Results 91 to 100 of about 15,341,682 (292)
Novel multi-epitope peptide vaccine design and validation using bioinformatics approach targeting MSP-1 protein of Knowlesi malaria [PDF]
Journal of Pharmacy & Pharmacognosy ResearchContext: Plasmodium knowlesi is an emerging zoonotic malaria species in Southeast Asia, challenging elimination efforts. Aims: To design a safe and immunogenic multi-epitope vaccine (MEV) targeting the merozoite surface protein-1 (MSP-1) of P ...
Biomechy Oktomalioputri +14 more
doaj +1 more source
Peptide design by optimization on a data-parameterized protein interaction landscape
Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance Medicine, agriculture, and the biofuel industry use engineered proteins to perform functions such as binding, catalysis, and signaling. Designing useful proteins faces the “needle in a haystack” problem posed by the astronomical number of ...
J. Jenson +5 more
semanticscholar +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
BiomoleculesThe increasing circulation of multi-drug-resistant pathogens, coupled with the sluggish development of new antibiotics, is weakening our capacity to combat human infections, resulting in elevated death tolls.
Bruna Agrillo +9 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Frontiers in Bioengineering and BiotechnologyPeptides are important bioactive molecules for smart biomaterials and functional tissue engineering because they can provide targeting, antimicrobial, adhesive, immunomodulatory, and differentiation-regulating functions.
Chen Ding +7 more
doaj +1 more source
Pharmaceuticals, 2014 There is great interest in the development of antimicrobial peptides as a potentially novel class of antimicrobial agents. Several structural determinants are responsible for the antimicrobial and cytolytic activity of antimicrobial peptides.
Ammar Almaaytah +6 more
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source