Results 241 to 250 of about 935,615 (294)
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2022
Novel design of proteins to target receptors for treatment or tissue augmentation has come to the fore owing to advancements in computing power, modeling frameworks, and translational successes. Shorter proteins, or peptides, can offer combinatorial synergies with dendrimer, polymer, or other peptide carriers for enhanced local signaling, which larger ...
Joseph, Dodd-O +4 more
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Novel design of proteins to target receptors for treatment or tissue augmentation has come to the fore owing to advancements in computing power, modeling frameworks, and translational successes. Shorter proteins, or peptides, can offer combinatorial synergies with dendrimer, polymer, or other peptide carriers for enhanced local signaling, which larger ...
Joseph, Dodd-O +4 more
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Chemical Reviews, 2001
The construction of complex protein folds relies on the precise conversion of a linear polypeptide chain into a compact 3-dimensional structure. The interplay of forces that link sequence and folding is intricate and yet to be firmly elucidated.
Venkatraman, Janani +2 more
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The construction of complex protein folds relies on the precise conversion of a linear polypeptide chain into a compact 3-dimensional structure. The interplay of forces that link sequence and folding is intricate and yet to be firmly elucidated.
Venkatraman, Janani +2 more
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Patenting computer-designed peptides
Journal of Computer-Aided Molecular Design, 1998The problem of designing new peptides that possess specific properties, such as bactericidal activity, is of wide interest. Recently, attention has focused on the use of Computer-Aided Molecular Design techniques in parallel with more traditional 'synthesise and test' methods.
S, Patel +3 more
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Molecular designer self-assembling peptides
Chemical Society Reviews, 2006AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Xiaojun, Zhao, Shuguang, Zhang
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Pep–Whisperer: Inhibitory peptide design
Proteins: Structure, Function, and Bioinformatics, 2022Abstract Designing peptides for protein–protein interaction inhibition is of significant interest in computer‐aided drug design. Such inhibitory peptides could mimic and compete with the binding of the partner protein to the inhibition target.
Naama Hurwitz +2 more
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Designing immunogenic peptides
Nature Chemical Biology, 2013Peptides fulfill many roles in immunology, yet none are more important than their role as immunogenic epitopes driving the adaptive immune response, our ultimate bulwark against infectious disease. Peptide epitopes are mediated primarily by their interaction with major histocompatibility complexes (T-cell epitopes) and antibodies (B-cell epitopes).
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ChemInform, 2002
Peptides have become an increasingly important class of molecules in biochemistry, medicinal chemistry, and physiology. Many naturally occurring, physiologically relevant peptides function as hormones, neurotransmitters, cytokines, and growth factors.
Michael L. Moore, Gregory A. Grant
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Peptides have become an increasingly important class of molecules in biochemistry, medicinal chemistry, and physiology. Many naturally occurring, physiologically relevant peptides function as hormones, neurotransmitters, cytokines, and growth factors.
Michael L. Moore, Gregory A. Grant
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Trends in Pharmacological Sciences, 1994
During this century, the nonpeptidic families of hormones (for example, steroids and catecholamines) have been exploited by medicinal chemists to give an array of clinically important drugs. Although peptides represent the largest class of hormonal substances, they are limited in their potential for treating a variety of diseases because of their lack ...
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During this century, the nonpeptidic families of hormones (for example, steroids and catecholamines) have been exploited by medicinal chemists to give an array of clinically important drugs. Although peptides represent the largest class of hormonal substances, they are limited in their potential for treating a variety of diseases because of their lack ...
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2002
Publisher Summary This chapter describes a systematic approach for designing potent and selective agonists for GPCRs. Sufficient and detailed experiments are provided in the chapter as a model to synthesize the peptide agonists successfully. The design of peptides resulting in potent and selective agonist activities is difficult because of several ...
Victor J, Hruby +2 more
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Publisher Summary This chapter describes a systematic approach for designing potent and selective agonists for GPCRs. Sufficient and detailed experiments are provided in the chapter as a model to synthesize the peptide agonists successfully. The design of peptides resulting in potent and selective agonist activities is difficult because of several ...
Victor J, Hruby +2 more
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Helical peptide and protein design
Current Opinion in Chemical Biology, 1999The design of dimeric coiled-coils has ultimately led to novel applications, such as self-replicating peptide systems, whereas the structural features of the less common trimeric coiled-coil continue to be elucidated. Novel topologies have been discovered in designed proteins, as exemplified by the right-handed tetrameric coiled-coil and the inverted U
C, Micklatcher, J, Chmielewski
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