Results 111 to 120 of about 10,359,574 (255)

Computational Design and Evaluation of Peptides to Target SARS-CoV-2 Spike–ACE2 Interaction

Molecules
The receptor-binding domain (RBD) of SARS-CoV-2 spike protein is responsible for the recognition of the Angiotensin-Converting Enzyme 2 (ACE2) receptor in human cells and, thus, plays a critical role in viral infection. The therapeutic value of targeting
Saja Almabhouh, Erika Cecon, Florence Basubas, Ruben Molina-Fernandez, Tomasz Maciej Stepniewski, Jana Selent, Ralf Jockers, Amal Rahmeh, Baldo Oliva, Narcis Fernandez-Fuentes   +9 more
doaj   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

A novel chimeric peptide with antimicrobial activity

, 2015
Beta-lactamase-mediated bacterial drug resistance exacerbates the prognosis of infectious diseases, which are sometimes treated with co-administration of beta-lactam type antibiotics and beta-lactamase inhibitors.
SARIYAR AKBULUT, BERNA
core   +1 more source

Design of synthetic selenopeptides with antioxidant activity for the treatment of XP and non-melanoma skin cancer

Frontiers in Systems Biology
IntroductionXeroderma Pigmentosum (XP) is a rare, autosomal recessive disorder characterized by extreme sensitivity to ultraviolet (UV) light. Current treatments primarily focus on symptom management and surgical tumor excisions.
Arthur Alves Coelho, Arthur Alves Coelho, Eduarda Pereira Soares Dias, Eduarda Pereira Soares Dias, André Kipnis   +4 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Design Education as a Catalyst for Change

, 2018
Designers play a role in shaping our world, both literally and figuratively. Human lives are spent interacting with designed artefacts, systems, and processes.
Mulder, Ingrid, Ingrid Mulder, Milton, Alex, Alex Milton, Storni, Cristiano, Donál Holland, Cristiano Storni, Holland, Dónal, Maze, Ramia, Ramia Mazé   +9 more
core   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Designing novel peptides with amyloid-β binding and clearance potential using BiLSTM and molecular dynamics

Frontiers in Artificial Intelligence
Generative artificial intelligence is transforming de novo biomolecular design, yet developing models that reliably generate functional, target-specific peptides remains a significant challenge.
Vinod Kumar Yata, Om Pritam Das, Jarmani Dansana, Abhishikta Gadtya, Biswa Ranjan Meher, Sarad Pawar Naik Bukke, Narasaiah Kolliputi   +6 more
doaj   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source