Results 51 to 60 of about 1,200,908 (357)

Newly Identified Peptide, Peptide Lv, Promotes Pathological Angiogenesis

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background We recently discovered a small endogenous peptide, peptide Lv, with the ability to activate vascular endothelial growth factor receptor 2 and its downstream signaling.
Liheng Shi, Min Zhao, Colette A. Abbey, Shu‐Huai Tsai, Wankun Xie, Dylan Pham, Samantha Chapman, Kayla J. Bayless, Travis W. Hein, Robert H. Rosa, Michael L. Ko, Lih Kuo, Gladys Y.‐P. Ko   +12 more
doaj   +1 more source

PESIN Conjugates for Multimodal Imaging: Can Multimerization Compensate Charge Influences on Cell Binding Properties? A Case Study

Pharmaceuticals, 2021
Recently, anionic charges were found to negatively influence the in vitro gastrin-releasing peptide receptor (GRPR) binding parameters of dually radioisotope and fluorescent dye labeled GRPR-specific peptide dimers.
Ralph Hübner, Alexa Paretzki, Valeska von Kiedrowski, Marco Maspero, Xia Cheng, Güllü Davarci, Diana Braun, Helen Damerow, Benedikt Judmann, Vasileios Filippou, Clelia Dallanoce, Ralf Schirrmacher, Björn Wängler, Carmen Wängler   +13 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

In Vivo Imaging of Transplanted Islets with ^(64)Cu-DO3A-VS-Cys^(40)-Exendin-4 by Targeting GLP-1 Receptor [PDF]

, 2011
Glucagon-like peptide 1 receptor (GLP-1R) is highly expressed in pancreatic islets, especially on β-cells. Therefore, a properly labeled ligand that binds to GLP-1R could be used for in vivo pancreatic islet imaging.
Bading, James R., Colcher, David, Conti, Peter E., Fraser, Scott E., Ishiyama, Kohei, Kandeel, Fouad, Li, Lin, Li, Zibo, Nair, Indu, Shively, John E., Todorov, Ivan, Wu, Zhanhong   +11 more
core   +2 more sources

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

Systemic GLP-1R agonist treatment reverses mouse glial and neurovascular cell transcriptomic aging signatures in a genome-wide manner

Communications Biology, 2021
Li, Chen, Vong, Zhao et al. show that glucagon-like peptide-1 receptor agonist reverses transcriptomic aging signatures in mouse glial and neurovascular cells.
Zhongqi Li, Xinyi Chen, Joaquim S. L. Vong, Lei Zhao, Junzhe Huang, Leo Y. C. Yan, Bonaventure Ip, Yun Kwok Wing, Hei-Ming Lai, Vincent C. T. Mok, Ho Ko   +10 more
doaj   +1 more source

Rescue with an anti-inflammatory peptide of chickens infected H5N1 avian flu [PDF]

, 2009
Chickens suffering from avian flu caused by H5N1 influenza virus are destined to die within 2 days due to a systemic inflammatory response. Since HVJ infection (1,2) and influenza virus infection (3,4) cause infected cells to activate homologous serum ...
Alan A. Okada, Ekowati E. Handharyani, Hidechika H. Okada, Kazuhide K. Adachi, Masaki M. Imai, Noriko N. Okada, Retno Damajanti R. D. Soejoedono, Yasuhiro Tsukamoto   +7 more
core   +1 more source

Ocean acidification affects marine chemical communication by changing structure and function of peptide signalling molecules [PDF]

, 2016
Ocean acidification is a global challenge that faces marine organisms in the near future with a predicted rapid drop in pH of up to 0.4 units by the end of this century.
Adamo, Bode, Bopp, Briffa, Brown, Browne, Clements, Compton, Crothers, Darnell, Decho, Dodd, Fabry, Forward, Grimme, Grimme, Halgren, Hall-Spencer, Hardege, Hardege, Hay, Hayden, Haye, Hehre, Henry, Hunter, Jensen, Jensen, Jensen, Kim, Klamt, Kratt, Kutzelnigg, Leduc, Lemly, Lide, Lodewyk, McDonald, McNeil, Munday, Munday, Neese, Neese, Nilsson, O'Boyle, Perdew, Pettis, Piotto, Po, Pörtner, R Core Team, Reinsel, Reisert, Rittschof, Rittschof, Rittschof, Rittschof, Sklenář, Steiger, Tegtmeyer, Tierney, Vries, Weigend, Wishart, Wittmann, Wyatt, Wyatt, Wyatt, Zimmer, Zimmer-Faust   +69 more
core   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire [PDF]

, 2012
Idiosyncratic adverse drug reactions are unpredictable, dose independent and potentially life threatening; this makes them a major factor contributing to the cost and uncertainty of drug development. Clinical data suggest that many such reactions involve
A. Lucas, A. M. English, A. Sette, A. Wriston, B. J. Grant, B. Peters, C. A. F. de Oliveira, C. Oseroff, Cahalan, Chessman, Chung, D. A. Ostrov, D. F. Hunt, Day, E. Phillips, Faletto, Friesner, H. M. Grey, H. Mei, Harndahl, J. Jakoncic, J. Shabanowitz, J. Sidney, Ko, L. Shi, L. Yang, Lavergne, M. Harndahl, Mallal, Martin, Melroy, Phillips, Pichler, Rudolph, S. Buus, S. Lu, S. Mallal, S. Southwood, Shastri, Shimizu, Sidney, Sidney, Tenzer, Udeshi, Y. A. Pompeu, Yang, Yang, Yewdell   +47 more
core   +4 more sources