Results 161 to 170 of about 686,761 (347)
Solid-phase synthesis of negatively charged pna decamer with GlyψL-Glu pseudopeptide bond.
Тонкие химические технологии, 2007 Solid-phase Boc-protocol and synthetic strategy of negatively charged peptide nucleic acids has been suggested. New thymine containing negatively charged PNA decamer based on L-glutamic acid and glycine was synthesized.
N. P. Boyarskaya +3 more
doaj
Inhibition of telomerase activity by a cell‐penetrating peptide nucleic acid construct in human melanoma cells [PDF]
, 2000 Raffaella Villa +5 more
openalex +1 more source
Advanced Materials Interfaces, Volume 12, Issue 7, April 7, 2025.This study introduces a hybrid conjugation strategy for immobilizing low‐solubility proteins on SWCNTs to enhance fluorescent detection of protease activity. By combining covalent conjugation with non‐covalent polymer wrapping, the method achieves a threefold sensitivity increase, detecting protease activity in 5 minutes for ECM degrading enzymes and ...
Sepehr Hejazi +5 more
wiley +1 more source
Enhanced Sampling Algorithms [PDF]
arXiv, 2010 In biomolecular systems (especially all-atom models) with many degrees of freedom such as proteins and nucleic acids, there exist an astronomically large number of local-minimum-energy states. Conventional simulations in the canonical ensemble are of little use, because they tend to get trapped in states of these energy local minima.
arxiv
Advanced Materials Interfaces, Volume 12, Issue 8, April 21, 2025.This experiment investigates the development of a highly sensitive biosensor platform incorporating AuNPs with TiO2‐NTs as electrode materials. Robust PNA probes and an optimized hybridization protocol are employed to enhance performance. An appropriate level of AuNPs on the surface effectively prevents non‐specific binding of target DNA fragments ...
Younghwan Kim, Swomitra Kumar Mohanty
wiley +1 more source
PNA-Pdx: Versatile Peptide Nucleic Acid-Based Detection of Nucleic Acids and SNPs. [PDF]
Anal Chem, 2023 Jiang W +4 more
europepmc +1 more source
Applications of Enhanced Sampling Methods to Biomolecular Self-Assembly: A Review [PDF]
arXivThis review article discusses some common enhanced sampling methods in relation to the process of self-assembly of biomolecules. An introduction to self-assembly and its challenges is covered followed by a brief overview of the methods and analysis for replica-exchange molecular dynamics, umbrella sampling, metadynamics, and machine learning based ...
arxiv
Adjusting Cell‐Surface Interactions Through a Covalent Immobilization of Biomolecules
Advanced Materials Interfaces, EarlyView.This review presents an overview of current and emerging immobilization techniques coupled with an in‐depth investigation of the underlying mechanisms governing the activity and stability of covalently immobilized biomolecules. The aim of this study is to serve as a guide for the development of long‐lasting biomedical coatings with versatile biological
Sara Shakibania +2 more
wiley +1 more source
Peptide Nucleic Acids: On the Road to New Gene Therapeutic Drugs [PDF]
, 2000 Peter Nielsen
openalex +1 more source
Advanced Materials Technologies, Volume 10, Issue 6, March 18, 2025.This review focuses on the application of synthetic biodegradable microarray patches (MAPs) in sustained drug delivery. Compared to conventional MAPs which release drugs into the skin in an immediate manner, these implantable MAPs release drugs into skin microcirculation gradually as the biodegradable polymers degrade, thus offering sustained release ...
Li Zhao +6 more
wiley +1 more source