Results 151 to 160 of about 572,875 (296)

Boronic Acid Inhibitors of β‐Lactamases: A Promising Strategy Against Antimicrobial Resistance

Medicinal Research Reviews, EarlyView.
ABSTRACT The rise of antimicrobial resistance (AMR) poses a critical threat to global health, mostly due to the proliferation of β‐lactamases, a class of enzymes responsible for the inactivation of β‐lactam antibiotics. Among the most promising strategies to restore β‐lactam efficacy is the use of β‐lactamase inhibitors (BLIs), with boronic acid ...
Nicolò Santi, Federico Corsini, Robert A. Bonomo, Emilia Caselli, Fabio Prati   +4 more
wiley   +1 more source

Peptidoglycan Remodeling in Gram-Negative Bacteria: From Stress Adaptation to Antibiotic Tolerance and Therapeutic Targeting. [PDF]

Antibiotics (Basel)
Strohhammer T, Martorana AM, Polissi A.
europepmc   +1 more source

Artificial Intelligence‐Driven Natural Product Drug Discovery: From Computational Genome Mining to Clinical Translation

Medicinal Research Reviews, EarlyView.
ABSTRACT Natural products (NPs) have historically yielded numerous therapeutic agents, yet their integration into modern drug discovery has been constrained by chemical complexity, low abundance, laborious dereplication, and limited target annotation.
Antonio Lavecchia
wiley   +1 more source

Isosteric Engineering of Enzymes: Overcoming Activity-Stability Trade-Offs by Site-Selective CH → N Substitutions. [PDF]

Angew Chem Int Ed Engl
Abdelkader EH, Qianzhu H, Otting G, Huber T.   +3 more
europepmc   +1 more source

Aptamer–Based Targeted Protein Degradation: Mechanistic Principles, Delivery Strategies, and Translational Opportunities

Medicinal Research Reviews, EarlyView.
ABSTRACT Targeted elimination of pathogenic proteins remains a fundamental challenge in therapeutic intervention, particularly for proteins considered “undruggable” by conventional inhibition‐based approaches. Aptamer–based targeted protein degradation (TPD) has emerged as a versatile strategy that leverages the high specificity, structural ...
Ambrin Malik, Suyeon Son, Jaesung Lee, Ki Soo Park   +3 more
wiley   +1 more source

Bioinformatics-guided discovery and functional verification of fungal polyester hydrolases for polycaprolactone degradation. [PDF]

Biotechnol Rep (Amst)
Lu C, Lu C, Xiang C.
europepmc   +1 more source

Proteomic Analysis of Mixed Cell Membrane Extracts From Triple‐Negative Breast Cancer Cell Lines Revealed Broad Metabolic Reprogramming Associated With Tumor Progression

PROTEOMICS, EarlyView.
ABSTRACT Triple‐negative breast cancer (TNBC) represents the most aggressive subtype with limited therapeutic options and the poorest clinical outcomes. Using high‐resolution nUPLC‐QTOF‐MS/MS, we performed comprehensive proteomic profiling of TNBC cell lines representing disease progression stages: HCC‐1937 (stage IIB), HCC‐1599 (stage IIIA), and MDA ...
Claudia Sissely Chaviano‐Montes de Oca, Violeta Larios‐Serrato, María Luisa Labra‐Barrios, Emmanuel Ríos‐Castro, Carlos Alberto Castañón‐Sánchez, Rodolfo Moreno‐Castillo, Erika Beatriz Ángeles‐Morales, Juan Pedro Luna‐Arias   +7 more
wiley   +1 more source

The Biosynthetic Pathway for the Hybrid NRPS-NIS Siderophore Nocardichelin Contains NcdG, a Succinylase that Cleaves the Hydroxamate Bond of the Acylcadaverine Intermediate. [PDF]

ACS Chem Biol
Fisk MB, Merrick CE, Wencewicz TA, Gulick AM.   +3 more
europepmc   +1 more source

Targeted delivery of an antigenic Peptide to the endoplasmic reticulum: application for development of a Peptide therapy for ankylosing spondylitis

, 2014
The development of suitable methods to deliver peptides specifically to the endoplasmic reticulum (ER) can provide some potential therapeutic applications of such peptides.
Yu,Hui-Chun;Lu,Ming-Chi;Li,Chin;Huang,Hsien-Lu;Huang,Kuang-Yung;Liu,Su-Qin;Lai,Ning-Sheng;Huang,Hsien-Bin
core  

Proteo‐transcriptomic insights into the venom composition of the ectoparasitoid Eupelmus urozonus

Pest Management Science, EarlyView.
Integrated venom‐gland transcriptomics and venom proteomics of Eupelmus urozonus identified 316 venom proteins, including 75 secreted candidates, revealing diverse hydrolases, proteases/inhibitors and many uncharacterized effectors. Abstract BACKGROUND Ectoparasitoid venoms are ‘cocktails’ of bioactive molecules injected during oviposition to paralyze ...
Federica De Stefano, Carmen Scieuzo, Rosanna Salvia, Riccardo Moretti, Flora Cozzolino, Maria Monti, Heiko Vogel, Patrizia Falabella   +7 more
wiley   +1 more source