Results 111 to 120 of about 677,914 (356)

Protected maleimide building blocks for the decoration of peptides, peptoids, and peptide nucleic acids.

Bioconjugate chemistry, 2013
Monomers allowing for the introduction of [2,5-dimethylfuran]-protected maleimides into polyamides such as peptides, peptide nucleic acids, and peptoids were prepared, as well as the corresponding oligomers.
Xavier Elduque, Albert Sánchez, K. Sharma, E. Pedroso, A. Grandas   +4 more
semanticscholar   +1 more source

Nanomaterial‐Enhanced Biosensing: Mechanisms and Emerging Applications

Advanced Healthcare Materials, EarlyView.
Nanomaterial integration transforms biosensor capabilities through enhanced signal transduction, sensitivity, and selectivity. This review analyzes how nanoscale materials—from nanoparticles to nanosheets—leverage unique physicochemical properties to revolutionize electrochemical, optical, and electrical biosensing.
Younghak Cho, Yunyoung Choi, Yerim Jang, Hyejeong Seong   +3 more
wiley   +1 more source

Special Issue: Molecular Properties and the Applications of Peptide Nucleic Acids

Molecules, 2018
Polyamide analogs of DNA, or peptide nucleic acid (PNA), were first proposed in 1991 by a group of chemists and biochemists in a memorable Science paper [1].[…]
Roberto Corradini
doaj   +1 more source

Aptamer-based therapeutics and their potential in radiopharmaceutical design [PDF]

, 2007
Aptamers, short, single stranded oligonucleotide entities, have been developed in the past 15 years against a plethora of targets and for a variety of applications.
Ferreira, Catia S. M., Missailidis, Sotiris   +1 more
core   +3 more sources

Membrane Fusion‐Inspired Nanomaterials: Emerging Strategies for Infectious Disease and Cancer Diagnostics

Advanced Healthcare Materials, EarlyView.
Membrane fusion‐inspired nanomaterials offer transformative potential in diagnostics by mimicking natural fusion processes to achieve highly sensitive and specific detection of disease biomarkers. This review highlights recent advancements in nanomaterial functionalization strategies, signal amplification systems, and stimuli‐responsive fusion designs,
Sojeong Lee, Khulan Nyamzaya, Jueun Han, Yejin Song, Jihee Lee, Jung Hyun Jo, Seungmin Bang, Eun‐Kyung Lim, Seungjoo Haam, Eunjung Kim   +9 more
wiley   +1 more source

Synthetic molecular evolution of hybrid cell penetrating peptides

Nature Communications, 2018
Therapeutic peptide nucleic acids can be delivered into cells by conjugation to cell penetrating peptides (CPPs), but efficiency is usually low. Here the authors use synthetic molecular evolution and a luciferase-based library screen to generate new CPPs
W. Berkeley Kauffman, Shantanu Guha, William C. Wimley   +2 more
doaj   +1 more source

Design and Validation of Hybrid Polymer‐Lipid Nanoparticles as Novel Transfection Vectors for MicroRNA Delivery to Human Cardiac Fibroblasts

Advanced Healthcare Materials, EarlyView.
Hybrid NPs are developed as efficient, scalable nanocarriers for in vitro microRNA delivery, ensuring high loading efficiency, controlled release, physiological and long‐term storage stability. They outperform commercial lipid‐based reagents in terms of transfection efficiency and biocompatibility.
Letizia Nicoletti, Camilla Paoletti, Martina Coletto, Elena Marcello, Giovanni Paolo Stola, Francesca Cossetta, Francesco Schiavone, Ilaria Andreana, Barbara Stella, Silvia Arpicco, Clara Mattu, Valeria Chiono   +11 more
wiley   +1 more source

Investigation of synthesis of cytosine-containing monomer for negatively charged peptide nucleic acids.

Тонкие химические технологии, 2007
A cytosine-containing monomer for negatively charged peptide nucleic acids has been prepared for the first time, and the ways of its synthesis have been optimized.
A. V. Baranov, N. S. Tsvid, V. I. Lukyanchenko, D. I. Prokhorov, Yu. G. Kirillova, V. I. Shvets   +5 more
doaj  

Complexation of fungal extracellular nucleic acids by host LL-37 peptide shapes neutrophil response to Candida albicans biofilm

Frontiers in Immunology
Candida albicans remains the predominant cause of fungal infections, where adhered microbial cells form biofilms - densely packed communities. The central feature of C.
Magdalena Juszczak, Magdalena Juszczak, Marcin Zawrotniak, Maria Rapala-Kozik   +3 more
doaj   +1 more source

Reprogramming the assembly of unmodified DNA with a small molecule [PDF]

, 2016
The ability of DNA to store and encode information arises from base pairing of the four-letter nucleobase code to form a double helix. Expanding this DNA ‘alphabet’ by synthetic incorporation of new bases can introduce new functionalities and enable the ...
A Chworos, A Rich, AK Ogawa, AM Pyle, Andrea A. Greschner, Anne Petitjean, B Roy, BJ Cafferty, C Geary, C Hao, Christopher J. Serpell, D Jiang, D Shin, DA Malyshev, DC Di Giammartino, E Largy, E Meggers, FA Aldaye, Faisal Aldaye, GM Whitesides, H Chen, H Yang, Hanadi F. Sleiman, HZ Yang, J Choi, JA Piccirilli, JA Zerkowski, JC Chaput, JD Watson, KS Park, L Weill, M Egholm, M Egholm, M Kimoto, M Ma, M Martin-Ortiz, M Polak, M Shionoya, M Winnacker, M-Y Pan, MC Chen, N Berova, N Safaee, Nicole Avakyan, OP Çetinkol, RJ Davies, RJ Davies, S Balasubramanian, S Chakraborty, S Woo, SS Jain, TF De Greef, Violeta Toader, Y Krishnan, Y Zeng, YN Teo, YQ Wu, Z Yang, Ö Persil   +58 more
core   +1 more source