Results 41 to 50 of about 166,295 (311)

Mechanisms of HIV Protein Degradation into Epitopes: Implications for Vaccine Design

Viruses, 2014
The degradation of HIV-derived proteins into epitopes displayed by MHC-I or MHC-II are the first events leading to the priming of HIV-specific immune responses and to the recognition of infected cells.
Marijana Rucevic, Julie Boucau, Jens Dinter, Georgio Kourjian, Sylvie Le Gall   +4 more
doaj   +1 more source

Evolution and Role of Proteases in Campylobacter jejuni Lifestyle and Pathogenesis

Biomolecules, 2023
Infection with the main human food-borne pathogen Campylobacter jejuni causes campylobacteriosis that accounts for a substantial percentage of gastrointestinal infections. The disease usually manifests as diarrhea that lasts for up to two weeks.
Bodo Linz, Irshad Sharafutdinov, Nicole Tegtmeyer, Steffen Backert   +3 more
doaj   +1 more source

DataSheet_1_Dipeptidyl-Peptidase-IV Inhibitors, Imigliptin and Alogliptin, Improve Beta-Cell Function in Type 2 Diabetes.docx

, 2021
ObjectsImigliptin is a novel dipeptidyl peptidase-4 inhibitor. In the present study, we aimed to evaluate the effects of imigliptin and alogliptin on insulin resistance and beta-cell function in Chinese patients with type-2 diabetes mellitus (T2DM ...
Xinhua Xiao (486688), Jianhong Yang (3007035), Hongzhong Liu (1521580), Dongyang Liu (2891114), Pei Hu (1489597), Yang Liu (4829), Haiyan Li (168109), Xu Liu (276996)   +7 more
core   +1 more source

Genome Wide Mapping of Peptidases in Rhodnius prolixus: Identification of Protease Gene Duplications, Horizontally Transferred Proteases and Analysis of Peptidase A1 Structures, with Considerations on Their Role in the Evolution of Hematophagy in Triatominae

Frontiers in Physiology, 2017
Triatominae is a subfamily of the order Hemiptera whose species are able to feed in the vertebrate blood (i.e., hematophagy). This feeding behavior presents a great physiological challenge to insects, especially in Hemipteran species with a digestion ...
Bianca S. Henriques, Bruno Gomes, Samara G. da Costa, Caroline da Silva Moraes, Rafael D. Mesquita, Rafael D. Mesquita, Viv M. Dillon, Eloi de Souza Garcia, Eloi de Souza Garcia, Patricia Azambuja, Patricia Azambuja, Roderick J. Dillon, Fernando A. Genta, Fernando A. Genta   +13 more
doaj   +1 more source

Crystal structures of trypanosoma brucei oligopeptidase B broaden the paradigm of catalytic regulation in prolyl oligopeptidase family enzymes [PDF]

, 2013
Oligopeptidase B cleaves after basic amino acids in peptides up to 30 residues. As a virulence factor in bacteria and trypanosomatid pathogens that is absent in higher eukaryotes, this is a promising drug target.
Rory E Morty, Canning Peter, Rea, Dean, Dean Rea (483664), Morty Rory E., Morty, Rory E., Dean Rea, Vilmos Fülöp, Rory E. Morty (341515), Canning, Peter, Fülöp, Vilmos, Peter Canning, Peter Canning (483663), Vilmos Fülöp (483665), Rea Dean, Fülöp Vilmos   +15 more
core   +1 more source

Fusaoctaxin A, an Example of a Two-Step Mechanism for Non-Ribosomal Peptide Assembly and Maturation in Fungi

Toxins, 2019
Fungal non-ribosomal peptide synthetase (NRPS) clusters are spread across the chromosomes, where several modifying enzyme-encoding genes typically flank one NRPS.
Klaus Ringsborg Westphal, Katrine Amalie Hamborg Nielsen, Rasmus Dam Wollenberg, Mathias Bonde Møllehøj, Simone Bachleitner, Lena Studt, Erik Lysøe, Henriette Giese, Reinhard Wimmer, Jens Laurids Sørensen, Teis Esben Sondergaard   +10 more
doaj   +1 more source

Cellular functions of gamma-secretase-related proteins [PDF]

, 2006
Amyloid-beta pepticle (A beta) is generated by gamma-secretase, a membrane protein complex with an unusual aspartyl protease activity consisting of the four components presenilin, nicastrin, APH-1 and PEN-2. Presenilin is considered the catalytic subunit
Haffner, Christof, Haass, Christian
core   +1 more source

OPTIMIZATION OF PARAMETERS OF FERMENTOLYSIS OF PROTEINS IN THE COMPOSITION OF SERUM-PROTEIN CONCENTRATE

Harčova Nauka ì Tehnologìâ, 2018
The food industry is a strategic industry that works quite steadily even during periods of economic crises, providing food security to any state, and is a source of raw material for other industries with a high potential for development, for example, for
N. Tkachenko, L. Lanzhenko, D. Skripnichenko, N. Kuprina, А. Hanicheva   +4 more
doaj   +1 more source

A Multi-season Investigation of Microbial Extracellular Enzyme Activities in Two Temperate Coastal North Carolina Rivers: Evidence of Spatial but Not Seasonal Patterns

Frontiers in Microbiology, 2017
Riverine systems are important sites for the production, transport, and transformation of organic matter. Much of the organic matter processing is carried out by heterotrophic microbial communities, whose activities may be spatially and temporally ...
Avery Bullock, Kai Ziervogel, Sherif Ghobrial, Shannon Smith, Brent McKee, Carol Arnosti   +5 more
doaj   +1 more source

Molecular cloning and characterization of a novel peptidase from Trichinella spiralis and protective immunity elicited by the peptidase in BALB/c mice

Veterinary Research, 2020
In our previous studies, a novel T. spiralis peptidase (TsP) was identified among the excretory/secretory (ES) proteins of T. spiralis intestinal infective larvae (IIL) and T.
Jun Jun Lei, Yuan Yuan Hu, Fang Liu, Shu Wei Yan, Ruo Dan Liu, Shao Rong Long, Peng Jiang, Jing Cui, Zhong Quan Wang   +8 more
doaj   +1 more source