Results 11 to 20 of about 1,752,184 (298)

Accurate control of dual-receptor-engineered T cell activity through a bifunctional anti-angiogenic peptide

open access: yesJournal of Hematology & Oncology, 2018
Background Chimeric antigen receptors (CARs) presented on T cell surfaces enable redirection of T cell specificity, which has enormous promise in antitumor therapy.
Erhao Zhang   +11 more
doaj   +1 more source

CD146 Associates with Gp130 to Control a Macrophage Pro‐inflammatory Program That Regulates the Metabolic Response to Obesity

open access: yesAdvanced Science, 2022
The mechanism of obesity‐related metabolic dysfunction involves the development of systemic inflammation, largely mediated by macrophages. Switching of M1‐like adipose tissue macrophages (ATMs) to M2‐like ATMs, a population of macrophages associated with
Hongxia Duan   +10 more
doaj   +1 more source

Label-free method for anti-glucopeptide antibody detection in Multiple Sclerosis

open access: yesMethodsX, 2015
Surface plasmon resonance technique is particularly interesting in immunology because it has the potential to visualize label-free antigen-antibody interactions in real-time, thus enabling antibody detection and monitoring.
Feliciana Real-Fernández   +4 more
doaj   +1 more source

Bioactive Peptides [PDF]

open access: yesJournal of AOAC INTERNATIONAL, 2008
Abstract Peptides with biological activities, released during gastrointestinal digestion or food processing, play an important role in metabolic regulation and modulation, suggesting their potential use as nutraceuticals and functional food ingredients for health promotion and disease risk reduction.
Fereidoon, Shahidi, Ying, Zhong
openaire   +2 more sources

Recombination of a dual-CAR-modified T lymphocyte to accurately eliminate pancreatic malignancy

open access: yesJournal of Hematology & Oncology, 2018
Background The therapeutic application of T cells endowing with chimeric antigen receptors (CARs) is faced with “on-target, off-tumor” toxicity against solid tumors, particularly in the treatment of the pancreatic cancer.
Erhao Zhang   +12 more
doaj   +1 more source

N-Acetylcysteine and Other Sulfur-Donors as a Preventative and Adjunct Therapy for COVID-19

open access: yesAdvances in Pharmacological and Pharmaceutical Sciences, 2022
The airway epithelial glycocalyx plays an important role in preventing severe acute respiratory syndrome coronavirus 2 entry into the epithelial cells, while the endothelial glycocalyx contributes to vascular permeability and tone, as well as modulating ...
Heidi N du Preez   +3 more
doaj   +1 more source

Peptide Bioinformatics- Peptide Classification Using Peptide Machines [PDF]

open access: yes, 2008
Peptides scanned from whole protein sequences are the core information for many peptide bioinformatics research such as functional site prediction, protein structure identification, and protein function recognition. In these applications, we normally need to assign a peptide to one of the given categories using a computer model.
openaire   +2 more sources

Preferred Configurations of Peptide–Peptide Interactions

open access: yesThe Journal of Physical Chemistry A, 2013
The natural and fundamental proclivities of interaction between a pair of peptide units are examined using high-level ab initio calculations. The NH···O H-bonded structure is found to be the most stable configuration of the N-methylacetamide (NMA) model dimer, but only slightly more so than a stacked arrangement.
Adhikari, U., Scheiner, Steve
openaire   +5 more sources

Crystal structure of methyl 1-(2-(fluorosulfonyl)ethyl)-2-oxocyclopentanecarboxylate, C9H13FO5S

open access: yesZeitschrift für Kristallographie - New Crystal Structures, 2017
C9H13FO5S, triclinic, P1̅ (no. 2), a = 5.9390(3) Å, b = 8.1581(4) Å, c = 11.3823(8) Å, α = 89.498(3)°, β = 85.314(5)°, γ = 84.916(5)°, V = 547.48(5) Å3, Z = 2, Rgt(F) = 0.0303, wRref(F2) = 0.0811, T = 293 K.
Govender Kimberleigh B.   +4 more
doaj   +1 more source

PKC-ζ mediated reduction of the extracellular vesicles-associated TGF-β1 overcomes radiotherapy resistance in breast cancer

open access: yesBreast Cancer Research, 2023
Background Radiotherapy is widely applied in breast cancer treatment, while radiotherapy resistance is inevitable. TGF-β1 has been considered to be an endogenous factor for the development of radiotherapy resistance.
Fayun Zhang   +7 more
doaj   +1 more source

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