Results 161 to 170 of about 3,183,923 (247)

Ultrasound‐Activated Nanoinhibitors Blocking the Chemo‐Immune Checkpoint to Overcome Chemotherapy‐Induced Immune Resistance

Advanced Science, EarlyView.
A sono‐responsive chemo‐immune checkpoint nanoinhibitor (Sono‐TT8) co‐delivering TPZ chemotherapy and siXkr8 simultaneously kills tumor cells and blocks PS externalization, reversing chemotherapy‐induced immunosuppression and enhancing antitumor immunity. ABSTRACT Breast cancer features an immunosuppressive tumor microenvironment following chemotherapy
Yunfan Liu, Chier Du, Leilei Zhu, Hongjin An, Shengzhe Hou, Yi Lan, Xuemei Tang, Min Xu, Peng Luo, Hua Teng, Hao Yang, Xun Guo, Jianli Ren, Zhiyi Zhou   +13 more
wiley   +1 more source

Aminoglycoside-Peptide Nucleic Acid (PNA) Conjugates against Gram-Negative Bacteria. [PDF]

Bioconjug Chem
Siekierska I, Trylska J.
europepmc   +1 more source

Development of peptide nucleic acid-based bead array technology for Bacillus cereus detection. [PDF]

Sci Rep, 2023
Noppakuadrittidej P, Charlermroj R, Makornwattana M, Kaew-Amdee S, Waditee-Sirisattha R, Vilaivan T, Praneenararat T, Karoonuthaisiri N.   +7 more
europepmc   +1 more source

Targeted Lysosomal Degradation of Extracellular and Membrane Proteins: From Receptor Hijacking to Programmable Endolysosomal Routing

Advanced Science, EarlyView.
Targeted chimeric degraders engage extracellular or membrane proteins and endocytosable cell‐surface receptors, forming ternary complexes that induce receptor‐mediated internalization. Following endocytosis, post‐endocytic sorting—not internalization alone—determines target fate.
Ke Liu, Xiyan Wang, Xiaozhen Liu, Chaoqi He, Da Qian, Xuli Meng, Liquan Zhu   +6 more
wiley   +1 more source

Designing Programmable Peptide Nucleic Acid-based Nanovaccines for Anticancer Immune Activation. [PDF]

Small
Huang Y, Huang C, Pandita S, Ieong CM, Wang Y, Wang D, Chen J, Jauregui-Matos V, Beelen AMA, Shiau YP, Tang S, Zhao J, Zong Q, Tang M, Cong Z, Li Y, Beal PA, David SS, Wang A, Wang D, Xiao Z, Lam KS.   +21 more
europepmc   +1 more source

Triplex-Forming Peptide Nucleic Acid Controls Dynamic Conformations of RNA Bulges. [PDF]

J Am Chem Soc, 2023
Ryan CA, Rahman MM, Kumar V, Rozners E.
europepmc   +1 more source

Mitochondria‐Targeted Nanotherapeutics: A Promising Strategy in Modulating Mitochondrial Function, Transfer, and Transplantation

Advanced Science, EarlyView.
This review summarizes the pathogenic role of mitochondria in diseases and highlights mitochondrial transfer and transplantation as emerging therapeutic strategies. It systematically discusses how nanomaterials are engineered to facilitate these processes, and critically examines the current challenges and future perspectives for their clinical ...
Yuanyuan Su, Zhiyan Gong, Jiao Mu, Lili Huang, Pengfei Yang, Chenli Zhang, Lingshan Zhao, Liling Yang, Jun Deng, Xiaohui Liao   +9 more
wiley   +1 more source

Smartphone-Based Peptide Nucleic Acid (PNA) Probe-Assisted Potentiometric Biosensor for Point-of-Care Testing of SARS-CoV-2 Nucleic Acid. [PDF]

Anal Chem
Ozer T, Jampasa S, Lomae A, Ruecha N, Sagdic O, Vilaivan T, Henry CS, Chailapakul O.   +7 more
europepmc   +1 more source

Pathological Signal‐Responsive Nanoplatforms for Sepsis: Integrating Biomarker Sensing With Spatiotemporal Drug Delivery and Immunomodulation

Advanced Science, EarlyView.
Biomarker‐triggered nanoplatforms transform sepsis therapy by coupling pathological sensing with precision drug release. This review reveals how microenvironment‐responsive nanomedicines enable stage‐specific intervention, improve therapeutic efficacy, and minimize systemic toxicity, while highlighting emerging opportunities for AI‐assisted and ...
Yukun Liu, Kang Wang, Kwet Kyawl Yan, Zhikai Xu, Xuan Zhao, Xiangjun Bai, Zhanfei Li, Yuchang Wang   +7 more
wiley   +1 more source

Shelf-life extension of lettuce using cell-penetrating peptide-peptide nucleic acid conjugates targeting <i>Sphingomonas</i> <i>paucimobilis</i>. [PDF]

Curr Res Food Sci
Yum SJ, Yu SY, Kim SM, Ku S, Jeong HG.
europepmc   +1 more source