Opportunities in Therapeutic mRNA Stabilization: Sequence, Structure, Adjuvants and Vectors
Advanced Therapeutics, EarlyView.Current mRNA lipid nanoparticles rely on cold storage, which increases the cost and reduces access to the vaccines. As mRNA expands to other clinical opportunities, better methods to stabilize the medicines during shipping, storage, and delivery are needed.
Joshua A. Choe +4 more
wiley +1 more source
Triplex-Forming Peptide Nucleic Acid Controls Dynamic Conformations of RNA Bulges. [PDF]
J Am Chem Soc, 2023 Ryan CA, Rahman MM, Kumar V, Rozners E.
europepmc +1 more source
Emerging Therapeutic Strategies for Hearing Loss
Advanced Therapeutics, EarlyView.Challenges still exist in treating hearing loss in cases of severe damage to hair cells or spiral ganglion neurons. Here, a schematic diagram of cochlear sensory hair cells and auditory nerves is presented. It is found that in normal Corti organs, hair cells have upright stereocilia at the top and auditory neurons at the base. Ototoxic drugs, noise, or
Shanying Han +9 more
wiley +1 more source
Hydrophobin‐Coated Echogenic Microbubbles for Molecular Targeting of Tumor Cells
Advanced Science, EarlyView.Echogenic microbubbles based on hydrophobin and corresponding fusion protein (HFBI‐domZ) are developed as contrast agents for cancer diagnostics. Hydrophobin provides high stabilization of encapsulated perfluoro‐n‐butane, and fusion proteins allow further versatile functionalization with antibodies. In‐vitro experiments indicate that these microbubbles
Hedar H. Al‐Terke +8 more
wiley +1 more source
Modeling Peptide Nucleic Acid Binding Enthalpies Using MM-GBSA. [PDF]
J Phys Chem B, 2022 Goodman J +4 more
europepmc +1 more source
FUS Selectively Facilitates circRNAs Packing into Small Extracellular Vesicles within Hypoxia Neuron
Advanced Science, EarlyView.This study aimed to unravel the role of FUS in the loading of functional circRNAs into neuronal sEVs under hypoxic conditions, which involves their aggregations in SGs and specific interaction between the FUS Zf_RanBP domain to regulate circRNA sorting in sEVs.
Jiankun Zang +14 more
wiley +1 more source
Forced Intercalation Peptide Nucleic Acid Probes for the Detection of an Adenosine-to-Inosine Modification. [PDF]
ACS Omega, 2023 Swenson CS +5 more
europepmc +1 more source
The Placenta Regulates Intrauterine Fetal Growth via Exosomal PPARγ
Advanced Science, Volume 12, Issue 15, April 17, 2025.The placenta expresses much higher levels of PPARγ than fetal adipose tissue. Trophoblastic exosomes transport PPARγ into fetal preadipocytes via fetoplacental circulation and thus regulate adipogenic genes distinct from endogenous PPARγ. Compromised placental PPARγ leads to fetal adipogenesis deficiency and intrauterine growth restriction, reversible ...
Xiaofang Luo +17 more
wiley +1 more source
Targeting a KRAS i-motif forming sequence by unmodified and gamma-modified peptide nucleic acid oligomers. [PDF]
Biopolymers, 2023 Sarkar S +3 more
europepmc +1 more source