Results 151 to 160 of about 200,834 (306)

Evolution of Multivalent Aptamer Corona for High‐Throughput Multiplexed Detection of Multiple Cancers

Advanced Science, EarlyView.
A multivalent aptamer corona is evolved via established ProteoFish‐SELEX (systematic evolution of ligands by exponential enrichment) for high‐throughput multiplexed detection of multiple cancers. Clinical validation using multivalent aptamer corona demonstrated high accuracy and specificity in multiplexed detection of ovarian, lung, and colorectal ...
Mengjie Wang, Baichuan Jin, Xin Dai, Haozhe Huang, Qiqi Liu, Jianqing Zhu, Haixing Ju, Qixun Chen, Yongmei Song, Weihong Tan, Yuan Liu   +10 more
wiley   +1 more source

Transient analysis and engineering of bacterial metabolic pathways using cell-penetrating peptide-peptide nucleic acid conjugates. [PDF]

Microb Cell Fact
Kawabuchi Y, Kobayashi S, Yu J, Kasai G, Kobe M, Suo R, Itoi S, Sode K, Muraoka T, Asano R, Mori T.   +10 more
europepmc   +1 more source

Forced Intercalation Peptide Nucleic Acid Probes for the Detection of an Adenosine-to-Inosine Modification. [PDF]

ACS Omega, 2023
Swenson CS, Argueta-Gonzalez HS, Sterling SA, Robichaux R, Knutson SD, Heemstra JM.   +5 more
europepmc   +1 more source

Detection of activating and acquired resistant mutation in plasma from EGFR-mutated NSCLC patients by peptide nucleic acid (PNA) clamping-assisted fluorescence melting curve analysis

, 2017
Chang Gon Kim, Hyo Sup Shim, Min Hee Hong, Yoon Jin, Su Jin Heo, Hyung Soon Park, Jee Hung Kim, Jin Gu Lee, Chang Young Lee, Byoung Chul Cho, Hye Ryun Kim   +10 more
openalex   +2 more sources

A Blood‐Brain Barrier‐Penetrant Ag(III) Corrole Compound Rescues Alzheimer's Disease Pathology by Targeting Aβ42‐Induced Oxidative Stress

Advanced Science, EarlyView.
The newly designed metallo‐corrole (Mor‐Cor)Ag(III) with a morpholino group exhibited promising therapeutic potential for Alzheimer's disease. It significantly reduces reactive oxygen species (ROS), decreases GFAP expression, increases neurite length, and decreases cell death compared to other similar metallo‐corroles. Abstract Alzheimer's disease (AD)
Arup Tarai, Tuhina Mitra, Tanmoy Pain, Jyotiprakash Mallick, Rwiddhi Chakraborty, Kallam Tejaswi, Swagata Ghatak, Sanjib Kar   +7 more
wiley   +1 more source

Recent Cutting-Edge Technologies for the Delivery of Peptide Nucleic Acid. [PDF]

Chemistry
Avitabile C, Cerasa MT, D'Aniello A, Saviano M, Moccia M.   +4 more
europepmc   +1 more source

Machine Learning Guides Peptide Nucleic Acid Flow Synthesis and Sequence Design. [PDF]

Adv Sci (Weinh), 2022
Li C, Zhang G, Mohapatra S, Callahan AJ, Loas A, Gómez-Bombarelli R, Pentelute BL.   +6 more
europepmc   +1 more source

IL‐4/STAT6‐signaling Influences Local Inflammation and Regeneration Processes During Acute Pancreatitis and Promotes Fibrosis by a Direct Activation of Pancreatic Fibroblasts During Chronic Pancreatitis

Advanced Science, EarlyView.
IL‐4/IL‐13/STAT6 signaling plays a crucial for the suppression of pro‐inflammation during acute pancreatitis and supports acinar cell regeneration but has only minor impact on fibrogenesis during chronic form of the disease. IL‐4/IL‐13 induce the expression of certain collagens directly in pancreatic fibroblasts via STAT6 activation, whereas ...
ElSheikh H, Salvers A, Piesker J, Buchholz S, Lange R, Ameling S, Steil L, Hammer E, Homuth G, Völker U, Bröker BM, Weiss FU, Sendler M, Glaubitz J   +13 more
wiley   +1 more source

Isoorotamide-based peptide nucleic acid nucleobases with extended linkers aimed at distal base recognition of adenosine in double helical RNA. [PDF]

Beilstein J Org Chem
Walby GD, Tessier BR, Mabee TL, Hoke JM, Bleam HM, Giglio-Tos A, Harding EE, Baskevics V, Katkevics M, Rozners E, MacKay JA.   +10 more
europepmc   +1 more source

Targeting a KRAS i-motif forming sequence by unmodified and gamma-modified peptide nucleic acid oligomers. [PDF]

Biopolymers, 2023
Sarkar S, Colón-Roura G, Pearse A, Armitage BA.   +3 more
europepmc   +1 more source