Results 211 to 220 of about 3,183,923 (247)

Peptide nucleic acid-immobilised paper combined with multiplex recombinase polymerase amplification for the ultrasensitive and rapid detection of rifampicin-resistant tuberculosis. [PDF]

Sci Rep
Jirakittiwut N, Sathianpitayakul P, Santanirand P, Akeda Y, Vilaivan T, Ratthawongjirakul P.   +5 more
europepmc   +1 more source

Interpretability and Representability of Commutative Algebra, Algebraic Topology, and Topological Spectral Theory for Real‐World Data

Advanced Intelligent Discovery, EarlyView.
This article investigates how persistent homology, persistent Laplacians, and persistent commutative algebra reveal complementary geometric, topological, and algebraic invariants or signatures of real‐world data. By analyzing shapes, synthetic complexes, fullerenes, and biomolecules, the article shows how these mathematical frameworks enhance ...
Yiming Ren, Guo‐Wei Wei
wiley   +1 more source

Supramolecular Assembly of an Antimicrobial Peptide Into a Pore

Angewandte Chemie, EarlyView.
Supramolecular assembly of an AMP is linked to transport across the Staphylococcus aureus membrane. ABSTRACT Antimicrobial peptides (AMPs) have long been ascribed the ability to form pores. These structures, some observed, others inferred, vary in their mechanisms of action, though most are associated with lysis.
Kathyana Deeyagahage, Poonam Dhindwal, Michal T. Boniecki, Antonio Ruzzini   +3 more
wiley   +2 more sources

Ligand‐Directed Molecular Beacons as Turn‐On Fluorescent Probes for Sensing Cell‐Surface Receptor‐Ligand Interactions

Angewandte Chemie, EarlyView.
Multivalent, ligand‐directed molecular beacons enable fluorescence turn‐on detection of cell‐surface receptors in living cells. The probes strongly engage closely spaced membrane receptors and exhibit conformation‐dependent fluorescence enhancement at the cell surface, enabling wash‐free receptor imaging, inhibitor screening, and functional evaluation ...
Noa Oppenheimer‐Low, Denis Shpalter, Suraj Toraskar, Martín López‐Vidal, Ziv Porat, Inna Goliand, Ekaterina Petrovich‐Kopitman, Noga Kozer, Haim Michael Barr, Alla H. Falkovich, Leila Motiei, David Margulies   +11 more
wiley   +2 more sources

Electrophoretically Snagging Viral Genomes in Wormlike Micelle Networks Using Peptide Nucleic Acid Amphiphiles and dsDNA Oligomers. [PDF]

Biomacromolecules
Hui K, Yan L, Schneider JW.
europepmc   +1 more source

Peptide nucleic acid (PNA) clamps reduce amplification of host chloroplast and mitochondria rRNA gene sequences and increase detected diversity in 16S rRNA gene profiling analysis of oak-associated microbiota. [PDF]

Environ Microbiome
Hussain U, Downie J, Ellison A, Denman S, McDonald J, McDonald J, Cambon MC.   +6 more
europepmc   +2 more sources

Investigating Bacterial Vaginosis Pathogenesis Using Peptide Nucleic Acid-Fluorescence <i>In Situ</i> Hybridization With a Focus on the Roles of <i>Gardnerella</i> Species, <i>Prevotella bivia</i>, and <i>Fannyhessea vaginae</i>. [PDF]

Open Forum Infect Dis
George SD, Amerson-Brown MH, Sousa LGV, Carter TM, Rinehart AH, Riegler AN, Leal SM, Aaron KJ, Hao J, Tamhane A, Dong C, Lammons JW, Elnaggar JH, Graves KJ, Łaniewski P, Herbst-Kralovetz MM, Taylor CM, Cerca N, Muzny CA.   +18 more
europepmc   +1 more source

Peptide nucleic acid-assisted generation of targeted double-stranded DNA breaks with T7 endonuclease I. [PDF]

Nucleic Acids Res
Aman R, Syed MM, Saleh A, Melliti F, Gundra SR, Wang Q, Marsic T, Mahas A, Mahfouz MM.   +8 more
europepmc   +1 more source

Mechanical Caging of Nucleic Acids Enabled by Light‐Activated Synthetic Molecular Motors

Angewandte Chemie, EarlyView.
A synthetic light‐driven molecular motor imposes mechanical constraints on nucleic acids, enabling “mechanical caging” as a new mode to regulate DNA structure and function through mechanical input rather than chemical masking. ABSTRACT Control over nucleic acid activity is central to biotechnology and therapeutic development.
Yuchen Ma, Erika McCarthy, N. Sanjeeva Murthy, Cameron McGovern, Zhenyu Han, Şölen Ekesan, Subhajit Nandi, Advik Sirimarapu, Wilma K. Olson, Darrin M. York, Yuwei Gu   +10 more
wiley   +1 more source

Biotin‐ and Chloroalkane‐Modified Nucleotides for Dual Display of Proteins on DNA Through Streptavidin and Halotag Binding

Angewandte Chemie, EarlyView.
Modified 2’‐deoxy‐7‐deazaadenosine bearing a chlorohexyl moiety and 2’‐deoxycytidine nucleotides bearing biotin were used in the enzymatic synthesis of dually modified dsDNAs that served as scaffolds for display of halotag and monomeric streptavidin proteins.
Giammarco Liuni, Lenka Poštová Slavětínská, Miroslav Hájek, Veronika Raindlová, Michal Hocek   +4 more
wiley   +1 more source