Results 51 to 60 of about 3,466,843 (390)
Evolutionary interplay between viruses and R‐loops
FEBS Letters, EarlyView.Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi +4 more
wiley +1 more source
Zeitschrift für Kristallographie - New Crystal Structures, 2016 C24H33FN2O7, triclinic, P1̅ (no. 2), a = 11.0118(7) Å, b = 11.5684(7) Å, c = 11.7276(7) Å, α = 112.294(1)°, β = 100.557(1)°, γ = 105.775(2)°, V = 1259.56(13) Å3, Z = 2, Rgt(F) = 0.0411, wRref(F2) = 0.1050, T = 173 K.
Makhathini Sifiso S. +3 more
doaj +1 more source
Signal Transduction and Targeted Therapy, 2021 Natural killer (NK) cells have been suggested to be associated with type 2 diabetes by regulating systemic inflammation. However, the mechanism by which NK cells regulate insulin sensitivity remains unknown. This study shows that NK-derived exosomes from
Ying Wang +8 more
doaj +1 more source
Hsc66 substrate specificity is directed toward a discrete region of the iron-sulfur cluster template protein IscU [PDF]
, 2002 Hsc66 and Hsc20 comprise a specialized chaperone system important for the assembly of iron-sulfur clusters in Escherchia coli. Only a single substrate, the Fe/S template protein IscU, has been identified for the Hsc66/Hsc20 system, but the mechanism by ...
Hoff, Kevin G. +4 more
core +1 more source
Foods, 2017 The increased consumer awareness of the health promoting effects of functional foods and nutraceuticals is the driving force of the functional food and nutraceutical market. Bioactive peptides are known for their high tissue affinity, specificity and efficiency in promoting health.
Eric Daliri, Deog Oh, Byong Lee
openaire +3 more sources
Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation
FEBS Letters, EarlyView.The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt +8 more
wiley +1 more source
Regulation of the ER stress response by a mitochondrial microprotein
Nature Communications, 2019 Cells trigger an unfolded protein response (UPR) in the endoplasmic reticulum, but its regulation by mitochondria is unclear. Here, the authors report a 54-residue microprotein PIGBOS that participates in inter-organelle contact between the endoplasmic ...
Qian Chu +12 more
doaj +1 more source
Cells, 2022 Protein phosphorylation is an essential post-translational modification that regulates multiple cellular processes. Due to their low stoichiometry and ionization efficiency, it is critical to efficiently enrich phosphopeptides for phosphoproteomics ...
Jiaran Li +8 more
doaj +1 more source
Improving binding affinity through cyclization [PDF]
, 2017 Cancer chemotherapy results in systematic damage as the drugs used are also toxic to benign tissue. Sensitizing a cancer cell to therapy by interfering with the DNA repair mechanisms would decrease overall toxicity, as the necessary dosage of ...
Abrigo, Nicolas, Newcomb, Kaylee M
core +1 more source
Candida albicans biofilm formation on peptide functionalized polydimethylsiloxane [PDF]
, 2010 In order to prevent biofilm formation by Candida albicans, several cationic peptides were covalently bound to polydimethylsiloxane (PDMS). The salivary peptide histatin 5 and two synthetic variants (Dhvar 4 and Dhvar 5) were used to prepare peptide ...
Coenye, Tom +7 more
core +1 more source