Results 241 to 250 of about 15,341,682 (292)

In Silico Design of Anticancer Peptides

2017
In the past few years, small peptides having anticancer properties have emerged as a potential avenue for cancer therapy. Compared to current anti-cancer chemotherapeutic drugs (or small molecules), anticancer peptides (ACPs) have numerous advantageous properties, such as high specificity, low production cost, high tumor penetration, ease of synthesis ...
Shailesh, Kumar, Hui, Li
openaire   +2 more sources

Computational design of peptide ligands

Trends in Biotechnology, 2011
Peptides possess several attractive features when compared to small molecule and protein therapeutics, such as high structural compatibility with target proteins, the ability to disrupt protein-protein interfaces, and small size. Efficient design of high-affinity peptide ligands via rational methods has been a major obstacle to the development of this ...
Peter, Vanhee, Almer M, van der Sloot, Erik, Verschueren, Luis, Serrano, Frederic, Rousseau, Joost, Schymkowitz   +5 more
openaire   +2 more sources

Hotspot-Driven Peptide Design via Multi-Fragment Autoregressive Extension

International Conference on Learning Representations
Peptides, short chains of amino acids, interact with target proteins, making them a unique class of protein-based therapeutics for treating human diseases. Recently, deep generative models have shown great promise in peptide generation.
Jiahan Li, Tong Chen, Shitong Luo, Chaoran Cheng, Jiaqi Guan, Ruihan Guo, Sheng Wang, Ge Liu, Jian Peng, Jianzhu Ma   +9 more
semanticscholar   +1 more source

A Designed β-Hairpin Peptide

Biochemical and Biophysical Research Communications, 1995
A synthetic octapeptide, Boc-Leu-Val-Val-D-Pro-Gly-Leu-Val-Val-OMe (1) has been designed as a model for a beta-hairpin conformation. Circular dichroism spectra in various organic solvents reveal a single negative band at 214-217 nm consistent with beta-sheet structures.
Awasthi, Satish K, Raghothama, S, Balaram, P   +2 more
openaire   +2 more sources

Designing peptide based nanomaterials

Chemical Society Reviews, 2008
This tutorial review looks at the design rules that allow peptides to be exploited as building blocks for the assembly of nanomaterials. These design rules are either derived by copying nature (alpha-helix, beta-sheet) or may exploit entirely new designs based on peptide derivatives (peptide amphiphiles, pi-stacking systems).
Ulijn, Rein V., Smith, Andrew M.
openaire   +4 more sources

Multidimensional Design of Anticancer Peptides

Angewandte Chemie International Edition, 2015
AbstractThe computer‐assisted design and optimization of peptides with selective cancer cell killing activity was achieved through merging the features of anticancer peptides, cell‐penetrating peptides, and tumor‐homing peptides. Machine‐learning classifiers identified candidate peptides that possess the predicted properties.
Lin YC, Lim YF, Russo E, Schneider P, Bolliger L, Edenharter A, Altmann KH, Halin C, Hiss JA, Schneider G   +9 more
openaire   +3 more sources

Design of Peptides and Proteins

1988
Publisher Summary This chapter focuses on contemporary approaches to the design of structurally defined peptides and proteins with special emphasis being given to the ways in which this approach has elucidated the structural basis for the function of a variety of natural molecules.
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Design of Synthetic Peptides for Diagnostics

Current Protein & Peptide Science, 2003
Due to the advantageous properties of synthetic molecules compared to biological ones biological molecules in diagnostic tests are replaced increasingly by synthetic ones, usually synthetic peptides or related molecules. The replacement of biological antigens by synthetic peptides is most advanced at present, as well as the use of site-specific ...
R H, Meloen, W C, Puijk, J P M, Langeveld, J P M, Langedijk, P, Timmerman   +4 more
openaire   +2 more sources

Cyclic Peptide Design

Methods in Molecular Biology, 2019
G. Goetz
semanticscholar   +2 more sources

Computational Design of Peptide Assemblies

Journal of Chemical Theory and Computation
With the ongoing development of peptide self-assembling materials, there is growing interest in exploring novel functional peptide sequences. From short peptides to long polypeptides, as the functionality increases, the sequence space is also expanding exponentially.
Jiwei Min, Xi Rong, Jiaxing Zhang, Rongxin Su, Yuefei Wang, Wei Qi   +5 more
openaire   +2 more sources