Results 111 to 120 of about 725,272 (355)

Complexation of fungal extracellular nucleic acids by host LL-37 peptide shapes neutrophil response to Candida albicans biofilm

Frontiers in Immunology
Candida albicans remains the predominant cause of fungal infections, where adhered microbial cells form biofilms - densely packed communities. The central feature of C.
Magdalena Juszczak, Magdalena Juszczak, Marcin Zawrotniak, Maria Rapala-Kozik   +3 more
doaj   +1 more source

Fluorogenic PNA probes

Beilstein Journal of Organic Chemistry, 2018
Fluorogenic oligonucleotide probes that can produce a change in fluorescence signal upon binding to specific biomolecular targets, including nucleic acids as well as non-nucleic acid targets, such as proteins and small molecules, have applications in ...
Tirayut Vilaivan
doaj   +1 more source

The RCSB Protein Data Bank: views of structural biology for basic and applied research and education. [PDF]

, 2014
The RCSB Protein Data Bank (RCSB PDB, http://www.rcsb.org) provides access to 3D structures of biological macromolecules and is one of the leading resources in biology and biomedicine worldwide.
Berman, Helen M, Bi, Chunxiao, Bluhm, Wolfgang F, Bourne, Philip E, Burley, Stephen K, Christie, Cole H, Dutta, Shuchismita, Goodsell, David S, Green, Rachel Kramer, Prlić, Andreas, Rose, Peter W, Westbrook, John D, Woo, Jesse, Young, Jasmine, Zardecki, Christine   +14 more
core   +4 more sources

Strategies to Improve the Lipophilicity of Hydrophilic Macromolecular Drugs

Advanced Healthcare Materials, EarlyView.
Hydrophilic macromolecular drugs can be successfully lipidized by covalent attachment of lipids, by hydrophobic ion pairing with negatively or positively charged surfactants, and by dry or wet reverse micelle formation. Lipophilicity enhancement of hydrophilic macromolecules has several benefits including stability and bioavailability improvement ...
Sera Lindner, Stefan Keim, Soheil Haddadzadegan, Odile Fernandez Romero, Katrin Zöller, Gabriel Stern, Ilaria Cesi, Krum Kafedjiiski, Andreas Bernkop‐Schnürch   +8 more
wiley   +1 more source

Investigation of synthesis of cytosine-containing monomer for negatively charged peptide nucleic acids.

Тонкие химические технологии, 2007
A cytosine-containing monomer for negatively charged peptide nucleic acids has been prepared for the first time, and the ways of its synthesis have been optimized.
A. V. Baranov, N. S. Tsvid, V. I. Lukyanchenko, D. I. Prokhorov, Yu. G. Kirillova, V. I. Shvets   +5 more
doaj  

Synthetic molecular evolution of hybrid cell penetrating peptides

Nature Communications, 2018
Therapeutic peptide nucleic acids can be delivered into cells by conjugation to cell penetrating peptides (CPPs), but efficiency is usually low. Here the authors use synthetic molecular evolution and a luciferase-based library screen to generate new CPPs
W. Berkeley Kauffman, Shantanu Guha, William C. Wimley   +2 more
doaj   +1 more source

Identification of the prebiotic translation apparatus within the contemporary ribosome [PDF]

, 2009
A structural element that could have existed independently in the prebiotic era was identified at the active site of the contemporary ribosome. It is suggested to have functioned as a proto-ribosome catalyzing peptide bond formation and non-coded ...
Ada Yonath, Anat Bashan, Chen Davidovich, Ilana Agmon   +3 more
core   +1 more source

Redefining Therapies for Drug‐Resistant Tuberculosis: Synergistic Effects of Antimicrobial Peptides, Nanotechnology, and Computational Design

Advanced Healthcare Materials, EarlyView.
Antimicrobial peptide (AMP)‐loaded nanocarriers provide a multifunctional strategy to combat drug‐resistant Mycobacterium tuberculosis. By enhancing intracellular delivery, bypassing efflux pumps, and disrupting bacterial membranes, this platform restores phagolysosome fusion and macrophage function.
Christian S. Carnero Canales, Jessica Ingrid Marquez Cazorla, Renzo Marianito Marquez Cazorla, Aline Martins dos Santos, Jonatas Lobato Duarte, Letícia Oliveira Catarin Nunes, Túlio Custódio Reis, Lara Cerazi Salvador, Norival Alves Santos‐Filho, Rafael Miguel Sábio, Hélder A. Santos, Fernando Rogério Pavan   +11 more
wiley   +1 more source

Peptide nucleic acid–dependent artifact can lead to false-positive triplex gene editing signals

, 2021
Pui Yan Ho, Zhen Zhang, Mark Hayes, Andrew Curd, Carla Dib, Maire Rayburn, Sze Nok Tam, Tumul Srivastava, Brandon Hriniak, Xiaojun Li, Scott F. Leonard, Lan Wang, Somayeh S. Tarighat, Derek Sim, Mark J. Fiandaca, James Coull, Allen Ebens, Marshall Fordyce, Agnieszka Czechowicz   +18 more
openalex   +2 more sources

Delivery of Multifunctional Microspheres via Intravesical Instillation for Bladder Carcinoma: Therapeutic Potential and Mechanistic Insights

Advanced Healthcare Materials, EarlyView.
PCTM microspheres were successfully synthesized using microfluidic and click chemistry techniques.In Vivo and in vitro experiments have shown that PCTM microspheres have obvious targeting, adhesion, membrane penetration and anti‐tumor properties for bladder tumors.The antitumor mechanism of PCTM microspheres is to indirectly induce S‐stage blockage of ...
Zhaoxiang Lu, Wentie Yang, Youzhi Hong, Yusen Qiao, Chaozhao Liang   +4 more
wiley   +1 more source