Results 11 to 20 of about 2,341,910 (347)
Molecular & Cellular Proteomics, 2014 Protein quantification without isotopic labels has been a long-standing interest in the proteomics field. However, accurate and robust proteome-wide quantification with label-free approaches remains a challenge. We developed a new intensity determination
J. Cox +5 more
semanticscholar +1 more source
Quantifying systemic molecular networks affected during high altitude de-acclimatization
Scientific Reports, 2023 High altitude acclimatization and disease have been the centerpiece of investigations concerning human health at high altitude. Almost all investigations have focused on either understanding and ameliorating high altitude disease or finding better ...
Subhojit Paul +5 more
doaj +1 more source
Journal of Hematology & Oncology, 2018 Background Chimeric antigen receptors (CARs) presented on T cell surfaces enable redirection of T cell specificity, which has enormous promise in antitumor therapy.
Erhao Zhang +11 more
doaj +1 more source
Peptides, Antibodies, Peptide Antibodies and More [PDF]
International Journal of Molecular Sciences, 2019 The applications of peptides and antibodies to multiple targets have emerged as powerful tools in research, diagnostics, vaccine development, and therapeutics. Antibodies are unique since they, in theory, can be directed to any desired target, which illustrates their versatile nature and broad spectrum of use as illustrated by numerous applications of ...
Nicole Trier, Paul Hansen, Gunnar Houen
openaire +5 more sources
Peptide Stapling Applied to Antimicrobial Peptides
Antibiotics, 2023 Antimicrobial peptides (AMPs) are considered a promising therapeutic approach against multi-drug resistant microorganisms. Besides their advantages, there are limitations to be overcome so that these molecules can become market competitive. One of the biggest limitations is proteolytic susceptibility, which could be overcome by structural modifications
Ana Laura Pereira Lourenço +4 more
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Label-free method for anti-glucopeptide antibody detection in Multiple Sclerosis
MethodsX, 2015 Surface plasmon resonance technique is particularly interesting in immunology because it has the potential to visualize label-free antigen-antibody interactions in real-time, thus enabling antibody detection and monitoring.
Feliciana Real-Fernández +4 more
doaj +1 more source
Andromeda: a peptide search engine integrated into the MaxQuant environment.
Journal of Proteome Research, 2011 A key step in mass spectrometry (MS)-based proteomics is the identification of peptides in sequence databases by their fragmentation spectra. Here we describe Andromeda, a novel peptide search engine using a probabilistic scoring model. On proteome data,
J. Cox +5 more
semanticscholar +1 more source
Recombination of a dual-CAR-modified T lymphocyte to accurately eliminate pancreatic malignancy
Journal of Hematology & Oncology, 2018 Background The therapeutic application of T cells endowing with chimeric antigen receptors (CARs) is faced with “on-target, off-tumor” toxicity against solid tumors, particularly in the treatment of the pancreatic cancer.
Erhao Zhang +12 more
doaj +1 more source
Antibiotics, 2020 As natural host defense compounds produced by numerous prokaryotic and eukaryotic life forms, antimicrobial peptides (AMPs) are now emerging as solid candidate chemotherapeutic drugs to fight against the various types of pathogenic Gram-positive and Gram-negative bacteria, especially those resistant to current antibiotics [...]
openaire +4 more sources
Journal of Immunology, 2017 Cytotoxic T cells are of central importance in the immune system’s response to disease. They recognize defective cells by binding to peptides presented on the cell surface by MHC (major histocompatibility complex) class I molecules.
V. Jurtz +5 more
semanticscholar +2 more sources