Results 181 to 190 of about 134,053 (282)

BRD4 Signaling Maintains the Differentiated State of β Cells

open access: yesAdvanced Science, EarlyView.
The comprehensive exploration revealed the critical role of BRD4 in β cells. BRD4 plays a fundamental role in maintaining β cell differentiation because both long‐term and acute BRD4 deficiency result in a reduction in insulin secretion and downregulation of differentiation markers.
Fuqiang Liu   +22 more
wiley   +1 more source

Nanomechanical assay for ultrasensitive and rapid detection of SARS-CoV-2 based on peptide nucleic acid. [PDF]

open access: yesNano Res, 2023
Wang Y   +9 more
europepmc   +1 more source

Microfluidic Biochip‐Based Multiplexed Profiling of Small Extracellular Vesicles Proteins Integrated with Machine Learning for Early Disease Diagnosis

open access: yesAdvanced Science, EarlyView.
This study develops a diagnostic platform for early detection of esophageal squamous cell carcinoma (ESCC) by integrating a barcode immunoassay biochip with machine learning. The biochip captures and analyzes small extracellular vesicle proteins from serum samples, identifying nine biomarkers linked to ESCC.
Xue Zhang   +14 more
wiley   +1 more source

Novel Small Multilamellar Liposomes Containing Large Quantities of Peptide Nucleic Acid Selectively Kill Breast Cancer Cells. [PDF]

open access: yesCancers (Basel), 2022
Proshkina G   +8 more
europepmc   +1 more source

Development of a DNA Aptamer‐Based Approach to Noninvasively Image CAR‐T Cells In Vivo and Traceless Enrichment In Vitro

open access: yesAdvanced Science, EarlyView.
A DNA aptamer (A3) with nanomolar affinity for CAR‐T cells is developed via Cell‐SELEX. In Nalm6 tumor‐bearing mice, Cy5‐labeled A3 enables long‐term fluorescence imaging and tracks the biodistribution of CAR‐T cells, with tumor signal peaking on day 14 after CAR‐T cell administration.
Minghui Chen   +8 more
wiley   +1 more source

Cyclopentane peptide nucleic acid: Gold nanoparticle conjugates for the detection of nucleic acids in a microfluidic format. [PDF]

open access: yesBiopolymers, 2022
Amarasekara H   +6 more
europepmc   +1 more source

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