Results 51 to 60 of about 589,641 (293)
Recent research of peptide-based hydrogel in nervous regeneration
Bioactive MaterialsNeurological disorders exert significantly affect the quality of life for patients, necessitating effective strategies for nerve regeneration. Both traditional autologous nerve transplantation and emerging therapeutic approaches encounter scientific ...
Chunmei Xie +7 more
doaj +1 more source
A peptidic hydrogel that may behave as a “Trojan Horse” [PDF]
Beilstein Journal of Organic Chemistry, 2013 A physical hydrogel prepared with the low-molecular-weight hydrogelator (LMWHG) CH2(C3H6CO-L-Phe-D-Oxd-OH)2 and water/ethanol mixture was applied as a potential “Trojan Horse” carrier into cells. By SEM and XRD analysis we could demonstrate that a fibrous structure is present in the xerogel, making a complex network. The gelator is derived from α-amino
CASTELLUCCI, NICOLA +5 more
openaire +5 more sources
Peptide-/Drug-Directed Self-Assembly of Hybrid Polyurethane Hydrogels for Wound Healing
, 2019 Drug-loading hydrogels are promising candidates in the bioengineering research field; nevertheless, hydrophobic drug loading into a hydrophilic carrier system remains unsolved and is full of challenges.
Fanjun Zhang (2590513) +4 more
core +1 more source
FEBS Open Bio, EarlyView.Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo +4 more
wiley +1 more source
GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma
FEBS Open Bio, EarlyView.GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain +11 more
wiley +1 more source
MoleculesThe bioavailability, release, and stability of pharmaceuticals under physicochemical conditions is the major cause of drug candidates failing during their clinical trials.
Adelaide R. Mashweu, Vladimir A. Azov
doaj +1 more source
Therapeutic potential of a pullulan polysaccharide-based hydrogel with antibacterial peptide for skin wound healing [PDF]
Iranian Journal of Basic Medical SciencesObjective(s): Eliminating skin defects using scaffolds, especially hydrogels, has been a promising method to accelerate regeneration. The utilization of hydrogels composed of carboxymethyl chitosan and pullulan oxide, synthesized via Schiff base reaction,
Maziar Malekzadeh +2 more
doaj +1 more source
Chemically Cross-Linked Poly(acrylic-co-vinylsulfonic) Acid Hydrogel for the Delivery of Isosorbide Mononitrate [PDF]
, 2013 We report synthesis, characterization, and drug release attributes of a series of novel pH-sensitive poly(acrylic-co-vinylsulfonic) acid hydrogels.
Talib Hussain +9 more
core +1 more source
FEBS Open Bio, EarlyView.This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli +2 more
wiley +1 more source
Peptide-Based Hydrogels and Nanogels for Delivery of Doxorubicin
International Journal of Nanomedicine, 2021 The clinical use of the antitumoral drug doxorubicin (Dox) is reduced by its dose-limiting toxicity, related to cardiotoxic side effects and myelosuppression. In order to overcome these drawbacks, here we describe the synthesis, the structural characterization and the in vitro cytotoxicity assays of hydrogels (HGs) and nanogels (NGs) based on short ...
Gallo E. +5 more
openaire +6 more sources