Results 81 to 90 of about 15,341,682 (292)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

An Enhanced Variant Designed From DLP4 Cationic Peptide Against Staphylococcus aureus CVCC 546

Frontiers in Microbiology, 2020
Insect defensins are promising candidates for the development of potent antimicrobials against antibiotic-resistant Staphylococcus aureus (S. aureus).
Bing Li, Bing Li, Na Yang, Na Yang, Xiumin Wang, Xiumin Wang, Ya Hao, Ya Hao, Ruoyu Mao, Ruoyu Mao, Zhanzhan Li, Zhanzhan Li, Zhenlong Wang, Zhenlong Wang, Da Teng, Da Teng, Jianhua Wang, Jianhua Wang   +17 more
doaj   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Design of N-Terminal Derivatives from a Novel Dermaseptin Exhibiting Broad-Spectrum Antimicrobial Activity against Isolates from Cystic Fibrosis Patients

Biomolecules, 2019
Dermaseptins are an antimicrobial peptide family widely identified from the skin secretions of phyllomeudusinae frogs. Here, we identify Dermaseptin-PC (DM-PC), from the skin secretion of Phyllomedusa coelestis, and further investigate the properties of ...
Yuan Ying, Hui Wang, Xinping Xi, Chengbang Ma, Yue Liu, Mei Zhou, Qiang Du, James F. Burrows, Minjie Wei, Tianbao Chen, Lei Wang   +10 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Natural and redesigned wasp venom peptides with selective antitumoral activity

Beilstein Journal of Organic Chemistry, 2018
About 1 in 8 U.S. women (≈12%) will develop invasive breast cancer over the course of their lifetime. Surgery, chemotherapy, radiotherapy, and hormone manipulation constitute the major treatment options for breast cancer.
Marcelo D. T. Torres, Gislaine P. Andrade, Roseli H. Sato, Cibele N. Pedron, Tania M. Manieri, Giselle Cerchiaro, Anderson O. Ribeiro, Cesar de la Fuente-Nunez, Vani X. Oliveira Jr.   +8 more
doaj   +1 more source

Structure of the EmrE multidrug transporter and its use for inhibitor peptide design

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance Bacterial pathogens are developing resistance to antibiotic compounds at an alarming rate. We use computer simulations to design inhibitors of the Escherichia coli multidrug resistance protein EmrE (efflux-multidrug resistance E) from the ...
V. Ovchinnikov, T. Stone, C. Deber, M. Karplus   +3 more
semanticscholar   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Design and Binding Affinity of Antisense Peptides for Snake Venom Neutralization

Molecules
Snakebites are a significant public health problem in many tropical and subtropical regions, causing extensive morbidity and mortality. Traditional snake antivenoms face multiple challenges, including allergenicity, high production costs, and logistical ...
Ivan Biruš, Tino Šeba, Marin Marić, Mario Gabričević, Tin Weitner   +4 more
doaj   +1 more source