Results 111 to 120 of about 1,170,213 (305)

Supramolecular Assembly of Triterpenoids: Current State and Biomedical Perspectives

Aggregate
Triterpenoids exhibit remarkable pharmacological characteristics and have garnered significant research attention, owing to their unique backbone structures and numerous modification sites. Recent advancements in supramolecular chemistry have highlighted
Jie Zhong, Juan C. Mareque‐Rivas, Xinmiao Lan, Yu‐Xiong Su   +3 more
doaj   +1 more source

Photoresponsive peptide materials: Spatiotemporal control of self-assembly and biological functions. [PDF]

Biophys Rev (Melville), 2023
Matsuura K, Inaba H.
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

An Unusual Acceleration of Amination Reactivity by the Proximal Ester Groups in Catechol Diesters: An Efficient Way for Peptide Synthesis

Precision Chemistry, 2023
An Wu, Hirotaka Ikeda, Hisashi Yamamoto
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

The Potential of Modified and Multimeric Antimicrobial Peptide Materials as Superbug Killers. [PDF]

Front Chem, 2021
Matthyssen T, Li W, Holden JA, Lenzo JC, Hadjigol S, O'Brien-Simpson NM.   +5 more
europepmc   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

A Lipid‐Sensitive Spider Peptide Toxin Exhibits Selective Anti‐Leukemia Efficacy through Multimodal Mechanisms

Advanced Science
Anti‐cancer peptides (ACPs) represent a promising potential for cancer treatment, although their mechanisms need to be further elucidated to improve their application in cancer therapy.
Peng Zhang, Wu Luo, Zixin Zhang, Mingchong Lv, Longkang Sang, Yuhan Wen, Lingxiang Wang, Changhao Ding, Kun Wu, Fengjiao Li, Yueqi Nie, Jiaoyue Zhu, Xiaofeng Liu, Yan Yi, Xiaofeng Ding, Youlin Zeng, Zhonghua Liu   +16 more
doaj   +1 more source

Optimizing lipopeptide bioactivity: The impact of non-ionic surfactant dressing

Journal of Pharmaceutical Analysis
The aim of the research is to increase the applicability of lipopeptides as drugs. To this end, non-ionic triblock copolymers, namely poloxamers, were applied. The physico-chemical properties of poloxamers vary depending on the length of the blocks.
Ágnes Ábrahám, Gergő Gyulai, Judith Mihály, Andrea Horváth, Orsolya Dobay, Zoltán Varga, Éva Kiss, Kata Horváti   +7 more
doaj   +1 more source

From structure to application: Progress and opportunities in peptide materials development. [PDF]

Curr Opin Chem Biol, 2021
Lopez-Silva TL, Schneider JP.
europepmc   +1 more source