Results 251 to 260 of about 15,341,682 (292)

An ingenious design for peptide vaccines

Vaccine, 2005
For humoral immunization, it may be possible to make effective and safe peptide vaccines for various diseases by selection of proper B-cell epitopes. However, a lack of T-cell epitopes on short peptides, such as those associated with major histocompatibility complex (MHC)-restriction, is a major problem for peptide vaccine development.
Akira, Yano, Atsuko, Onozuka, Yasuko, Asahi-Ozaki, Susumu, Imai, Nobuhiro, Hanada, Yoshikatsu, Miwa, Tosiki, Nisizawa   +6 more
openaire   +2 more sources

Patenting computer-designed peptides

Journal of Computer-Aided Molecular Design, 1998
The problem of designing new peptides that possess specific properties, such as bactericidal activity, is of wide interest. Recently, attention has focused on the use of Computer-Aided Molecular Design techniques in parallel with more traditional 'synthesise and test' methods.
S, Patel, I P, Stott, M, Bhakoo, P, Elliott   +3 more
openaire   +2 more sources

Design and Pharmacology of Peptide Mimetics

1995
Publisher Summary This chapter analyzes the revolutionary changes that are at the forefront of the new pharmaceutical era, and also attempts to extrapolate the likely outcomes in the not-too-distant future. Although new conceptual and technological advances in the area of biomolecule mimetics includes all conceivable types of biomolecules, the most ...
G J, Moore, J R, Smith, B W, Baylis, J M, Matsoukas   +3 more
openaire   +2 more sources

Design of metal ion binding peptides

Biopolymers, 1995
AbstractTwo cyclic and branched peptides (PLA and AZU) were synthesized with the aim of reproducing the active site of the blue copper proteins plastocyanin and azurin. Both peptides, designed on the basis of the x‐ray structures of Poplar plastocyanin and Alcaligenes denitrificans azurin.
R. FATTORUSSO, G. MORELLI, LOMBARDI, ANGELINA, NASTRI, FLAVIA, O. MAGLIO, D'AURIA, GABRIELLA, C. PEDONE, PAVONE, VINCENZO   +7 more
openaire   +4 more sources

Simulated Molecular Evolution for Anticancer Peptide Design.

Angewandte Chemie, 2019
A computational technique based on a simulated molecular evolution protocol was employed for anticancer peptide (ACP) design. Starting from known ACPs, innovative bioactive peptides were automatically generated in computer-assisted design-synthesize-test
Claudia S Neuhaus, G. Gabernet, Christian Steuer, K. Root, J. A. Hiss, R. Zenobi, G. Schneider   +6 more
semanticscholar   +1 more source

D-Flow: Multi-modality Flow Matching for D-peptide Design.

IEEE journal of biomedical and health informatics
Proteins are crucial to biological processes, and therapeutic peptides are emerging as promising pharmaceutical agents. Among these, D-peptides are resistant to proteolysis, exhibit greater in vivo stability, and are easier to synthesize.
Fang Wu, Tinson Xu, Shuting Jin, Xiangru Tang, Zerui Xu, James Zou, B. Hie   +6 more
semanticscholar   +1 more source

A Mathematical Model for Peptide Inhibitor Design

Journal of Computational Biology, 2010
Abstract This article presents a mathematical model on the design of peptide inhibitors for proteins. This model is a combination of the two rules on protein-ligand interaction, Miyazawa-Jernigan (M-J) matrix and hidden Markov model (HMM).
Xiaodong Pang, Linxiang Zhou, Mingjun Zhang, Fang Xie, Long Yu, Lili Zhang, Lina Xu, Xinyi Zhang   +7 more
openaire   +2 more sources

Molecular designer self-assembling peptides

Chemical Society Reviews, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Xiaojun, Zhao, Shuguang, Zhang
openaire   +2 more sources

Extended Concerted Rotation Technique Enhances the Sampling Efficiency of Computational Peptide-Design Algorithm

Journal of Chemical Theory and Computation, 2017
To enhance the sampling efficiency of our computational peptide-design algorithm in conformational space, the concerted rotation (CONROT) technique is extended to enable larger conformational perturbations of peptide chains.
Xingqing Xiao, Yiming Wang, J. Leonard, C. Hall   +3 more
semanticscholar   +1 more source

Challenges in the design of self replicating peptides

Organic & Biomolecular Chemistry, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
Xiangqun, Li, Jean, Chmielewski
openaire   +2 more sources