Current Status of Delay in Injectable Therapy among Type 2 Diabetes Mellitus Patients in South Korea: Multicenter Retrospective Study (2015–2021) [PDF]
Endocrinology and MetabolismBackground We aimed to assess the therapeutic inertia associated with injectable therapies and the factors influencing glycemic control following these therapies in patients with type 2 diabetes mellitus (T2DM) in South Korea.
Jong Han Choi +9 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2020 Pin1 is a peptidyl-prolyl cis-trans isomerase that specifically binds to a phosphorylated serine or threonine residue preceding a proline (pSer/Thr-Pro) motif and catalyzes the cis-trans isomerization of proline imidic peptide bond, resulting in ...
Xiangming Hu +2 more
doaj +1 more source
HCV IRES manipulates the ribosome to promote the switch from translation initiation to elongation. [PDF]
, 2013 The internal ribosome entry site (IRES) of the hepatitis C virus (HCV) drives noncanonical initiation of protein synthesis necessary for viral replication.
A Ben-Shem +68 more
core +1 more source
Positional proteomics reveals differences in N-terminal proteoform stability [PDF]
, 2016 To understand the impact of alternative translation initiation on a proteome, we performed a proteome-wide study on protein turnover using positional proteomics and ribosome profiling to distinguish between N-terminal proteoforms of individual genes.
Brown JL +4 more
core +2 more sources
The Contribution of Chemoattractant GPCRs, Formylpeptide Receptors, to Inflammation and Cancer
Frontiers in Endocrinology, 2020 A hallmark of inflammatory responses is leukocyte mobilization, which is mediated by pathogen and host released chemotactic factors that activate Gi-protein-coupled seven-transmembrane receptors (GPCRs) on host cell surface. Formylpeptide receptors (FPRs,
Weiwei Liang +7 more
doaj +1 more source
Kinetics of initiating polypeptide elongation in an IRES-dependent system
eLife, 2016 The intergenic IRES of Cricket Paralysis Virus (CrPV-IRES) forms a tight complex with 80S ribosomes capable of initiating the cell-free synthesis of complete proteins in the absence of initiation factors. Such synthesis raises the question of what effect
Haibo Zhang +3 more
doaj +1 more source
Biomarkers in acute coronary syndromes and their role in diabetic patients [PDF]
, 2005 Diabetic patients with acute coronary syndromes are at high risk for cardiovascular complications but risk stratification in these patients remains challenging.
Christopher Heeschen +5 more
core +1 more source
Possibilities for correcting diffuse alopecia associated with prior coronavirus infection (COVID-19)
Consilium Medicum, 2021 Diffuse alopecia (DA) is a disease characterized by a diffuse hair loss associated with alterations in physiological hair cycle due to an exposure of hair follicles to various endogenous and exogenous factors.
Natalia V. Shperling +2 more
doaj +1 more source
Expression systems for industrial Gram-positive bacteria with low guanine and cytosine content [PDF]
, 1997 Recent years have seen an increase in the development of gene expression systems for industrial Gram-positive bacteria with low guanine and cytosine content that belong to the genera Bacillus, Clostridium, Lactococcus, Lactobacillus, Staphylococcus and ...
Kleerebezem, Michiel, +2 more
core +2 more sources
Inhibition of Ovarian Cancer Growth by a Tumor-Targeting Peptide That Binds Eukaryotic Translation Initiation Factor 4E [PDF]
Clinical Cancer Research, 2009 Abstract Purpose: A critical step of protein synthesis involves the liberation of the mRNA cap-binding translation initiation factor eIF4E from 4EBP inhibitory binding proteins, and its engagement to the scaffolding protein eIF4G. eIF4E is a candidate target for cancer therapy because it is overexpressed or activated in many types of ...
Song Yi, Ko +3 more
openaire +2 more sources