Results 51 to 60 of about 166,295 (311)

KLK7 (kallikrein-related peptidase 7) [PDF]

, 2010
Review on KLK7 (kallikrein-related peptidase 7), with data on DNA, on the protein encoded, and where the gene is ...
Clements, JA, Dong, Ying, Lai, J, Clements, Judith, Y Dong, JA Clements, J Lai, Dong, Y, Lai, John   +8 more
core   +1 more source

Signal peptide peptidases and gamma-secretase: Cousins of the same protease family? [PDF]

, 2007
Signal peptide peptidase (SPIP) is an unusual aspartyl protease, which mediates clearance of signal peptides by proteolysis within the endoplasmic reticulum (ER).
Fluhrer, Regina, Haass, Christian
core   +1 more source

Unravelling HetC as a peptidase-based ABC exporter driving functional cell differentiation in the cyanobacterium Nostoc PCC 7120

Microbiology Spectrum
The export of peptides or proteins is essential for a variety of important functions in bacteria. Among the diverse protein-translocation systems, peptidase-containing ABC transporters (PCAT) are involved in the maturation and export of quorum-sensing or
Raphaël Rachedi, Véronique Risoul, Maryline Foglino, Yanis Aoudache, Kevin Lang, Stéphanie Champ, Elise Kaplan, Cédric Orelle, Badreddine Douzi, Jean-Michel Jault, Amel Latifi   +10 more
doaj   +1 more source

Distributions of Extracellular Peptidases Across Prokaryotic Genomes Reflect Phylogeny and Habitat

Frontiers in Microbiology, 2019
Proteinaceous compounds are abundant forms of organic nitrogen in soil and aquatic ecosystems, and the rate of protein depolymerization, which is accomplished by a diverse range of microbial secreted peptidases, often limits nitrogen turnover in the ...
Trang T. H. Nguyen, David D. Myrold, Ryan S. Mueller   +2 more
doaj   +1 more source

Type IV prepilin peptidase

, 2004
International audienceThis chapter covers the structural chemistry and the biological aspects of type IV prepilin peptidase. Type IV prepilin peptidases and type IV prepilin-like peptidases are homologous over their entire amino acid sequences, and in ...
Deghmane, Ala-Eddine, Taha, Muhamed-Kheir, Ala-Eddine Deghmane, Muhamed-Kheir Taha, Dupuy, Bruno, Bruno Dupuy   +5 more
core   +1 more source

Influence of PepF peptidase and sporulation on microcin J25 production in Bacillus subtilis

Microbiology Spectrum
The lasso peptide microcin J25 (MccJ25) possesses strong antibacterial properties and is considered a potential effective component of bacterial disease treatment drugs and safe food preservatives.
Guangwen Zhang, Saixiang Feng, Miaomiao Qin, Juan Sun, Yutong Liu, Changqi Luo, Min Lin, Siqi Xu, Ming Liao, Huiying Fan, Zhaoping Liang   +10 more
doaj   +1 more source

Trelagliptin (SYR-472, Zafatek), Novel Once-Weekly Treatment for Type 2 Diabetes, Inhibits Dipeptidyl Peptidase-4 (DPP-4) via a Non-Covalent Mechanism. [PDF]

PLoS ONE, 2016
Trelagliptin (SYR-472), a novel dipeptidyl peptidase-4 inhibitor, shows sustained efficacy by once-weekly dosing in type 2 diabetes patients. In this study, we characterized in vitro properties of trelagliptin, which exhibited approximately 4- and 12 ...
Charles E Grimshaw, Andy Jennings, Ruhi Kamran, Hikaru Ueno, Nobuhiro Nishigaki, Takuo Kosaka, Akiyoshi Tani, Hiroki Sano, Yoshinobu Kinugawa, Emiko Koumura, Lihong Shi, Koji Takeuchi   +11 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

The MEROPS Database

, 2009
Many proteins undergo important post-translational proteolytic processing to remove targeting signals and activation peptides, and most proteins undergo proteolytic inactivation and catabolism.
Neil D. Rawlings, Alan J. Barrett
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source