Results 271 to 280 of about 935,022 (285)
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NANOSTRUCTURES FROM DESIGNER PEPTIDES
COSMOS, 2008The present article reviews the self-assembly of oligopeptides to form nanostructures, both in solution and in solid state. The solution structures of the peptides were examined using circular dichroism and dynamic light scattering. The solid state assembly was examined by adsorbing the peptides onto a mica surface and analyzing it using atomic force ...
BOON TEE ONG +2 more
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2013
De novo peptide design provides an efficient strategy to emulate native folding elements. Polypeptide sequences are arranged into secondary structure oligomers, which can be continuous, that is belonging to one sequence, non-covalent, but monodisperse and autonomously folded, and supramolecular leading to nanostructured assemblies, which are not ...
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De novo peptide design provides an efficient strategy to emulate native folding elements. Polypeptide sequences are arranged into secondary structure oligomers, which can be continuous, that is belonging to one sequence, non-covalent, but monodisperse and autonomously folded, and supramolecular leading to nanostructured assemblies, which are not ...
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In Silico Design of Antimicrobial Peptides
2014The rapid spread of drug-resistant pathogenic microbial strains has created an urgent need for the development of new anti-infective molecules, having different mechanism of action in comparison to existing drugs. Natural antimicrobial peptides (AMPs) represent a novel class of molecules with a broad spectrum of activity and a low rate in inducing ...
Maccari, Giuseppe +2 more
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International Journal of Peptide and Protein Research, 1993
The peptide N‐Boc‐l‐Phe‐dehydro‐Abu‐NH‐CH3 was synthesized by the usual workup procedure. The crystals grown from methanol at 4°C belong to the space group P212121 with a= 7.589(2), b= 13.690(4), c= 21.897(6) Å, Z= 4 and dc= 1.149(5) g cm−3 for C19H29N3O5·CH3OH. The peptide crystals were highly sensitive to radiation. The final agreement factor R was 0.
T.P. SINGH, P. NARULA
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The peptide N‐Boc‐l‐Phe‐dehydro‐Abu‐NH‐CH3 was synthesized by the usual workup procedure. The crystals grown from methanol at 4°C belong to the space group P212121 with a= 7.589(2), b= 13.690(4), c= 21.897(6) Å, Z= 4 and dc= 1.149(5) g cm−3 for C19H29N3O5·CH3OH. The peptide crystals were highly sensitive to radiation. The final agreement factor R was 0.
T.P. SINGH, P. NARULA
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1997
Once the characteristic frequency of the particular biological function/interaction is identified, it is possible to design an amino acid (or nucleotide) sequence that has only this spectral characteristic. We propose that this sequence designed de novo will have only the desired biological function related to the chosen characteristic frequency.
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Once the characteristic frequency of the particular biological function/interaction is identified, it is possible to design an amino acid (or nucleotide) sequence that has only this spectral characteristic. We propose that this sequence designed de novo will have only the desired biological function related to the chosen characteristic frequency.
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2012
This chapter highlights developments in peptide design over the last years to the time of its submission, with background information covering an unlimited timeframe. An emphasis is made on prescriptive or de novo design of polypeptide sequences in relation to specific folds, topologies and functions, as seen in native systems. Therefore, the choice of
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This chapter highlights developments in peptide design over the last years to the time of its submission, with background information covering an unlimited timeframe. An emphasis is made on prescriptive or de novo design of polypeptide sequences in relation to specific folds, topologies and functions, as seen in native systems. Therefore, the choice of
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Design of nonpeptides from peptide ligands for peptide receptors
2002Publisher Summary To develop nonpeptide ligands, efforts are in progress to develop templates and aspects of conformational design that permit assembling of all components necessary for molecular recognition and transduction. The proper choice of template that can place the key side chain residue in 3D space is still difficult, and thus only partial ...
Victor J, Hruby +3 more
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Design of Peptides and Proteins
1988Publisher Summary This chapter focuses on contemporary approaches to the design of structurally defined peptides and proteins with special emphasis being given to the ways in which this approach has elucidated the structural basis for the function of a variety of natural molecules.
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