Results 141 to 150 of about 665,888 (285)

Extension of the PNA world by functionalized PNA monomers eligible candidates for inverse Diels Alder Click Chemistry

open access: yesInternational Journal of Medical Sciences, 2010
Progress in genome research led to new perspectives in diagnostic applications and to new promising therapies. On account of their specificity and sensitivity, nucleic acids (DNA/RNA) increasingly are in the focus of the scientific interest.
Manfred Wiessler, Waldemar Waldeck, Ruediger Pipkorn, Christian Kliem, Peter Lorenz, Heinz Fleischhacker, Manuel Hafner, Klaus Braun
doaj  

Inhibition of telomerase activity by a cell‐penetrating peptide nucleic acid construct in human melanoma cells [PDF]

open access: bronze, 2000
Raffaella Villa   +5 more
openalex   +1 more source

Enhanced Sampling Algorithms [PDF]

open access: yesarXiv, 2010
In biomolecular systems (especially all-atom models) with many degrees of freedom such as proteins and nucleic acids, there exist an astronomically large number of local-minimum-energy states. Conventional simulations in the canonical ensemble are of little use, because they tend to get trapped in states of these energy local minima.
arxiv  

Applications of Enhanced Sampling Methods to Biomolecular Self-Assembly: A Review [PDF]

open access: yesarXiv
This review article discusses some common enhanced sampling methods in relation to the process of self-assembly of biomolecules. An introduction to self-assembly and its challenges is covered followed by a brief overview of the methods and analysis for replica-exchange molecular dynamics, umbrella sampling, metadynamics, and machine learning based ...
arxiv  

Peptide Nucleic Acids: Methods and Protocols

open access: yesMethods in Molecular Biology, 2020
P. Nielsen
semanticscholar   +1 more source

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