Results 191 to 200 of about 200,834 (306)

Peptides before and during the nucleotide world: an origins story emphasizing cooperation between proteins and nucleic acids

, 2022
Stephen D. Fried, Kosuke Fujishima, Mikhail Makarov, Ivan Cherepashuk, Klára Hlouchová   +4 more
openalex   +2 more sources

Nanoparticle Immunoadjuvant Complexes Augment Germinal Center Responses to Vaccination

Advanced Science, EarlyView.
Scaffolding IL‐21 on the surface of a self‐assembling nanoparticle immunogen drives improved germinal center and humoral immune responses. These nanoparticle immunoadjuvant complexes (NICs) functionally modulate the germinal center driving improved somatic hypermutation and antibody maturation, suggesting this platform has potential utility as a ...
Nicholas J. Tursi, Colby J. Agostino, Jinwei Huang, Toshitha Kannan, Niklas Laenger, Jennifer Londregan, Katlyn Lederer, Michaela Helble, Nicole Bedanova, Cory Livingston, Ebony N. Gary, Madison McCanna, Marta Tarquis Medina, Rumi Habib, Ignacio Rodriguez Relaño, Ivan Maillard, Ami Patel, David Allman, Andrew Kossenkov, Amelia Escolano, Daniel W. Kulp, David. B. Weiner   +21 more
wiley   +1 more source

Construction of Graphene Oxide Probes Loaded with Antisense Peptide Nucleic Acid and Doxorubicin for Regulating Telomerase Activity and Inducing Apoptosis of Cancer Cells. [PDF]

Biosensors (Basel)
Zhu Y, Ji Q, Hong M.
europepmc   +1 more source

MARPLE: A Proximity‐Triggered CRISPR‐Cas13 Platform for Ultrasensitive Antibody Detection

Advanced Science, EarlyView.
MARPLE is a modular CRISPR‐Cas13 immunoassay that uses antibody‐induced proximity to trigger a toehold‐exchange reaction, releasing an RNA activator for Cas13. This one‐pot, isothermal architecture enables ultrasensitive (femtomolar) and highly specific detection of diverse antibodies, including therapeutic, pathogen‐specific, and cancer‐associated ...
Elena Spezzani, Luca Capelli, Denise Di Lena, Alejandro Chamorro‐Garcia, Rudy Ippodrino, Alessandro Porchetta, Alessandro Bertucci   +6 more
wiley   +1 more source

Peptide Nucleic Acid-Mediated Regulation of CRISPR-Cas9 Specificity. [PDF]

Nucleic Acid Ther
Carufe KEW, Economos NG, Glazer PM.
europepmc   +1 more source

A Modular DNAzyme for Precise Visualization and Intervention of Alternative Splicing Isoforms in Live Cells

Advanced Science, EarlyView.
A Stringent dUPlex‐activated Error Robust (SUPER) DNAzyme system enables real‐time imaging of alternative mRNA splicing (e.g., Bcl‐xL/Bcl‐xS) in living cells via target‐triggered split‐DNAzyme reassembly and dual‐color fluorescence. It also achieves mRNA‐selective knockdown through DNAzyme‐based gene regulation, serving as a versatile tool for splicing
Mengru Lin, Jiale Sun, Yuqing Mao, Yuhao Tang, Fuan Wang, Zhihong Liu, Jing Wang   +6 more
wiley   +1 more source

Peptide nucleic acid (PNA) clamps reduce amplification of host chloroplast and mitochondria rRNA gene sequences and increase detected diversity in 16S rRNA gene profiling analysis of oak-associated microbiota. [PDF]

Environ Microbiome
Hussain U, Downie J, Ellison A, Denman S, McDonald J, McDonald J, Cambon MC.   +6 more
europepmc   +2 more sources

Luminescent Iridium-Peptide Nucleic Acid Bioconjugate as Photosensitizer for Singlet Oxygen Production toward a Potential Dual Therapeutic Agent. [PDF]

Inorg Chem
Dell'Acqua RM, Schifano V, Dozzi MV, D'Alfonso L, Panigati M, Rusmini P, Piccolella M, Poletti A, Cauteruccio S, Maggioni D.   +9 more
europepmc   +1 more source

Rapid identification of Stenotrophomonas maltophilia by peptide nucleic acid fluorescence in situ hybridization

, 2014
Nana Wesley Hansen, Anders Rasmussen, Mark J. Fiandaca, Kasper Nørskov Kragh, Thomas Bjarnsholt, Niels Høiby, Henrik Stender, Luca Guardabassi   +7 more
openalex   +1 more source

Les PNA(peptide nucleic acids): Des sondeshigh-techpour l’analyse génétique et cytogénétique moléculaire [PDF]

, 2005
Franck Pellestor, Pétra Paulasova, Milan Macek, S. Hamamah   +3 more
openalex   +1 more source