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Pep–Whisperer: Inhibitory peptide design
Proteins: Structure, Function, and Bioinformatics, 2022Designing peptides for protein–protein interaction inhibition is of significant interest in computer‐aided drug design. Such inhibitory peptides could mimic and compete with the binding of the partner protein to the inhibition target.
N. Hurwitz, D. Zaidman, H. Wolfson
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Carbohydrates in peptide and protein design
Peptide Science, 2005AbstractMonosaccharides and amino acids are fundamental building blocks in the assembly of nature's polymers. They have different structural aspects and, to a significant extent, different functional groups. Oligomerization gives rise to oligosaccharides and peptides, respectively. While carbohydrates and peptides can be found conjoined in nature, e.g.,
Jensen, Knud J., Brask, Jesper
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Design of peptide and polypeptide vaccines
Current Opinion in Biotechnology, 1997Advances have been made in the development of vaccines based on synthetic peptides and polypeptides representing tumor-associated antigens and protective epitopes of viruses and parasites. Advances within the past year include the design of vaccines based on artificial proteins, for example multiantigen peptides, branched polypeptides, fusion and ...
T, Ben-Yedidia, R, Arnon
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2002
Publisher Summary This chapter describes a systematic approach for designing potent and selective agonists for GPCRs. Sufficient and detailed experiments are provided in the chapter as a model to synthesize the peptide agonists successfully. The design of peptides resulting in potent and selective agonist activities is difficult because of several ...
Victor J, Hruby +2 more
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Publisher Summary This chapter describes a systematic approach for designing potent and selective agonists for GPCRs. Sufficient and detailed experiments are provided in the chapter as a model to synthesize the peptide agonists successfully. The design of peptides resulting in potent and selective agonist activities is difficult because of several ...
Victor J, Hruby +2 more
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Full-Atom Peptide Design with Geometric Latent Diffusion
Neural Information Processing SystemsPeptide design plays a pivotal role in therapeutics, allowing brand new possibility to leverage target binding sites that are previously undruggable. Most existing methods are either inefficient or only concerned with the target-agnostic design of 1D ...
Xiangzhe Kong +3 more
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Designing immunogenic peptides
Nature Chemical Biology, 2013Peptides fulfill many roles in immunology, yet none are more important than their role as immunogenic epitopes driving the adaptive immune response, our ultimate bulwark against infectious disease. Peptide epitopes are mediated primarily by their interaction with major histocompatibility complexes (T-cell epitopes) and antibodies (B-cell epitopes).
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Full-Atom Peptide Design based on Multi-modal Flow Matching
International Conference on Machine LearningPeptides, short chains of amino acid residues, play a vital role in numerous biological processes by interacting with other target molecules, offering substantial potential in drug discovery.
Jiahan Li +7 more
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Trends in Pharmacological Sciences, 1994
During this century, the nonpeptidic families of hormones (for example, steroids and catecholamines) have been exploited by medicinal chemists to give an array of clinically important drugs. Although peptides represent the largest class of hormonal substances, they are limited in their potential for treating a variety of diseases because of their lack ...
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During this century, the nonpeptidic families of hormones (for example, steroids and catecholamines) have been exploited by medicinal chemists to give an array of clinically important drugs. Although peptides represent the largest class of hormonal substances, they are limited in their potential for treating a variety of diseases because of their lack ...
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Helical peptide and protein design
Current Opinion in Chemical Biology, 1999The design of dimeric coiled-coils has ultimately led to novel applications, such as self-replicating peptide systems, whereas the structural features of the less common trimeric coiled-coil continue to be elucidated. Novel topologies have been discovered in designed proteins, as exemplified by the right-handed tetrameric coiled-coil and the inverted U
C, Micklatcher, J, Chmielewski
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In Silico Design of Antimicrobial Peptides
2014The rapid spread of drug-resistant pathogenic microbial strains has created an urgent need for the development of new anti-infective molecules, having different mechanism of action in comparison to existing drugs. Natural antimicrobial peptides (AMPs) represent a novel class of molecules with a broad spectrum of activity and a low rate in inducing ...
Maccari, Giuseppe +2 more
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