Results 151 to 160 of about 501,074 (305)

The Bioengineering of Microspheric Skin Organoids and Their Application in Drug Screening

Advanced Science, EarlyView.
A novel method for the preparation of uniform microspheric skin organoids via spinning bioreactors is developed. The organoid consists of a core‐shell structure to mimic the bilayered skin structure with the epidermis on the surface. For efficient drug screening, the organoid is equipped with a luciferase reporter to detect canonical Wnt signaling, and
Jundong Xie, Qingyang Yang, Yanan Zhang, Ke Zheng, Hongya Geng, Yaojiong Wu   +5 more
wiley   +1 more source

Enhanced the Trans‐Cleavage Activity of CRISPR‐Cas12a Using Metal‐Organic Frameworks as Stimulants for Efficient Electrochemical Sensing of Circulating Tumor DNA

Advanced Science, EarlyView.
This work designs manganese metal‐organic frameworks (Mn‐MOFs) co‐assembled with Cas12a/crRNA, enabling rapid release of Mn2⁺ under mild conditions. The MOFs‐induced proximity effect sustains Mn2⁺‐Cas12a/crRNA interactions, enhancing the trans‐cleavage activity of complex available to develop an electrochemical biosensor based on Mn‐MOFs‐enhanced ...
Shuai Wu, Yincheng Liu, Tianyu Zeng, Tianci Zhou, Yanting Sun, Ying Deng, Juan Zhang, Genxi Li, Yongmei Yin   +8 more
wiley   +1 more source

Modeling Peptide Nucleic Acid Binding Enthalpies Using MM-GBSA. [PDF]

J Phys Chem B, 2022
Goodman J, Attwood D, Kiely J, Coladas Mato P, Luxton R.   +4 more
europepmc   +1 more source

Virome and Experimental Analysis Reveal Tryptophan‐Like Dissolved Organic Matter Contributes to the Persistence of Plant Viruses in River Water

Advanced Science, EarlyView.
Tryptophan‐like dissolved organic matter (Try‐like DOM), a key component of organic matter in river ecosystems, demonstrates significant protective effects against plant viruses. The protective mechanism operates via a “swimming firewall” mode, whereby free Try‐like DOM attenuates ultraviolet (UV) radiation and scavenges reactive oxygen species ...
Yujie Wang, Ming Chen, Liu Yang, Jun Ma, Jian Tang, Shengjun Wu, Chi He, J. Paul Chen   +7 more
wiley   +1 more source

Self-Assembly of Diphenylalanine–Peptide Nucleic Acid Conjugates

ACS Omega, 2019
Dhrubajyoti Datta, Omshanker Tiwari, Manoj Kumar Gupta   +2 more
doaj   +1 more source

Forced Intercalation Peptide Nucleic Acid Probes for the Detection of an Adenosine-to-Inosine Modification. [PDF]

ACS Omega, 2023
Swenson CS, Argueta-Gonzalez HS, Sterling SA, Robichaux R, Knutson SD, Heemstra JM.   +5 more
europepmc   +1 more source

Killing two birds with one stone: a chemically plausible scheme for linked nucleic acid replication and coded peptide synthesis

, 1997
John D. Sutherland, Jonathan M. Blackburn   +1 more
openalex   +1 more source

Recent Advances in mRNA Delivery Systems for Cancer Therapy

Advanced Science, EarlyView.
This review systematically investigates the applications of mRNA therapy in cancer treatment, with particular emphasis on nonviral delivery systems, targeting strategies, stimulus‐responsive systems, and local delivery methods. Concluding with a meticulous evaluation, the review sheds light on the prevailing challenges while illuminating promising ...
Zheng Zhang, Ya‐Nan Fan, Si‐Qi Jiang, Ya‐Jing Ma, Yao‐Ru Yu, Yu‐Xin Qing, Qian‐Ru Li, Yi‐Lin Liu, Song Shen, Jun Wang   +9 more
wiley   +1 more source

Targeting a KRAS i-motif forming sequence by unmodified and gamma-modified peptide nucleic acid oligomers. [PDF]

Biopolymers, 2023
Sarkar S, Colón-Roura G, Pearse A, Armitage BA.   +3 more
europepmc   +1 more source

Detection and identification of lactic acid bacteria in milk and industrial starter culture with fluorescently labeled rRNA-targeted peptide nucleic acid probes [PDF]

, 2001
Oriane Matte-Tailliez, Pascal Quénée, Recep Çıbık, Jacques van Opstal, Fabrice Dessevre, Olivier Firmesse, Patrick Tailliez   +6 more
openalex   +1 more source