Results 91 to 100 of about 476,547 (316)

Cell-Penetrating Peptides—Mechanisms of Cellular Uptake and Generation of Delivery Systems

Pharmaceuticals, 2010
The successful clinical application of nucleic acid-based therapeutic strategies has been limited by the poor delivery efficiency achieved by existing vectors. The development of alternative delivery systems for improved biological activity is, therefore,
Sara Trabulo, Ana Luísa Cardoso, Miguel Mano, Maria C. Pedroso de Lima   +3 more
doaj   +1 more source

β‐1,3 Glucan Microparticles & Nanoparticles: Fabrication Methods & Applications in Immunomodulation & Targeted Drug Delivery

Advanced Healthcare Materials, EarlyView.
Beta‐glucans have gained significant attention as an immunomodulatory biomaterial with cell‐targeting capabilities. This review comprehensively outlines the design and fabrication methods for producing beta‐glucan particles at both the micro and nanoscale and their applications in immune cell targeting, immunomodulation, and drug delivery ...
Nate Dowdall, Todd Hoare
wiley   +1 more source

Special Issue: Molecular Properties and the Applications of Peptide Nucleic Acids

Molecules, 2018
Polyamide analogs of DNA, or peptide nucleic acid (PNA), were first proposed in 1991 by a group of chemists and biochemists in a memorable Science paper [1].[…]
Roberto Corradini
doaj   +1 more source

Synergistic Effects of Anti-CmeA and Anti-CmeB Peptide Nucleic Acids on Sensitizing Campylobacter jejuni to Antibiotics

Antimicrobial Agents and Chemotherapy, 2013
The CmeABC efflux pump in Campylobacter jejuni confers resistance to structurally divergent antimicrobials, and inhibition of CmeABC represents a promising strategy to control antibiotic-resistant Campylobacter.
Yang Mu, Zhangqi Shen, Byeonghwa Jeon, Lei Dai, Qijing Zhang   +4 more
semanticscholar   +1 more source

High‐Yield Bioproduction of Extracellular Vesicles from Stem Cell Spheroids via Millifluidic Vortex Transport

Advanced Materials, EarlyView.
Stem cell spheroids, produced via a high‐throughput microfabrication technique, are transported within a vortex generated at the outlet channels of a cross‐slot millifluidic chip. For Reynolds number exceeding 170–200, intermittent high shear stresses applied to each spheroid within the vortex trigger a massive release of biologically active ...
Elliot Thouvenot, Laura Charnay, Noa Burshtein, Jean‐Michel Guigner, Léonie Dec, Damarys Loew, Amanda K.A. Silva, Anke Lindner, Claire Wilhelm   +8 more
wiley   +1 more source

Synthetic molecular evolution of hybrid cell penetrating peptides

Nature Communications, 2018
Therapeutic peptide nucleic acids can be delivered into cells by conjugation to cell penetrating peptides (CPPs), but efficiency is usually low. Here the authors use synthetic molecular evolution and a luciferase-based library screen to generate new CPPs
W. Berkeley Kauffman, Shantanu Guha, William C. Wimley   +2 more
doaj   +1 more source

Cyclopentane-peptide nucleic acids for qualitative, quantitative, and repetitive detection of nucleic acids.

Analytical Chemistry, 2013
We report the development of chemically modified peptide nucleic acids (PNAs) as probes for qualitative and quantitative detection of DNA. The remarkable stability of PNAs toward enzymatic degradation makes this class of molecules ideal to develop as ...
Christopher M. Micklitsch, B. Y. Oquare, Chao Zhao, D. Appella   +3 more
semanticscholar   +1 more source

Functional Biomaterials Derived from Protein Liquid–Liquid Phase Separation and Liquid‐to‐Solid Transition

Advanced Materials, EarlyView.
Protein can undergo liquid–liquid phase separation and liquid‐to‐solid transition to form liquid condensates and solid aggregates. These phase transitions can be influenced by post‐translational modifications, mutations, and various environmental factors.
Tianchen Li, Dea Ilhamsyah, Benedict Tai, Yi Shen   +3 more
wiley   +1 more source

Investigation of synthesis of cytosine-containing monomer for negatively charged peptide nucleic acids.

Тонкие химические технологии, 2007
A cytosine-containing monomer for negatively charged peptide nucleic acids has been prepared for the first time, and the ways of its synthesis have been optimized.
A. V. Baranov, N. S. Tsvid, V. I. Lukyanchenko, D. I. Prokhorov, Yu. G. Kirillova, V. I. Shvets   +5 more
doaj  

Complexation of fungal extracellular nucleic acids by host LL-37 peptide shapes neutrophil response to Candida albicans biofilm

Frontiers in Immunology
Candida albicans remains the predominant cause of fungal infections, where adhered microbial cells form biofilms - densely packed communities. The central feature of C.
Magdalena Juszczak, Magdalena Juszczak, Marcin Zawrotniak, Maria Rapala-Kozik   +3 more
doaj   +1 more source