Results 151 to 160 of about 60,986 (298)

The crystal structure of human transport and Golgi organization 2 homolog (TANGO2) suggests a cysteine N-terminal nucleophile (Ntn) hydrolase. [PDF]

Acta Crystallogr D Struct Biol
Zhou D, Chen L, Rose J, Wang BC.
europepmc   +1 more source

The Effects of Noise on the Juvenile Life Stage of Crustaceans: Behavioral, Cellular, and Molecular Responses in Procambarus clarkii

Integrative Zoology, EarlyView.
Juvenile Procambarus clarkii exposed to noise exhibited behavioral changes, shifts in enzymatic activity, and altered expression of stress and immune genes. The findings highlight the sensitivity of invertebrate juveniles to anthropogenic acoustic pollution.
Maria Ceraulo, Giuseppa Buscaino, Clarissa De Vita, Aiti Vizzini, Mirella Vazzana, Elena Papale, Francesco Longo, Francesco Paolo Faraone, Manuela Mauro   +8 more
wiley   +1 more source

Specificity and recognition of the ADP-ribosyl-ubiquitin modification in the DNA damage response. [PDF]

PLoS Biol
Chatrin C, Zhu K, Simmons MDR, Maginn L, Schützenhofer K, Lu Y, Đukić N, Wijngaarden S, Kloet MS, Kliza KW, Heden van Noort GJV, Filippov DV, Ahel D, Smith R, Ahel I.   +14 more
europepmc   +1 more source

Red blood cell membrane proteome as a reporter of disease severity, transfusion impact and genetic background in transfusion‐dependent β‐thalassaemia

British Journal of Haematology, EarlyView.
Summary Omics technologies have transformed research in haemoglobinopathies, yet the proteome of RBCs remains largely unexplored in transfusion‐dependent thalassaemia (TDT). In this proteomic analysis, Red blood cell (RBC) membranes from 48 adults with TDT were compared with healthy controls.
Konstantina Theocharaki, Sophia Delicou, Aikaterini Ntzoura‐Kani, Nikolaos Simantiris, Marianna Politou, Veroniki Komninaka, Martina Samiotaki, Jerome Zoidakis, Marianna H. Antonelou   +8 more
wiley   +1 more source

Crystal structure of PM1Pgh, a poly-γ-glutamate hydrolase from Bacillus phage PM1. [PDF]

Acta Crystallogr F Struct Biol Commun
Abe K, Fukui K, Ogura Y.
europepmc   +1 more source

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source

Editorial: Advancing antimicrobial strategies: nucleic acid and peptide-based approaches. [PDF]

Front Microbiol
Azevedo NF, Obuobi S, Tram NDT, Nielsen PE.   +3 more
europepmc   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Proteomic characterization of <i>Lysinibacillus</i> reveals early-stage PET biodegradation potential. [PDF]

Front Microbiol
Dudziak RB, Muñoz-Hisado V, Hidalgo-Arias A, Martínez-Carrancho M, Garcia-Lopez E, Fakhouri FM, Martinez-Alonso E, Alcázar A, Sigurbjörnsdóttir MA, Fonseca GG, Cid C.   +10 more
europepmc   +1 more source

Targeting protein–protein interactions with reversible covalent modalities: Non‐cysteine chemistries

British Journal of Pharmacology, EarlyView.
Abstract Protein–protein interactions (PPIs) are central to diverse cellular functions, and represent a rapidly expanding class of therapeutic targets. Advancements in covalent drug design have enabled small‐molecule drugs to overcome challenges associated with engaging these targets, such as limited durations of action and difficult‐to‐drug (expansive,
Ruchira Basu, Steven Fletcher
wiley   +1 more source