Results 161 to 170 of about 935,615 (294)

Funneling modulatory peptide design with generative models: Discovery and characterization of disruptors of calcineurin protein-protein interactions. [PDF]

PLoS Comput Biol, 2023
Tubiana J, Adriana-Lifshits L, Nissan M, Gabay M, Sher I, Sova M, Wolfson HJ, Gal M.   +7 more
europepmc   +1 more source

An Engineered Living Material With Pro‐Angiogenic Activity Inducible by Near‐Infrared Light

Advanced Functional Materials, EarlyView.
NIR‐responsive engineered living materials (ELMs) for controlled angiogenesis: Near‐infrared (800 nm) light activates engineered probiotic bacteria within alginate‐based living materials to secrete a blood vessel‐regenerating protein. The released protein promotes pro‐angiogenic effects in endothelial networks and chick chorioallantoic membranes.
Anwesha Chatterjee, Stefanie S. M. Meier, Sara Trujillo, Andreas Möglich, Shrikrishnan Sankaran   +4 more
wiley   +1 more source

Rational peptide design for regulating liquid-liquid phase separation on the basis of residue-residue contact energy. [PDF]

Sci Rep, 2022
Kamagata K, Ariefai M, Takahashi H, Hando A, Subekti DRG, Ikeda K, Hirano A, Kameda T.   +7 more
europepmc   +1 more source

Strategies for Loading and Releasing Peptide Therapeutics in Biodegradable Carriers

Advanced Functional Materials, EarlyView.
A biodegradable carrier‐based peptide delivery system is a powerful treatment platform for diverse diseases, owing to its superior therapeutic efficacy and low toxicity. This review examines the conventional peptide‐loaded carrier fabrication process and its current limitations.
Wookyoung Jang, Ki Wan Bong
wiley   +1 more source

MOFormer: navigating the antimicrobial peptide design space with Pareto-based multi-objective transformer. [PDF]

Brief Bioinform
Wang L, Fu X, Yang J, Zhang X, Ye X, Sakurai T, Zeng X, Liu Y.   +7 more
europepmc   +1 more source

Helical structure motifs made searchable for functional peptide design. [PDF]

Nat Commun, 2022
Tsai CY, Salawu EO, Li H, Lin GY, Kuo TY, Voon L, Sharma A, Hu KD, Cheng YY, Sahoo S, Stuart L, Chen CW, Chang YY, Lu YL, Ke S, Ortiz CLD, Fang BS, Wu CC, Lan CY, Fu HW, Yang LW.   +20 more
europepmc   +1 more source

LL‐37 Driven Phase Transition and Stacking in Oligolamellar Gram‐Negative Bacterial Membrane Models

Advanced Functional Materials, EarlyView.
This work establishes oligolamellar bacterial membrane models to investigate how LL‐37 disrupts the complex dual‐bilayer architecture of Gram‐negative bacteria. Combining SAXS, cryo‐TEM, electrophoretic mobility measurements, and coarse‐grained simulations, it reveals cardiolipin‐driven phase transitions leading to bicelle‐like structures and membrane ...
Bettina Tran, Diane C.A. Lima, Linda Sandblad, Madeleine Ramstedt, Thereza A. Soares, Stefan Salentinig   +5 more
wiley   +1 more source

T cell receptor specificity landscape revealed through de novo peptide design. [PDF]

Proc Natl Acad Sci U S A
Visani GM, Pun MN, Minervina AA, Bradley P, Thomas PG, Nourmohammad A.   +5 more
europepmc   +1 more source

Amyloidogenic Peptide Fragments Designed From Bacterial Collagen‐like Proteins Form Hydrogel

Advanced Functional Materials, EarlyView.
This study identified amyloidogenic sequence motifs in bacterial collagen‐like proteins and exploited these to design peptides that self‐assemble into β‐sheet fibers and form hydrogels. One hydrogel supported healthy fibroblast growth, showing promise for biocompatible materials. Our work demonstrates that bacterial sequences can be harnessed to create
Vamika Sagar, Xuen J Ng, Lukas Lechel, Ashish Chand Rajwar, Hendrik Bargel, Abhishek A. Jalan   +5 more
wiley   +1 more source

Heuristic energy-based cyclic peptide design. [PDF]

PLoS Comput Biol
Zhu Q, Mulligan VK, Shasha D.
europepmc   +1 more source