Results 221 to 230 of about 765,071 (332)

Highly Sensitive and Quantitative Detection of Mutations in v-Ki-ras2 Kirsten Rat Sarcoma Viral Oncogene by Quantitative Real-Time Polymerase Chain Reaction and Direct Sequencing With Peptide Nucleic Acid-Mediated Polymerase Chain Reaction Clamping [PDF]

, 2012
Arizumi Kikuchi, Takahiro Sawamura, Yuko Wakayama, Hiroya Sakuma, Toshio Katoh, Osami Daimaru, Takeo Nakakita, Shinichi Itoh   +7 more
openalex   +1 more source

Intracellular delivery of antisense peptide nucleic acid by fluorescent mesoporous silica nanoparticles.

Bioconjugate chemistry, 2014
Xing Ma, Gitali Devi, Qiuyu Qu, Desiree-Faye Kaixin Toh, Gang Chen, Yanli Zhao   +5 more
semanticscholar   +1 more source

Lactate Metabolic Reprogramming Mediated by CircRNA–LDHA Complex Facilitates Innate Immune Evasion of Liver Cancer

Advanced Science, EarlyView.
CircSMPD4 physically combines with lactate dehydrogenase A (LDHA) and reduces its acetylation level via SIRT2‐dependent deacetylation, thereby inhibiting chaperone‐mediated autophagy‐lysosome degradation of LDHA. Upregulating LDHA leads to increasing lactate production and extracellular export, which in turn suppresses natural killer cell cytotoxicity ...
Hao Shen, Boqiang Liu, Jing He, Weijun Zhao, Weiqi Li, Lingfeng Ma, Lidan Hou, Yi Wang, Chenqi Jin, Yushun Chang, Jie Lin, Jia Zhao, Binghan Jin, Yuanshi Tian, Xiujun Cai, Liang Shi, Yifan Wang   +16 more
wiley   +1 more source

Construction of Graphene Oxide Probes Loaded with Antisense Peptide Nucleic Acid and Doxorubicin for Regulating Telomerase Activity and Inducing Apoptosis of Cancer Cells. [PDF]

Biosensors (Basel)
Zhu Y, Ji Q, Hong M.
europepmc   +1 more source

De Novo Potent Peptide Nucleic Acid Antisense Oligomer Inhibitors Targeting SARS-CoV-2 RNA-Dependent RNA Polymerase via Structure-Guided Drug Design. [PDF]

Int J Mol Sci, 2023
Shehzadi K, Yu M, Liang J.
europepmc   +1 more source

The Sirt1‐Piezo1 Axis Promotes Bone Formation and Repair in Mice

Advanced Science, EarlyView.
Piezo1 upregulates in cartilage callus during bone repair, where its deletion impairs ossification and healing in mice, while activation enhances these processes. Sirt1 positively regulates Piezo1 expression and activity to promote osteogenesis and bone repair in mice.
Donghao Gan, Yi Ran, Hong Pan, Qinnan Yan, Wenjing Zhang, Bo Zhou, Pengzhi Xu, Rongdong Liao, Haipeng Xue, Will Jiang, Tailin He, Qingyun Jia, Lei Qin, Francis Y Lee, Di Chen, Chuanju Liu, Guozhi Xiao   +16 more
wiley   +1 more source

Shorter Peptide Nucleic Acid Probes Improve Affibody-Mediated Peptide Nucleic Acid-Based Pretargeting. [PDF]

ACS Pharmacol Transl Sci
Westerlund K, Oroujeni M, Gestin M, Clinton J, Hani Rosly A, Tano H, Vorobyeva A, Orlova A, Eriksson Karlström A, Tolmachev V.   +9 more
europepmc   +1 more source

Genital mycobacteriosis caused by Mycobacterium marinum detected in two captive sharks by peptide nucleic acid-fluorescence in situ hybridization. [PDF]

J Fish Dis, 2023
Inohana M, Komine T, Tanaka Y, Kurata O, Wada S.   +4 more
europepmc   +1 more source

Uric Acid Functions as an Endogenous Modulator of Microglial Function and Amyloid Clearance in Alzheimer's Disease

Advanced Science, EarlyView.
Higher serum UA levels are associated with reduced AD risk in epidemiological studies. UA enhances microglial phagocytic capacity primarily by restoring CD36 and TREM2 receptor recycling that is impaired by Aβ exposure. Therapeutically, UA supplementation improves cognitive function and reduces neuropathology in AD mouse model by enhancing microglial ...
De Xie, Qiuyang Zheng, Jiaming Lv, Qian Zhang, Zhiwei Cui, Shuai Huang, Wei Yu, Binyang Chen, Wanling Que, Shanpan Fu, Yuemei Xi, Jiayu Chen, Xueling Ye, Shuyi Chen, Hairong Zhao, Tetsuya Yamamoto, Hidenori Koyama, Xin Wang, Jidong Cheng   +18 more
wiley   +1 more source

Peptide nucleic acid (PNA) clamps reduce amplification of host chloroplast and mitochondria rRNA gene sequences and increase detected diversity in 16S rRNA gene profiling analysis of oak-associated microbiota. [PDF]

Environ Microbiome
Hussain U, Downie J, Ellison A, Denman S, McDonald J, McDonald J, Cambon MC.   +6 more
europepmc   +2 more sources