Results 301 to 310 of about 1,200,908 (357)
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Formyl-peptide receptors revisited
Trends in Immunology, 2002Leukocytes accumulate at sites of inflammation and microbial infection in direct response to locally produced chemotactic factors, which signal through specific G protein-coupled receptors. The first chemotactic factors to be structurally defined were the N-formyl peptides. Unlike other leukocyte chemoattractants, N-formyl peptides could originate from
Yingying, Le +2 more
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Non-peptide ligands for peptide receptors
Trends in Pharmacological Sciences, 1989Considerable progress has been made in synthesizing peptide analogs with improved stability for probing function of peptide-receptor systems. However, since peptide ligands are usually unsuitable for development as potent orally active long-duration therapeutic agents, considerable research effort is being directed to the development of non-peptidal ...
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Peptide Receptors on Astrocytes
Frontiers in Neuroendocrinology, 1998In recent years, it has become apparent that astrocytes (at least in vitro) harbor functional receptors to almost all possible neurotransmitters (with the potential noticeable exception of acetylcholine nicotinic receptors). Peptides are no exception, since receptors to all neuropeptides known to be produced in the CNS have been found on cultured ...
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Science, 2002
Many small peptides that serve as important signaling molecules have been identified in animals, and more recently similar molecules have been recognized in plants. Matsubayashi et al. have now identified the likely receptor for a sulfated peptide, phytosulfokine, in carrot cells.
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Many small peptides that serve as important signaling molecules have been identified in animals, and more recently similar molecules have been recognized in plants. Matsubayashi et al. have now identified the likely receptor for a sulfated peptide, phytosulfokine, in carrot cells.
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1993
Publisher Summary Natriuretic peptides play a central role in the regulation of body fluid and electrolyte balance. Binding experiments and cross-linking and autoradiographic studies have confirmed the existence of receptors on astrocytes. The dissociation between the binding affinity and cGMP responses remains unexplained.
V.T.F. Yeung +2 more
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Publisher Summary Natriuretic peptides play a central role in the regulation of body fluid and electrolyte balance. Binding experiments and cross-linking and autoradiographic studies have confirmed the existence of receptors on astrocytes. The dissociation between the binding affinity and cGMP responses remains unexplained.
V.T.F. Yeung +2 more
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Vasoactive Peptides and Their Receptors
Journal of Vascular Research, 1990Peptides act as vasoconstrictors (for instance angiotensins, vasopressin) or vasodilators (the kinins, the neurokinins), both through direct activation of specific receptors in the vascular smooth muscles or indirectly through the release of other endogenous inhibitors of the vascular tone.
D, Regoli +4 more
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Receptors for Relaxin Family Peptides
Annals of the New York Academy of Sciences, 2005Abstract: Recent studies have identified four receptors that are the physiological targets for relaxin family peptides. All are class I (rhodopsin like) G‐protein‐coupled receptors with LGR7 (RXFP1) and LGR8 (RXFP2) being type C leucine‐rich repeat‐containing receptors, whereas GPCR135 (RXFP3) and GPCR142 (RXFP4) resemble receptors that respond to ...
Bathgate, R. +4 more
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Non-peptide AT2-receptor agonists
Current Opinion in Pharmacology, 2011The renin-angiotensin-system harbours two main receptor subtypes binding angiotensin II which are the AT1-receptor and the AT2-receptor. While the AT1-receptor has been a drug target in cardiovascular disease for many years, the AT2-receptor was only a subject of academic interest.
U Muscha, Steckelings +8 more
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Peptide hormone and receptor evolution
General and Comparative Endocrinology, 2007An important and fascinating theme that unifies both invertebrate and vertebrate endocrinologists is that of the evolution of peptide precursor and receptor genes. Peptide signalling plays a crucial role in processes that control decisive physiological events in organisms as divergent as yeast and mammals.
Dan, Larhammar, Jozef, Vanden Broeck
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1980
This chapter will critically review attempts to identify receptors for a miscellaneous group of small peptides with apparent multiple roles in the body, only one of which may be that of a neurotransmitter. Most appear to be present in the gut and thus belong to the group of brain-gut peptides (Pearse 1976, 1978).
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This chapter will critically review attempts to identify receptors for a miscellaneous group of small peptides with apparent multiple roles in the body, only one of which may be that of a neurotransmitter. Most appear to be present in the gut and thus belong to the group of brain-gut peptides (Pearse 1976, 1978).
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