Results 191 to 200 of about 611,085 (327)

Interpretability and Representability of Commutative Algebra, Algebraic Topology, and Topological Spectral Theory for Real‐World Data

Advanced Intelligent Discovery, EarlyView.
This article investigates how persistent homology, persistent Laplacians, and persistent commutative algebra reveal complementary geometric, topological, and algebraic invariants or signatures of real‐world data. By analyzing shapes, synthetic complexes, fullerenes, and biomolecules, the article shows how these mathematical frameworks enhance ...
Yiming Ren, Guo‐Wei Wei
wiley   +1 more source

5-Triazolyl uracil improves nucleobase stacking, pyrimidine recognition, biological activity, and specificity of RNA-binding triplex-forming peptide nucleic acids. [PDF]

Nucleic Acids Res
Saei SF, Endoh T, Baskevics V, Kumpina I, Katkevics M, Sugimoto N, Rozners E.   +6 more
europepmc   +1 more source

Cationic Calix[4]arene Vectors to Efficiently Deliver AntimiRNA Peptide Nucleic Acids (PNAs) and miRNA Mimics. [PDF]

Pharmaceutics, 2023
Gasparello J, Papi C, Zurlo M, Volpi S, Gambari R, Corradini R, Casnati A, Sansone F, Finotti A.   +8 more
europepmc   +1 more source

Interspecies Biofilm Dynamics Among Staphylococci: Inflammatory Contributions to Chronic Rhinosinusitis

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Introduction Staphylococcus species are frequently isolated from the sinonasal niche of chronic rhinosinusitis (CRS) patients. While Staphylococcus aureus is often associated with recalcitrant CRS, Staphylococcus epidermidis and Staphylococcus lugdunensis are largely deemed commensal.
Sintayehu Ambachew, Mahnaz Ramezanpour, Clare M. Cooksley, Sholeh Feizi, Muhammed Awad, Kevin Aaron Fenix, Peter‐John Wormald, Alkis J. Psaltis, Sarah Vreugde   +8 more
wiley   +1 more source

Peptide nucleic acids in parallel orientation form invasion complexes with double-stranded DNA. [PDF]

RSC Chem Biol
Shibata M, Sugimoto H, Hibino M, Shoji O, Aiba Y.   +4 more
europepmc   +1 more source

Multivalent Lactobionic Acid and N-Acetylgalactosamine-Conjugated Peptide Nucleic Acids for Efficient In Vivo Targeting of Hepatocytes. [PDF]

Adv Healthc Mater, 2023
Kumar V, Wahane A, Gupta A, Manautou JE, Bahal R.   +4 more
europepmc   +1 more source

Exosome‐mediated gut–brain axis signaling in neurodegenerative diseases: Mechanisms, experimental evidence, and therapeutic perspectives—A narrative review

Animal Models and Experimental Medicine, EarlyView.
The gut–brain axis is a bidirectional communication network between the intestines and brain, mediated by gut microbiota and exosomes, that regulates neuroinflammation, protein aggregation, and neuronal health processes central to neurodegenerative diseases.
Waheeb Sami Aggad, Rakesh Ghosh, Hailah M. Almohaimeed, Zuhair M. Mohammedsaleh, Fayez M. Saleh, Amany I. Almars, S. Renuka Jyothi, Rajashree Panigrahi, Ajoy Kumer, Bikram Dhara   +9 more
wiley   +1 more source

Secondary Site Ligand for Integrin αVβ3 Enables Targeted mRNA Delivery

Angewandte Chemie, EarlyView.
Non‐orthosteric, low‐affinity ligands for integrin αVβ3, identified by fragment screening, achieve superselective nanoparticle targeting (ακ ≈ 3) of αVβ3‐overexpressing endothelial cells. Unlike traditional arginine–glycine–aspartate decorated particles, these fragment‐functionalized LNPs discriminate cells by receptor density and deliver mRNA to ...
Sebastian Bayer, María García‐García, Raffaele Senatore, Maria Stratoudaki, Alina Markhof, Angelika Berger‐Becvar, Anna Sophia Parianou, Christoph Rademacher   +7 more
wiley   +2 more sources

<i>γ</i>-Amino Carboxylic Acid Modification Enhances the Efficacy of Peptide Nucleic Acids Targeting miR-221-3p in Lung Cancer Cell Lines. [PDF]

Curr Issues Mol Biol
Yoon Y, Joo NR, Kim T, Bae D, Lee S, Pak S, Min J, Park J, Choi Y.   +8 more
europepmc   +1 more source

Therapeutic Applications of Stimuli‐Based Release and Engineering of Extracellular Vesicles

Advanced NanoBiomed Research, EarlyView.
This review summarizes the effects of endogenous and exogenous stimuli, their effects on the natural release of extracellular vesicles, as well as their uptake and release. It also gives an overview of stimuli‐responsive EVs and their therapeutic applications. Extracellular vesicles (EVs), nano‐ to microsized lipid bilayer membrane‐bound particles, are
Gloria Kemunto, Kristen Dellinger
wiley   +1 more source