Results 251 to 260 of about 725,272 (355)

Nanoparticle Immunoadjuvant Complexes Augment Germinal Center Responses to Vaccination

Advanced Science, EarlyView.
Scaffolding IL‐21 on the surface of a self‐assembling nanoparticle immunogen drives improved germinal center and humoral immune responses. These nanoparticle immunoadjuvant complexes (NICs) functionally modulate the germinal center driving improved somatic hypermutation and antibody maturation, suggesting this platform has potential utility as a ...
Nicholas J. Tursi, Colby J. Agostino, Jinwei Huang, Toshitha Kannan, Niklas Laenger, Jennifer Londregan, Katlyn Lederer, Michaela Helble, Nicole Bedanova, Cory Livingston, Ebony N. Gary, Madison McCanna, Marta Tarquis Medina, Rumi Habib, Ignacio Rodriguez Relaño, Ivan Maillard, Ami Patel, David Allman, Andrew Kossenkov, Amelia Escolano, Daniel W. Kulp, David. B. Weiner   +21 more
wiley   +1 more source

Papain-Mediated Conjugation of Peptide Nucleic Acids to Delivery Peptides: A Density Functional Theory/Molecular Mechanics Metadynamics Study in Aqueous and Organic Solvent. [PDF]

J Phys Chem B
González RD, Carvalho ATP.
europepmc   +1 more source

Detection and identification of lactic acid bacteria in milk and industrial starter culture with fluorescently labeled rRNA-targeted peptide nucleic acid probes [PDF]

, 2001
Oriane Matte-Tailliez, Pascal Quénée, Recep Çıbık, Jacques van Opstal, Fabrice Dessevre, Olivier Firmesse, Patrick Tailliez   +6 more
openalex   +1 more source

Antitumor effects of EGFR antisense guanidine-based peptide nucleic acids in cancer models.

ACS Chemical Biology, 2013
S. Thomas, Bichismita Sahu, Srinivas Rapireddy, R. Bahal, S. Wheeler, Eva M Procopio, Joseph Kim, S. Joyce, S. Contrucci, Yun Wang, Simion I. Chiosea, K. Lathrop, Simon C Watkins, J. Grandis, B. Armitage, Danith H. Ly   +15 more
semanticscholar   +1 more source

MARPLE: A Proximity‐Triggered CRISPR‐Cas13 Platform for Ultrasensitive Antibody Detection

Advanced Science, EarlyView.
MARPLE is a modular CRISPR‐Cas13 immunoassay that uses antibody‐induced proximity to trigger a toehold‐exchange reaction, releasing an RNA activator for Cas13. This one‐pot, isothermal architecture enables ultrasensitive (femtomolar) and highly specific detection of diverse antibodies, including therapeutic, pathogen‐specific, and cancer‐associated ...
Elena Spezzani, Luca Capelli, Denise Di Lena, Alejandro Chamorro‐Garcia, Rudy Ippodrino, Alessandro Porchetta, Alessandro Bertucci   +6 more
wiley   +1 more source

Triplex-forming peptide nucleic acids as emerging ligands to modulate structure and function of complex RNAs. [PDF]

Chem Commun (Camb)
Katkevics M, MacKay JA, Rozners E.
europepmc   +1 more source

Perfluoroalkylchain conjugation as a new tactic for enhancing cell permeability of peptide nucleic acids (PNAs) via reducing the nanoparticle size

, 2015
Satheesh Ellipilli, Raghavendra Vasudeva Murthy, Krishna N. Ganesh   +2 more
openalex   +2 more sources

Serology in the Digital Age: Using Long Synthetic Peptides Created from Nucleic Acid Sequences as Antigens in Microarrays [PDF]

, 2016
Muhammad Rizwan, Bengt Rönnberg, Maksims Čistjakovs, Åke Lundkvist, Rüdiger Pipkorn, Jonas Blomberg   +5 more
openalex   +1 more source

Protected maleimide building blocks for the decoration of peptides, peptoids, and peptide nucleic acids.

Bioconjugate chemistry, 2013
Xavier Elduque, Albert Sánchez, K. Sharma, E. Pedroso, A. Grandas   +4 more
semanticscholar   +1 more source

A Modular DNAzyme for Precise Visualization and Intervention of Alternative Splicing Isoforms in Live Cells

Advanced Science, EarlyView.
A Stringent dUPlex‐activated Error Robust (SUPER) DNAzyme system enables real‐time imaging of alternative mRNA splicing (e.g., Bcl‐xL/Bcl‐xS) in living cells via target‐triggered split‐DNAzyme reassembly and dual‐color fluorescence. It also achieves mRNA‐selective knockdown through DNAzyme‐based gene regulation, serving as a versatile tool for splicing
Mengru Lin, Jiale Sun, Yuqing Mao, Yuhao Tang, Fuan Wang, Zhihong Liu, Jing Wang   +6 more
wiley   +1 more source