Results 111 to 120 of about 40,308 (299)

Highly efficient discovery of the covalent Mpro inhibitors from crude Pu-erh tea by integrating biochemical and chemoproteomic approaches

Food Science and Human Wellness
The main proteases (Mpros) are hydrolases playing essential roles in the replication of β-coronaviruses including SARS-CoV-2. Herein, a highly efficient strategy was developed for discovering the Mpro inactivators from crude plant extract integrating ...
Guanghao Zhu, Yani Zhang, Shenglan Qi, Jianrong Xu, Yuan Xiong, Zhaoqin Zhang, Xixiang Chen, Yuanyuan Xie, Xiaoqing Guan, Weidong Zhang, Wei Liu, Guangbo Ge   +11 more
doaj   +1 more source

S. aureus colonization and clinical symptoms remain stable upon topical XZ.700 treatment: Results of a double‐blind randomized clinical trial in patients with mild to moderate atopic dermatitis

British Journal of Clinical Pharmacology, EarlyView.
Aim Recovering dysbiosis may improve atopic dermatitis (AD) symptoms. XZ.700 is a recombinant chimeric endolysin that specifically targets Staphylococcus aureus and could be a new treatment option for patients with AD. The aim of this first‐in‐human study was to evaluate the safety, tolerability and efficacy of topical XZ.700 and explore the ...
Laura W. J. van der Meulen, Menthe E. Bergmans, Salma Assil, Naomi Klarenbeek, Marieke L. de Kam, Alexa J. Tibboel, Thorsten Brach, Bjorn L. Herpers, Johan Frieling, Vincent de Jong, Benthe Freyee, Martijn B. A. van Doorn, Robert Rissmann, Tessa Niemeyer–van der Kolk   +13 more
wiley   +1 more source

Nitric oxide synthase in skeletal muscle fibres of patients with type 2 diabetes [PDF]

, 2012
Muscle-derived nitric oxide (NO) mediates fundamental physiological actions on skeletal muscle including glucose uptake into muscle cells. Recently, we have shown that the altered glucose metabolism in skeletal muscle of patients with type 2 diabetes ...
Karla Punkt, Volker Adams, Katharina Kandt, Matthias Blueher, Andreas Oberbach, Igor Buchwalow   +5 more
core   +1 more source

Bacillus velezensis T971 genome informs starch degradation in tobacco

Frontiers in Microbiology
Starch is an important reserve polysaccharide in tobacco leaves. An endophytic bacterium, Bacillus velezensis T971, was isolated from the leaves of Nicotiana tabacum L. Yunyan 97 and showed strong starch-degrading activity on the agar plate containing 1%
Liwei Hu, Xinpeng Zhang, Qin Gao, Mengmeng Yang, Xiangzhou Dong, Tingming Cheng, Taibo Liang, Bingye Yang, Yanling Zhang, Yanbin Yin   +9 more
doaj   +1 more source

Affinity Peptides With pH Sensitivity for the Enrichment of CD38+ Cells

Biotechnology and Bioengineering, EarlyView.
ABSTRACT The selective enrichment of cell populations based on surface markers is critical for the advancement of gene and cell therapies. Current antibody‐based cell isolation methods, such as fluorescence‐ and magnetic‐activated cell sorting (FACS and MACS), offer high specificity but are limited by scalability, cost, and potential adverse effects on
Gabrielle Rusch, Mickael Meyer, I. Mohamed Irfan, Carson Huber, Joseph Burclaff, Scott T. Magness, Stefano Menegatti, Michael Daniele   +7 more
wiley   +1 more source

Increased levels of two distinct elastase-like hydrolases in plasma during septicemia [PDF]

, 1983
Nelles, L. P., Goldberg, David M., Schnebli, H. P., Jochum, Marianne, Duswald, Karl-Heimo   +4 more
core   +1 more source

Glycoside hydrolases from Rhodothermus marinus Modular organisation and structure-function relationships [PDF]

, 2003
The thermophilic bacterium Rhodothermus marinus produces several thermostable glycoside hydrolases. The studies presented in this thesis were performed on two enzymes, belonging to glycoside hydrolase families 10 and 12, produced by this microorganism ...
Abou-Hachem, Maher
core   +2 more sources

Impact of Agitation Power Input on Aspergillus oryzae Metabolism: Application of Multi‐Omics on an Industrial Enzyme Fermentation

Biotechnology and Bioengineering, EarlyView.
ABSTRACT The agitation power input substantially impacts the oxygen transfer rate in aerobic fermentation processes. Furthermore, in a carbon‐limited process where the substrate feed rate is controlled by the concentration of dissolved oxygen, the power input will consequently govern the feed rate.
Mariana Albino, Jean‐Marie Mouillon, Gisela Nadal‐Rey, Carina L. Gargalo, Ulrich Krühne, Krist V. Gernaey, Mads O. Albæk   +6 more
wiley   +1 more source

Polycationic Peptide Engineering of Phage Endolysins Expands Host Range and Enhances Antibacterial and Antibiofilm Activities Against Bacillus Species

Biotechnology and Bioengineering, EarlyView.
ABSTRACT The exponential rise in antimicrobial resistance has highlighted the urgent need for the development of alternative antibacterial strategies, including phage‐derived and engineered protein agents such as endolysins and artilysins. In this study, we report the rational design, expression, and functional characterization of novel artilysins ...
Farhat Ansari, Tarushi, Vandan Nagar
wiley   +1 more source

Atividade in vitro e in vivo de um novo complexo binuclear não-simétrico de cu(ii) contendo um ligante derivado do 1,4,7-triazaciclononano: promiscuidade catalítica de fosfatase e antioxidante [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemáticas. Programa de Pós-Graduação em QuímicaApresenta-se a sintese do complexo binuclear [Cu2(L)Cl3] (1) onde L e a forma desprotonada do ligante 3-[(4,7 ...
Almeida, Vicente Rodrigues de
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