Results 81 to 90 of about 10,359,574 (255)

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Novel multi-epitope peptide vaccine design and validation using bioinformatics approach targeting MSP-1 protein of Knowlesi malaria [PDF]

Journal of Pharmacy & Pharmacognosy Research
Context: Plasmodium knowlesi is an emerging zoonotic malaria species in Southeast Asia, challenging elimination efforts. Aims: To design a safe and immunogenic multi-epitope vaccine (MEV) targeting the merozoite surface protein-1 (MSP-1) of P ...
Biomechy Oktomalioputri, Kevin N. Cuandra, Aldi T. Rahman, Zaki S. Aaliyya, Enrico F. Sihombing, Farah A. Kamila, Daffa Z. Rasendriya, Rania Rofiqa, Muhammad N. Hibatullah, Ajib Z. Alamsyah, Gabriela V.P. Husodho, Muhammad F. Hamka, Vincyia Ghovanni, Fitrah Afdha, Selly Erwina   +14 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

What is sought from graphic designers? A first thematic analysis of job offers for graphic design positions in the United Kingdom

, 2016
An empirically grounded understanding about which knowledge and skills that are sought from designers is missing for a number of professional subfields of design. This gap in research challenges i) design educators in planning their educational offerings
Person, Oscar, Nicoletti Dziobczenski, Paulo, Dziobczenski, Paulo Roberto Nicoletti, Paulo Roberto Nicoletti Dziobczenski, Oscar Person   +4 more
core   +1 more source

Designing an optimized theta-defensin peptide for HIV therapy using in-silico approaches

Journal of Integrative Bioinformatics
The glycoproteins 41 (gp41) of human immunodeficiency virus (HIV), located on the virus’s external surface, form six-helix bundles that facilitate viral entry into the host cell. Theta defensins, cyclic peptides, inhibit the formation of these bundles by
Mosalanejad Zahra, Faraji Seyed Nooreddin, Rahbar Mohammad Reza, Gholami Ahmad   +3 more
doaj   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Extraction Of Defensin Antimicrobial Peptide From SWISS-PROT Database Using Extended Boyer-More Algorithm. [PDF]

, 2007
Antimicrobial Peptide (AMP) is a subset of protein that plays an essential role in innate immunity system. Researches on AMP are actively conducted in Immunology field where synthetics antibiotics are being developed. There are several classifications of
Ahamed Hassain Malim, N.H., Zainol, Zurinahni   +1 more
core   +1 more source

Synergistic antiviral effects of structure-guided peptides and a mutagenic base analog on SARS-CoV-2 replication

Antimicrobial Agents and Chemotherapy
The limited durability of vaccine protection and the rapid emergence of SARS-CoV-2 variants highlight the need for antiviral strategies that extend beyond vaccination and conventional small-molecule inhibitors. Here, we explored a dual approach combining
Sergio Ortega Del Campo, Gregorio Joaquín Fernández Ballester, Clara Blanes Mira, Víctor Guirado Osorio, Luis Díaz Martínez, Ana Isabel de Ávila, María Eugenia Soria, Brenda Martínez-González, Francisco José Villena González, Josefa Gómez-Maldonado, María Isabel Viciana Ramos, Encarnación Clavijo Frutos, Jesús L. Santos González, Ugo Bastolla, Celia Perales, Esteban Domingo, Enrique Viguera, Ana María Fernández Escamilla, Ana Grande Pérez   +18 more
doaj   +1 more source

Enhanced Antimicrobial Activity of AamAP1-Lysine, a Novel Synthetic Peptide Analog Derived from the Scorpion Venom Peptide AamAP1

Pharmaceuticals, 2014
There is great interest in the development of antimicrobial peptides as a potentially novel class of antimicrobial agents. Several structural determinants are responsible for the antimicrobial and cytolytic activity of antimicrobial peptides.
Ammar Almaaytah, Shadi Tarazi, Ahmad Abu-Alhaijaa, Yara Altall, Nizar Alshar'i, Khaldon Bodoor, Qosay Al-Balas   +6 more
doaj   +1 more source