Results 31 to 40 of about 2,341,910 (347)
Cyclic homodimer formation by singlet oxygen-mediated oxidation of carnosine
Frontiers in ChemistryAlthough carnosine (β-Ala-L-His) is one of physiological protectants against in vivo damages caused by reactive oxygen species (ROS), its reactivity against singlet oxygen (1O2), an ROS, is still unclear at the molecular level.
Hiroko Kawakami +5 more
doaj +1 more source
MSFragger: ultrafast and comprehensive peptide identification in shotgun proteomics
Nature Methods, 2017 There is a need to better understand and handle the 'dark matter' of proteomics—the vast diversity of post-translational and chemical modifications that are unaccounted in a typical mass spectrometry–based analysis and thus remain unidentified.
Andy T. Kong +4 more
semanticscholar +1 more source
eLife, 2018 Why does cancer develop in situations where the immune system is perfectly capable of eliminating it?
Jian Guan, Nilabh Shastri
openaire +4 more sources
The dual nature of TDC – bridging dendritic and T cells in immunity
FEBS Letters, EarlyView.TDC are hematopoietic cells combining dendritic and T cell features. They reach secondary lymphoid organs (SLOs) and peripheral organs (liver and lungs) after FLT3‐dependent development in the bone marrow and maturation in the thymus. TDC are activated and enriched in SLOs upon viral infection, suggesting that they might play unique immune roles, since
Maria Nelli, Mirela Kuka
wiley +1 more source
Zeitschrift für Kristallographie - New Crystal Structures, 2016 C24H33FN2O7, triclinic, P1̅ (no. 2), a = 11.0118(7) Å, b = 11.5684(7) Å, c = 11.7276(7) Å, α = 112.294(1)°, β = 100.557(1)°, γ = 105.775(2)°, V = 1259.56(13) Å3, Z = 2, Rgt(F) = 0.0411, wRref(F2) = 0.1050, T = 173 K.
Makhathini Sifiso S. +3 more
doaj +1 more source
Feedback Inhibition of CREB Signaling Promotes Beta Cell Dysfunction in Insulin Resistance
Cell Reports, 2015 Although persistent elevations in circulating glucose concentrations promote compensatory increases in pancreatic islet mass, unremitting insulin resistance causes deterioration in beta cell function that leads to the progression to diabetes.
Emilie Blanchet +6 more
doaj +1 more source
Peptide Bioinformatics- Peptide Classification Using Peptide Machines [PDF]
, 2008 Peptides scanned from whole protein sequences are the core information for many peptide bioinformatics research such as functional site prediction, protein structure identification, and protein function recognition. In these applications, we normally need to assign a peptide to one of the given categories using a computer model.
openaire +3 more sources
Preferred Configurations of Peptide–Peptide Interactions
The Journal of Physical Chemistry A, 2013 The natural and fundamental proclivities of interaction between a pair of peptide units are examined using high-level ab initio calculations. The NH···O H-bonded structure is found to be the most stable configuration of the N-methylacetamide (NMA) model dimer, but only slightly more so than a stacked arrangement.
Adhikari, U., Scheiner, Steve
openaire +6 more sources
Foods, 2017 The increased consumer awareness of the health promoting effects of functional foods and nutraceuticals is the driving force of the functional food and nutraceutical market. Bioactive peptides are known for their high tissue affinity, specificity and efficiency in promoting health.
Eric Daliri, Deog Oh, Byong Lee
openaire +3 more sources
A Comprehensive Review on Current Advances in Peptide Drug Development and Design
International Journal of Molecular Sciences, 2019 Protein–protein interactions (PPIs) execute many fundamental cellular functions and have served as prime drug targets over the last two decades. Interfering intracellular PPIs with small molecules has been extremely difficult for larger or flat binding ...
A. Lee +3 more
semanticscholar +1 more source