstractUrinary pepsinogen A (PGA or PG I) phenotypes and serum PGA levels were studied in MZ and DZ twins and their parents. In 45 out of 48 MZ twin pairs PGA patterns were completely identical, while 3 MZ twin pairs showed minor differences in the relative intensity of the Pg5 isozymogen.
Pronk, J.C.   +7 more
openaire   +4 more sources

Exocrine Gland Dysfunction in Parkinson's Disease: Pathophysiology, Clinical Manifestations, and Therapeutic Perspectives—A Narrative Review

open access: yesMovement Disorders Clinical Practice, Volume 13, Issue 9, Page 2081-2092, September 2026.
Abstract Background Non‐motor symptoms, especially autonomic dysfunction, are major contributors to disability and decreased quality of life in Parkinson's disease (PD). Despite being common and having a wide range of clinical facets, exocrine gland dysfunction is still not well recognized and managed.
Renato P. Munhoz   +2 more
wiley   +1 more source

Covalent structure of chicken pepsinogen [PDF]

open access: yesEuropean Journal of Biochemistry, 1983
Chicken pepsinogen is a glycoprotein consisting of a single polypeptide chain and containing the following 367 amino acid residues: Asp23, Asn16, Thr26, Ser41, Glu14, Gln11, Pro18, Gly31, Ala17, Cys7, Val25, Met9, Ile23, Leu28, Tyr22, Phe20, His8, Lys17, Arg7, Trp4. The Mr‐value of the protein is 42074.
M, Baudys, V, Kostka
openaire   +3 more sources

Pepsinogen I as a marker of risk of gastric mucosal cell destruction in Helicobacter pylori-infected patients taking acetylsalicylic acid

open access: yesGastroenterologìa
Background. Antiplatelet therapy is a major component of the treatment in patients at high risk of cardiovascular complications. Antiplatelet agents that are used to prevent blood clots can have several adverse effects on the gastrointestinal tract, such
I.G. Paliy   +3 more
doaj   +1 more source

Gastric Mucosal Molecular Alterations and Multimodal Field‐Based Risk Models for Gastric Cancer Development

open access: yesCancer Science, Volume 117, Issue 9, Page 2323-2334, September 2026.
DNA methylation in non‐neoplastic background gastric mucosa reflects cumulative inflammatory and exposure‐related field changes before cancer develops. Combining methylation with clinical, endoscopic, histological, and emerging multimodal information may refine calibrated gastric cancer risk prediction and support risk‐adapted personalized endoscopic ...
Genki Usui, Atsushi Kaneda
wiley   +1 more source

No association of coffee consumption with gastric ulcer, duodenal ulcer, reflux esophagitis, and non-erosive reflux disease: a cross-sectional study of 8,013 healthy subjects in Japan. [PDF]

open access: yesPLoS ONE, 2013
Probably due to caffeine-induced gastric acid secretion, negative effects of coffee upon various upper-gastrointestinal diseases have been precariously accepted, despite the inadequate epidemiological evidence. Our aim is to evaluate the effect of coffee
Takeshi Shimamoto   +7 more
doaj   +1 more source

The Level of Serum Pepsinogen in Diagnosing and Evaluating the Severity of Subacute Combined Degeneration Due to Vitamin B12 Deficiency

open access: yesFrontiers in Neurology, 2021
Subacute combined degeneration (SCD) is a neurological complication of cobalamin deficiency, which is usually caused by chronic autoimmune atrophic gastritis.
Xiaoyan Chen   +5 more
doaj   +1 more source

Beyond Helicobacter pylori: Prevalence, Coinfection, and Clinicopathologic Patterns of Non‐Helicobacter pylori Helicobacter (NHPH) in Human Gastric Biopsies

open access: yesHelicobacter, Volume 31, Issue 5, September/October 2026.
ABSTRACT Background Non‐Helicobacter pylori Helicobacter (NHPH) species are increasingly recognized as human gastric colonizers, yet their prevalence, species distribution, and clinical significance remain incompletely defined, particularly in patient cohorts in the Middle East.
Daniel Vizenblit   +5 more
wiley   +1 more source

The prevalence of atrophic gastritis of the body of stomach at Krasnoyarsk population over 45 years old

open access: yesРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии, 2012
Aim of investigation. To determine prevalence of atrophic gastritis of body of the stomach at Krasnoyarsk population over 45 years old.Material and methods.
V. V. Tsukanov   +7 more
doaj  

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