Results 141 to 150 of about 340,837 (195)

Peptide-Templated Nucleic Acid Ligation

Journal of Molecular Evolution, 2003
Short oligonucleotide and peptide replicators have been described. To determine whether cross-replication could have occurred between such systems, we have attempted to show that peptides can specifically template the ligation of nucleic acids. A complex between a 35-mer anti-Rev RNA aptamer and a 17-mer arginine-rich motif (ARM) peptide from the HIV-1
Matthew, Levy, Andrew D, Ellington
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Hybridization of Peptide Nucleic Acid

Biochemistry, 1998
The thermodynamics of hybridization and the conformations of decameric mixed purine-pyrimidine sequence PNA/PNA, PNA/DNA, and DNA/DNA duplexes have been studied using fluorescence energy transfer (FET), absorption hypochromicity (ABS), isothermal titration calorimetry (ITC), and circular dichroism (CD) techniques.
Ratilainen, T., Holmén, A., Tuite, E., Haaima, G., Christensen, L., Nielsen, Peter Eigil, Nordén, B.   +6 more
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Nucleobase Modified Peptide Nucleic Acid

Nucleosides, Nucleotides and Nucleic Acids, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
R H E, Hudson, R D, Viirre, N, McCourt, J, Tse   +3 more
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Pretargeting using peptide nucleic acid

Cancer, 1997
Pretargeting studies in animals and humans have usually involved (strept)avidin and biotin. Depending on the particular strategy, endogenous biotin can adversely influence localization when these molecules are used.As an alternative to (strept)avidin and biotin, we have explored the use of a single-stranded peptide nucleic acid (PNA) bound to a protein
M, Rusckowski, T, Qu, F, Chang, D J, Hnatowich   +3 more
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Facile synthesis of peptide nucleic acids and peptide nucleic acid‐peptide conjugates on an automated peptide synthesizer

Journal of Peptide Science, 2010
AbstractPeptide nucleic acids (PNAs) are DNA mimics with a neutral peptide backbone instead of the negatively charged sugar phosphates. PNAs exhibit several attractive features such as high chemical and thermal stability, resistance to enzymatic degradation, and stable binding to their RNA or DNA targets in a sequence‐specific manner.
Joshi, R., Jha, D., Su, W., Engelmann, J.   +3 more
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Peptide Nucleic Acids [PDF]

, 1998
A novel class of compounds, known as peptide nucleic acids, bind complementary ssDNA and RNA strands more strongly than a corresponding DNA. The peptide nucleic acids generally comprise ligands such as naturally occurring DNA bases attached to a peptide backbone through a suitable linker.
Buchardt, Ole, Engholm, Michael, Nielsen, Peter E., Berg, Rolf Henrik   +3 more
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Synthesis of Peptide Nucleic Acid–Peptide Conjugates

2004
Synthetic oligonucleotides are versatile tools for recognizing ribonucleic acid and deoxyribonucleic acid. This chapter describes methods for enhancing recognition by derivatizing oligonucleotides with either proteins or peptides.
Kunihiro, Kaihatsu, David R, Corey
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Applications of peptide nucleic acids

Current Opinion in Biotechnology, 1999
Several exciting new developments in the applications of the DNA mimic peptide nucleic acid (PNA) have been published recently. A possible breakthrough may have come in efforts to develop PNA into gene therapeutic drugs. In eukaryotic systems, antisense activity of PNAs (as peptide conjugates) has been reported in nerve cells and even in rats upon ...
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Peptide Nucleic Acids

2010
PNA, antisense, antigene ...
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Peptide Nucleic Acids (PNAs)

ChemInform, 2007
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Shabih Shakeel, Sajjad Karim, Arif Ali
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