Results 31 to 40 of about 1,166,169 (306)

Formyl Peptide Receptor as a Novel Therapeutic Target for Anxiety-Related Disorders [PDF]

, 2014
Formyl peptide receptors (FPR) belong to a family of sensors of the immune system that detect microbe-associated molecules and inform various cellular and sensorial mechanisms to the presence of pathogens in the host.
A Alam, A Strohle, AC Carpenter, AK Sato, AL Stenfeldt, BA Babbin, C Gemperle, C Marquez, C Touma, CA Janeway Jr, CC Wentworth, CC Wentworth, CK Derian, D El Kebir, D Yang, D Yang, DA Christakis, DE Ganella, E Krump, Elisabetta Panza, F Cattaneo, F Miceli, F Sallusto, FA Costa-Pinto, FN Gavins, FN Gavins, Fulvio D'Acquisto, G De Palma, G Taglialatela, Giuseppa Piras, GT Condo, H Lim, H Mou, IA Olsson, IJ Santos-Soto, Irene Gallo, JA Foster, Jeffrey W. Dalley, JF Cryan, JF Cryan, JL Barr, JL Gao, JL Leasure, JP Onnela, JW Jahng, K Chen, K Chen, KL McIlwain, KM Neufeld, L Spurr, LM Sutton, Lorenza Rattazzi, M Antunes, M Aoki, M Bourin, M Bourin, M Keitoku, M Perretti, M Saigo, MA Panaro, Mauro Perretti, MG Gareau, MJ Molloy, MJ Rane, MM van Gaalen, N Benaroya-Milshtein, N Dufton, N Dufton, P Anton, Q Wang, Q Zhang, R Diaz Heijtz, R Luisi, R Medzhitov, RD Ye, RM Deacon, RM Deacon, RM Deacon, RN Walsh, RS Kasai, S Fediuc, S Ihara, S Kedia, S Park, S Pellow, S Riviere, SB Su, SC Heo, SD Liberles, SD Munger, SN Cooray, T Sato, Thomas Gobbetti, Tiziana Rubino, TJ Schoenfeld, V Marashi, Y De, YH Cui, YH Cui   +98 more
core   +11 more sources

Glucose-dependent insulinotropic peptide receptor overexpression in adrenocortical hyperplasia in MEN1 syndrome without loss of heterozygosity at the 11q13 locus

Clinics, 2011
BACKGROUND: The molecular mechanisms involved in the genesis of the adrenocortical lesions seen in MEN1 syndrome (ACL-MEN1) remain poorly understood; loss of heterozygosity at 11q13 and somatic mutations of MEN1 are not usually found in these lesions ...
Marcia Helena Soares Costa, Sorahia Domenice, Rodrigo Almeida Toledo, Delmar Muniz L. Junior, Ana Claudia Latronico, Emilia Modolo Pinto, Sergio Pereira Almeida Toledo, Berenice Bilharinho Mendonca, Maria Candida Barisson Villares Fragoso   +8 more
doaj   +1 more source

Characterisation of the interaction of the C-terminus of the dopamine D2 receptor with neuronal calcium sensor-1. [PDF]

PLoS ONE, 2011
NCS-1 is a member of the neuronal calcium sensor (NCS) family of EF-hand Ca(2+) binding proteins which has been implicated in several physiological functions including regulation of neurotransmitter release, membrane traffic, voltage gated Ca(2 ...
Lu-Yun Lian, Sravan R Pandalaneni, Pryank Patel, Hannah V McCue, Lee P Haynes, Robert D Burgoyne   +5 more
doaj   +1 more source

Selective polypeptide ligand binding to the extracellular surface of the transmembrane domains of the class B GPCRs GLP-1R and GCGR

iScience, 2023
Summary: Crystal and cryo-EM structures of the glucagon-like peptide-1 receptor (GLP-1R) and glucagon receptor (GCGR) bound with their peptide ligands have been obtained with full-length constructs, indicating that the extracellular domain (ECD) is ...
Huixia Wang, Wanhui Hu, Tiandan Xu, Ya Yuan, Dongsheng Liu, Kurt Wüthrich   +5 more
doaj   +1 more source

Gene transfer into hepatocytes using asialoglycoprotein receptor mediated endocytosis of DNA complexed with an artificial tetra-antennary galactose ligand [PDF]

, 1992
We have constructed an artificial ligand for the hepatocyte-specific asialoglycoprotein receptor for the purpose of generating a synthetic delivery system for DNA.
Ashwell G., Atherton E., Atherton E., Baenziger J. U., Christian Plank, Connolly D. T., Corley Cain C., Curiel D. T., DeWet J., Ellman G. L., Ernst Wagner, Gotten M., Gotten M., Gotten M., Huckett B., Karl Mechtler, Kempen H. J. M., Knowles B. B., Kurt Zatloukal, Lee Y. C., Matt Cotten, Orrantia E., Patek P.Q., Rosenkranz A. A., Seifter S., Severne Y., Spiess M., Tam J. P., Wagner E., Wagner E., Wagner E., Wagner E., Wharton S. A., Wu C., Wu G. Y., Zatloukal K., Zenke M.   +36 more
core   +1 more source

De-novo design of complementary (antisense) peptide mini-receptor inhibitor of interleukin 18 (IL-18).

, 2004
Complementary (antisense) peptide mini-receptor inhibitors are complementary peptides designed to be receptor-surrogates that act by binding to selected surface features of biologically important proteins thereby inhibiting protein-cognate receptor ...
Bhakoo, Ashish, Heal, Jonathan R, Keller, Michael, Miller, Andrew D, Raynes, John G   +4 more
core   +1 more source

New modulators for IGF-I activity within IGF-I processing products

Frontiers in Endocrinology, 2013
Insulin-like growth factor I (IGF-I) is a key regulator of muscle development and growth. The pre-pro-peptide produced by the Igf1 gene undergoes several post-translational processing steps to result in a secreted mature protein, which is thought to be ...
Becky Kathleen Brisson, Elisabeth R Barton   +1 more
doaj   +1 more source

Antitumor Strategies Targeting Peptidergic Systems

Encyclopedia
Peptidergic systems show promise as targets for fighting tumors. While some peptides encourage the growth and spread of tumor cells and angiogenic mechanisms, others display antitumor properties. As such, peptide ligands and receptor antagonists could be
Francisco D. Rodríguez, Rafael Coveñas
doaj   +1 more source

The role of C-peptide in regulation of the insulin signaling system (systematic review)

Сибирский научный медицинский журнал, 2021
The C-peptide is a fragment of proinsulin, the cleavage of which forms active insulin. In recent years, new evidence has emerged indicating that C-peptide is involved not only in the processing of insulin in the secretory granules of pancreatic β-cells ...
O. N. Poteryaeva, I. F. Usynin
doaj   +1 more source

Novel skeletal effects of glucagon-like peptide-1 (GLP-1) receptor agonists [PDF]

, 2017
Type 2 diabetes mellitus (T2DM) leads to bone fragility and predisposes to increased risk of fracture, poor bone healing and other skeletal complications.
Chantal Chenu, Guillaume Mabilleau, Iepsen, Iepsen, Marie Pereira   +4 more
core   +5 more sources