Results 201 to 210 of about 611,085 (327)

Nonviral Gold Nanoparticle‐Mediated Delivery of CRISPR‐Cas9 Ribonucleoprotein and Long DNA Transgenes Into Primary Blood Cells

Advanced NanoBiomed Research, EarlyView.
CRISPR/Cas9 has revolutionized the field of gene therapy, but delivery remains an outstanding issue. We propose a nonviral gold‐nanoparticle platform for co‐delivery of CRISPR/Cas9 ribonucleoprotein and long 2.1 kilobase dsDNA transgene constructs. This CRISPR‐AuNP is inexpensive to produce and mediate gene editing and DNA delivery in T cells and CD34+
Rachel A. Cunningham, Karthikeya S. V. Gottimukkala, Daniel D. Lane, Katrina Poljakov, Patricia Lipson, Mark R. Enstrom, Alessandro Rizzi, Aude G. Chapuis, Jennifer E. Adair   +8 more
wiley   +1 more source

Antispacer peptide nucleic acids for sequence-specific CRISPR-Cas9 modulation. [PDF]

Nucleic Acids Res, 2022
Economos NG, Quijano E, Carufe KEW, Perera JDR, Glazer PM.   +4 more
europepmc   +1 more source

Discovery of a Reversible Sub‐Picomolar Thrombin Inhibitor Using DCC

Angewandte Chemie, EarlyView.
An ultrapotent yet fully reversible trivalent thrombin inhibitor discovered through screening a large dynamic combinatorial library (DCL) of 125 000 members of self‐assembled fragments. The innovative approach leverages size‐exclusion‐based affinity selection, coupled with MALDI‐TOF mass spectrometry readout, enabling the full workflow to be completed ...
Millicent Dockerill, Richard J. Payne, Nicolas Winssinger   +2 more
wiley   +2 more sources

Investigating the Interactions of Peptide Nucleic Acids with Multicomponent Peptide Hydrogels for the Advancement of Healthcare Technologies. [PDF]

Gels
Giordano S, Terracciano M, Gallo E, Diaferia C, Falanga AP, Accardo A, Franzese M, Salvatore M, Piccialli G, Borbone N, Oliviero G.   +10 more
europepmc   +1 more source

Peptide Nucleic Acids Containing Cationic/Amino-Alkyl Modified Bases Promote Enhanced Hybridization Kinetics and Thermodynamics with Single-Strand DNA. [PDF]

ACS Omega, 2023
Podlaski F, Cornwell S, Wong K, McKittrick B, Kim JH, Jung D, Jeon Y, Jung KB, Tolias P, Windsor WT.   +9 more
europepmc   +1 more source

Incorporation of Naked Peptide Nucleic Acids into Liposomes Leads to Fast and Efficient Delivery.

Bioconjugate chemistry, 2015
Concetta Avitabile, A. Accardo, Paola Ringhieri, G. Morelli, M. Saviano, G. Montagner, E. Fabbri, E. Gallerani, R. Gambari, A. Romanelli   +9 more
semanticscholar   +1 more source

Rewriting Tumor Immunity With Bacterial Membrane Vesicles: A Versatile and Potent Therapeutic Strategy

Advanced NanoBiomed Research, EarlyView.
Bacterial membrane vesicles (BMVs) emerge as promising platforms for cancer immunotherapy owing to their intrinsic adjuvant properties and tunable cargo delivery capabilities. Their ability to modulate the tumor microenvironment, enhance antitumor immune responses, and support personalized therapeutic strategies highlights their growing potential as ...
Md Sifat Rahi, Md Mijanur Rahman, Asma Talukder, Urooj Yousaf Virk, Jennifer C. Wilson, Nigel McMillan, Ming Q. Wei   +6 more
wiley   +1 more source

Broad Host Range Peptide Nucleic Acids Prevent Gram-Negative Biofilms Implicated in Catheter-Associated Urinary Tract Infections. [PDF]

Microorganisms
Karp HQ, Nowak ES, Kropp GA, Col NA, Schulz MD, Sriranganathan N, Rao J.   +6 more
europepmc   +1 more source

Fluorobenzene Nucleobase Analogues for Triplex-Forming Peptide Nucleic Acids. [PDF]

Chembiochem, 2022
Kumar V, Rozners E.
europepmc   +1 more source

Studies of new molecular systems based on nucleic acids and their analogues for biotechnological applications [PDF]

, 2008
Moccia, Maria
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