Results 91 to 100 of about 690,671 (364)

Machine Learning‐Enabled Polymer Discovery for Enhanced Pulmonary siRNA Delivery

Advanced Functional Materials, EarlyView.
This study provides an efficient approach to train a machine learning model by merging heterogeneous literature data to predict suitable polymers for siRNA delivery. Without the need for extensive laboratory synthesis, the machine learning enabled a virtual screening and successfully predicted a polymer that is validated for effective gene silencing in
Felix Sieber‐Schäfer, Min Jiang, Adrian Kromer, Anny Nguyen, Müge Molbay, Simone Pinto Carneiro, David Jürgens, Gerald Burgstaller, Bastian Popper, Benjamin Winkeljann, Olivia Monika Merkel   +10 more
wiley   +1 more source

Therapy of cancer by insect cells containing recombinant baculovirus encoding genes [PDF]

, 2002
Provided are compositions and methods of use for insect cells comprising baculovirus encoding non-surface expressed proteins and peptides. The claimed invention particularly relates to compositions comprising insect cells containing baculovirus that ...
Dhong, Zhongyun, Fidler, Isaiah J., Lu, Weixin   +2 more
core   +1 more source

Conformational analysis of Infectious bursal disease virus (IBDV) derived cell penetrating peptide (CPP) analogs

Veterinary World, 2013
Aim: This study was designed to develop peptide analogs of Infectious Bursal Disease (IBD) virus VP5 protein segment having cell penetrating ability to improve their interaction with cargo molecule (Nucleic acid) without affecting the backbone ...
Vinay G. Joshi, Arvind Kumar Singh, Kantaraja Chindera, Manish V. Bais, Ashok Kumar Tiwari, Satish Kumar   +5 more
doaj   +1 more source

Transducer Materials Mediated Deep Brain Stimulation in Neurological Disorders

Advanced Functional Materials, EarlyView.
This review discusses advanced transducer materials for improving deep brain stimulation (DBS) in neurological disorders. These materials respond to light, ultrasound, or magnetic fields, enabling precise, less invasive neuromodulation. Their stimulus‐responsive properties enhance neural control and adaptive therapy, paving the way for next‐generation ...
Di Zhao, Zhengyang Cao, Guangjun Zhong, Limin Shi, Junxia Xie, Jianhua Hao   +5 more
wiley   +1 more source

RNA interference approaches for treatment of HIV-1 infection. [PDF]

, 2015
HIV/AIDS is a chronic and debilitating disease that cannot be cured with current antiretroviral drugs. While combinatorial antiretroviral therapy (cART) can potently suppress HIV-1 replication and delay the onset of AIDS, viral mutagenesis often leads to
Bobbin, Maggie L, Burnett, John C, Rossi, John J   +2 more
core   +1 more source

Formulation of a Peptide Nucleic Acid Based Nucleic Acid Delivery Construct [PDF]

Bioconjugate Chemistry, 2010
Gene delivery biomaterials need to be designed to efficiently achieve nuclear delivery of plasmid DNA. Polycations have been used to package DNA and other nucleic acids within submicrometer-sized particles, offering protection from shear-induced or enzymatic degradation.
Peter G. Millili, Dan Yin, Millicent O. Sullivan, Haihong Fan, Ulhas P. Naik   +4 more
openaire   +3 more sources

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Schizosaccharomyces pombe Pol II transcription elongation factor ELL functions as part of a rudimentary super elongation complex [PDF]

, 2018
ELL family transcription factors activate the overall rate of RNA polymerase II (Pol II) transcription elongation by binding directly to Pol II and suppressing its tendency to pause.
Alonso-Nunez, Bahler, Bahler, Banks, Buchan, Cairns, Charles AS Banks, Chou, Christopher W Seidel, Coudreuse, Dana M Gibbon, Elmendorf, Florens, Garg, He, He, Joan W Conaway, Kim, Kimura, Kimura, Kitts, Kong, Langmead, Laurence A Florens, Li, Lin, Luo, Luo, Michael P Washburn, Miller, Monahan, Nimisha Sharma, Oliva, Preeti Dabas, Quinlan, Robinson, Ronald C Conaway, Rustici, Shilatifard, Shilatifard, Simone, Simone, Sneha Gopalan, Sobhian, Suarez, Szklarczyk, Tabb, Takahashi, Thorvaldsdottir, Tsai, Ward, Washburn, Ying Zhang, Yokoyama, Zhang   +54 more
core   +1 more source

Oligohistidine‐Functionalized Single‐Walled Carbon Nanotube‐Guided RNA Delivery to Improve Shoot Regeneration Efficiency in Plant Calli

Advanced Functional Materials, EarlyView.
The pH‐sensitive His6‐SWNTs, which is functionalized with oligohistidine, can deliver STTM396 molecules into callus cells. The STTM396–SWNT complex treatments enhance shoot regeneration efficiency by regulating the miR396‐GRF module in Arabidopsis and tomato calli.
Yeong Yeop Jeong, Hyuna Kwak, Woojin Jeong, Hongwoo Lee, Su‐Ji Jeon, Hyo‐Jun Lee, Pil Joon Seo, Seon‐Yeong Kwak   +7 more
wiley   +1 more source

The RCSB Protein Data Bank: views of structural biology for basic and applied research and education. [PDF]

, 2014
The RCSB Protein Data Bank (RCSB PDB, http://www.rcsb.org) provides access to 3D structures of biological macromolecules and is one of the leading resources in biology and biomedicine worldwide.
Berman, Helen M, Bi, Chunxiao, Bluhm, Wolfgang F, Bourne, Philip E, Burley, Stephen K, Christie, Cole H, Dutta, Shuchismita, Goodsell, David S, Green, Rachel Kramer, Prlić, Andreas, Rose, Peter W, Westbrook, John D, Woo, Jesse, Young, Jasmine, Zardecki, Christine   +14 more
core   +4 more sources