Results 31 to 40 of about 3,707,949 (340)

Antisense PNA accumulates in Escherichia coli and mediates a long post-antibiotic effect [PDF]

, 2007
Antisense agents that target growth-essential genes display surprisingly potent bactericidal properties. In particular, peptide nucleic acid (PNA) and phosphorodiamidate morpholino oligomers linked to cationic carrier peptides are effective in time kill ...
Behmanesh, Mehrdad, Dryselius, Rikard, Faridani, Omid R, Ganyu, Anita, Goh, Shan, Good, Liam, Klok, Erik Jan, Nikravesh, Abbas, Sadeghizadeh, Majid, Zain, Rula   +9 more
core   +2 more sources

Cyclic homodimer formation by singlet oxygen-mediated oxidation of carnosine

Frontiers in Chemistry
Although carnosine (β-Ala-L-His) is one of physiological protectants against in vivo damages caused by reactive oxygen species (ROS), its reactivity against singlet oxygen (1O2), an ROS, is still unclear at the molecular level.
Hiroko Kawakami, Hiroko Kawakami, Yuki Itakura, Tetsuya Yamamoto, Taku Yoshiya, Taku Yoshiya   +5 more
doaj   +1 more source

C-peptide: a predictor of cardiovascular mortality in subjects with established atherosclerotic disease [PDF]

, 2017
Aim: Insulin resistance and type 2 diabetes are independent risk factors for cardiovascular diseases. Levels of C-peptide are increased in these patients and its role in the atherosclerosis progression was studied in vitro and in vivo over the past ...
Ballanti, Marta, Cardellini, Marina, Cardolini, Iris, Davato, Francesca, Farcomeni, Alessio, Federici, Massimo, Grappasonni, Giulia, Guglielmi, Valeria, Ippoliti, Arnaldo, Menghini, Rossella, Morelli, Monica, Pecchioli, Chiara, Porzio, Ottavia, Rizza, Stefano   +13 more
core   +1 more source

Discovery and characterization of prolactin neutralizing monoclonal antibodies for the treatment of female-prevalent pain disorders

mAbs, 2023
Prolactin (PRL) has recently been demonstrated to elicit female-selective nociceptor sensitization and increase pain-like behaviors in female animals.
Stephanie Maciuba, Gregory D. Bowden, Harrison J. Stratton, Kazimierz Wisniewski, Claudio D. Schteingart, Juan C. Almagro, Philippe Valadon, Joshua Lowitz, Scott M. Glaser, Grace Lee, Mahdi Dolatyari, Edita Navratilova, Frank Porreca, Pierre J.M. Rivière   +13 more
doaj   +1 more source

Novel and unscrutinized immune entities of the zebrafish gut

FEBS Letters, EarlyView.
Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil, Marine Mantel, Julia Soh, Serge Mostowy, Sylvia Brugman, Gilles Claude Vanwalleghem   +5 more
wiley   +1 more source

Ugi multicomponent reaction to prepare peptide–peptoid hybrid structures with diverse chemical functionalities [PDF]

, 2018
Monodisperse sequenced peptides and peptoids present unique nano-structures based on their self-assembled secondary and tertiary structures. However, the generation of peptide and peptoid hybrid oligomers in a sequence-defined manner via Ugi ...
Azevedo, Helena S., Barner-Kowollik, Christopher, Becer, C. Remzi, Collis, Dominic, Edwards-Gayle, Charlotte J. C., Hamley, Ian W., Hartweg, Manuel, Kaupp, Michael, Radvar, Elham, Rambo, Robert, Reza, Mehedi, Ruokolainen, Janne, Steinkoenig, Jan   +12 more
core   +1 more source

Crystal structure of 2-ethyl-1-tert-butyl-2-((4-fluorophenyl)(tert-butoxycarbonylamino)methyl)-3-oxo-pyrrolidine-1,2-dicarboxylate, C24H33FN2O7

Zeitschrift für Kristallographie - New Crystal Structures, 2016
C24H33FN2O7, triclinic, P1̅ (no. 2), a = 11.0118(7) Å, b = 11.5684(7) Å, c = 11.7276(7) Å, α = 112.294(1)°, β = 100.557(1)°, γ = 105.775(2)°, V = 1259.56(13) Å3, Z = 2, Rgt(F) = 0.0411, wRref(F2) = 0.1050, T = 173 K.
Makhathini Sifiso S., Samipillai Marivel, Govender Thavendran, Naicker Tricia   +3 more
doaj   +1 more source

Synthesis of Fully Functionalized 3-Bromoazaspiro[4.5]trienones through Ugi Four-Component Reaction (Ugi-4CR) followed by ipso-Bromocyclization

SynOpen, 2018
Biologically attractive azaspiro[4.5]trienones have been prepared via Ugi four-component reaction (Ugi-4CR) followed by bromine-mediated ipso-cyclization.
Saeed Balalaie, Hadiseh Bakhshaei Ghoroghaghaei, Nahid S. Alavijeh, Fatemeh Darvish, Frank Rominger, Hamid Reza Bijanzadeh   +5 more
doaj   +1 more source

Neutralizing Carbapenem Resistance by Co-Administering Meropenem with Novel β-Lactam-Metallo-β-Lactamase Inhibitors

Antibiotics, 2023
Virulent Enterobacterale strains expressing serine and metallo-β-lactamases (MBL) genes have emerged responsible for conferring resistance to hard-to-treat infectious diseases. One strategy that exists is to develop β-lactamase inhibitors to counter this
Nakita Reddy, Letisha Girdhari, Mbongeni Shungube, Arnoldus C. Gouws, Byron K. Peters, Kamal K. Rajbongshi, Sooraj Baijnath, Sipho Mdanda, Thandokuhle Ntombela, Thilona Arumugam, Linda A. Bester, Sanil D. Singh, Anil Chuturgoon, Per I. Arvidsson, Glenn E. M Maguire, Hendrik G. Kruger, Thavendran Govender, Tricia Naicker   +17 more
doaj   +1 more source

A Comprehensive Review on Current Advances in Peptide Drug Development and Design

International Journal of Molecular Sciences, 2019
Protein–protein interactions (PPIs) execute many fundamental cellular functions and have served as prime drug targets over the last two decades. Interfering intracellular PPIs with small molecules has been extremely difficult for larger or flat binding ...
A. Lee, J. Harris, K. Khanna, Ji-Hong Hong   +3 more
semanticscholar   +1 more source