Results 271 to 280 of about 719,118 (354)

Nanomedicines Against Mitochondrial Dysfunction‐Induced Metabolic Diseases

Advanced Science, EarlyView.
Mitochondrial dysfunction is central to metabolic diseases. Nanomedicine offers transformative approaches for restoring function via targeted delivery, responsive release, and multimodal therapy. This review outlines the pathological basis, nanocarrier design, organelle‐specific targeting, recent advances, and future clinical translation challenges ...
Ke Xu, Leyi Wang, Tao Lv, Chen Jin, Qiong Wu, Yongjie Zhou, Gang Xu, Zhenyu Duan, Kui Luo, Jiayin Yang   +9 more
wiley   +1 more source

Endosomolytic peptides enable the cellular delivery of peptide nucleic acids.

Chem Commun (Camb)
Giancola JB, Raines RT.
europepmc   +1 more source

Peptide nucleic acids (PNAs) control function of SARS-CoV-2 frameshifting stimulatory element trough PNA-RNA-PNA triplex formation. [PDF]

Heliyon
Rahman MM, Ryan CA, Tessier BR, Rozners E.   +3 more
europepmc   +1 more source

Complexation to Cationic Microspheres of Double-Stranded Peptide Nucleic Acid-DNA Chimeras Exhibiting Decoy Activity

, 2004
Carlo Mischiati, Alessia Sereni, Alessia Finotti, Laura Breda, Rita Cortesi, Claudio Nastruzzi, Alessandra Romanelli, Michele Saviano, Nicoletta Bianchi, Carlo Pedone, Monica Borgatti, Roberto Gambari   +11 more
openalex   +2 more sources

Cyclopentane-peptide nucleic acids for qualitative, quantitative, and repetitive detection of nucleic acids.

Analytical Chemistry, 2013
Christopher M. Micklitsch, B. Y. Oquare, Chao Zhao, D. Appella   +3 more
semanticscholar   +1 more source

Targeting G3BP1 Condensate Topology Promotes Stress Granule Assembly via m6A‐IGF2BP1 for Ischemic Stroke Rescue

Advanced Science, EarlyView.
Our research reveals that small‐molecule icariin (ICA) directly binds Ras‐GTPase‐activating protein SH3 domain‐binding protein 1 (G3BP1), inducing conformational change and oligomerization. This interaction confers neuroprotection by recruiting insulin‐like growth factor 2 mRNA‐binding protein 1 (IGF2BP1) and modulating N6‐methyladenosine (m6A ...
Ling Li, Yong‐Dong Guo, Xiao‐Wen Zhang, Zhi‐Yong Du, Yu‐Qi Wang, Zhuo Yang, Qian‐Wei Luo, Fang‐Fang Zhuo, Tian‐Tian Wei, Zheng‐Ping Liu, Bo Han, Wei Yu, Pei‐Pei Zhang, Wei Zhou, Zhi‐Yuan Lu, Peng‐Fei Tu, Chun‐Hong Zheng, Ke‐Wu Zeng   +17 more
wiley   +1 more source

Harnessing Peptide Nucleic Acids and the Eukaryotic Resolvase MOC1 for Programmable, Precise Generation of Double-Strand DNA Breaks. [PDF]

Anal Chem
Sivakrishna Rao G, Saleh AH, Melliti F, Muntjeeb S, Mahfouz M.   +4 more
europepmc   +1 more source

Peptide Nucleic Acid Fluorescence In Situ Hybridization-Based Identification of Candida albicans and Its Impact on Mortality and Antifungal Therapy Costs

, 2006
Graeme N. Forrest, K. Mankes, Mary Ann Jabra‐Rizk, Elizabeth Weekes, J. Kristie Johnson, Durry P. Lincalis, Richard A. Venezia   +6 more
openalex   +1 more source

Evolution of Multivalent Aptamer Corona for High‐Throughput Multiplexed Detection of Multiple Cancers

Advanced Science, EarlyView.
A multivalent aptamer corona is evolved via established ProteoFish‐SELEX (systematic evolution of ligands by exponential enrichment) for high‐throughput multiplexed detection of multiple cancers. Clinical validation using multivalent aptamer corona demonstrated high accuracy and specificity in multiplexed detection of ovarian, lung, and colorectal ...
Mengjie Wang, Baichuan Jin, Xin Dai, Haozhe Huang, Qiqi Liu, Jianqing Zhu, Haixing Ju, Qixun Chen, Yongmei Song, Weihong Tan, Yuan Liu   +10 more
wiley   +1 more source

Triplex-Forming Peptide Nucleic Acids with Extended Backbones. [PDF]

Chembiochem, 2020
Kumar V, Brodyagin N, Rozners E.
europepmc   +1 more source