Results 211 to 220 of about 209,856 (252)

Nucleobase Modified Peptide Nucleic Acid

Nucleosides, Nucleotides and Nucleic Acids, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
R H E, Hudson, R D, Viirre, N, McCourt, J, Tse   +3 more
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Peptide-Templated Nucleic Acid Ligation

Journal of Molecular Evolution, 2003
Short oligonucleotide and peptide replicators have been described. To determine whether cross-replication could have occurred between such systems, we have attempted to show that peptides can specifically template the ligation of nucleic acids. A complex between a 35-mer anti-Rev RNA aptamer and a 17-mer arginine-rich motif (ARM) peptide from the HIV-1
Matthew, Levy, Andrew D, Ellington
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Synthesis of Peptide Nucleic Acid–Peptide Conjugates

2004
Synthetic oligonucleotides are versatile tools for recognizing ribonucleic acid and deoxyribonucleic acid. This chapter describes methods for enhancing recognition by derivatizing oligonucleotides with either proteins or peptides.
Kunihiro, Kaihatsu, David R, Corey
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Nucleobase Modifications in Peptide Nucleic Acids

Current Topics in Medicinal Chemistry, 2007
Peptide nucleic acid (PNA) is an oligonucleotide mimic originally designed upon a repeating N-(2-aminoethyl)glycine polyamide backbone to which nucleobase heterocycles are attached through a methylene carbonyl linkage to the alpha-amino group. These molecules possess remarkable hybridization properties with DNA or RNA forming complexes with high ...
Filip, Wojciechowski, Robert H E, Hudson
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Antisense properties of peptide nucleic acids

Frontiers in Bioscience, 1999
PNA is a nucleic acid analog with an achiral polyamide backbone consisting of N-(2-aminoethyl)glycine units (figure 1). The purine or pyrimidine bases are linked to the each unit via a methylene carbonyl linker (1-3) to target the complementary nucleic acid (4).
U, Soomets, M, Hällbrink, U, Langel
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Pretargeting using peptide nucleic acid

Cancer, 1997
Pretargeting studies in animals and humans have usually involved (strept)avidin and biotin. Depending on the particular strategy, endogenous biotin can adversely influence localization when these molecules are used.As an alternative to (strept)avidin and biotin, we have explored the use of a single-stranded peptide nucleic acid (PNA) bound to a protein
M, Rusckowski, T, Qu, F, Chang, D J, Hnatowich   +3 more
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Peptide Nucleic Acids [PDF]

, 1998
A novel class of compounds, known as peptide nucleic acids, bind complementary ssDNA and RNA strands more strongly than a corresponding DNA. The peptide nucleic acids generally comprise ligands such as naturally occurring DNA bases attached to a peptide backbone through a suitable linker.
Buchardt, Ole, Engholm, Michael, Nielsen, Peter E., Berg, Rolf Henrik   +3 more
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Peptide nucleic acid and amino acid modified peptide nucleic acid analysis by capillary zone electrophoresis

ELECTROPHORESIS, 2019
AbstractA rapid, high resolution, and low sample consumption CZE method is developed for peptide nucleic acid (PNA) analysis for the first time. 30% v/v acetonitrile in PNA sample and 20% v/v acetonitrile in 50 mM borax‐boric acid (pH 8.7) as BGE were employed after optimization.
Xiaoqian Wang, Linsen Li, Rizwan Ullah Khan, Feng Qu   +3 more
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Peptide Nucleic Acids

2010
PNA, antisense, antigene ...
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Peptide nucleic acids as therapeutic agents

Current Opinion in Structural Biology, 1999
Peptide nucleic acids (PNAs) have been around for more than seven years and it was hoped, at their introduction, that they would quickly enter the fields of antisense and antigene technology and drug development. Despite their extremely favorable hybridization and stability properties, as well as the encouraging antisense and antigene activity of PNA ...
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