Results 61 to 70 of about 1,166,169 (306)

Exploring the taste presentation and receptor perception mechanism of salty peptides from Stropharia rugosoannulata based on molecular dynamics and thermodynamics simulation

Food Science and Human Wellness
The taste presentation and receptor perception mechanism of the salty peptide of Stropharia rugosoannulata were predicted and verified using peptide omics and molecular interaction techniques.
Wen Li, Shuai Sun, Wanchao Chen, Haile Ma, Tingzhao Li, Zhong Zhang, Di Wu, Mengqiu Yan, Yan Yang   +8 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Molecular recognition of an acyl-peptide hormone and activation of ghrelin receptor

Nature Communications, 2021
Ghrelin is a gastric peptide hormone and its acylation is required for binding to and activation of the ghrelin receptor in the brain, which initiates appetite.
Yue Wang, Shimeng Guo, Youwen Zhuang, Ying Yun, Peiyu Xu, Xinheng He, Jia Guo, Wanchao Yin, H. Eric Xu, Xin Xie, Yi Jiang   +10 more
doaj   +1 more source

Rescue with an anti-inflammatory peptide of chickens infected H5N1 avian flu [PDF]

, 2009
Chickens suffering from avian flu caused by H5N1 influenza virus are destined to die within 2 days due to a systemic inflammatory response. Since HVJ infection (1,2) and influenza virus infection (3,4) cause infected cells to activate homologous serum ...
Alan A. Okada, Ekowati E. Handharyani, Hidechika H. Okada, Kazuhide K. Adachi, Masaki M. Imai, Noriko N. Okada, Retno Damajanti R. D. Soejoedono, Yasuhiro Tsukamoto   +7 more
core   +1 more source

Ocean acidification affects marine chemical communication by changing structure and function of peptide signalling molecules [PDF]

, 2016
Ocean acidification is a global challenge that faces marine organisms in the near future with a predicted rapid drop in pH of up to 0.4 units by the end of this century.
Adamo, Bode, Bopp, Briffa, Brown, Browne, Clements, Compton, Crothers, Darnell, Decho, Dodd, Fabry, Forward, Grimme, Grimme, Halgren, Hall-Spencer, Hardege, Hardege, Hay, Hayden, Haye, Hehre, Henry, Hunter, Jensen, Jensen, Jensen, Kim, Klamt, Kratt, Kutzelnigg, Leduc, Lemly, Lide, Lodewyk, McDonald, McNeil, Munday, Munday, Neese, Neese, Nilsson, O'Boyle, Perdew, Pettis, Piotto, Po, Pörtner, R Core Team, Reinsel, Reisert, Rittschof, Rittschof, Rittschof, Rittschof, Sklenář, Steiger, Tegtmeyer, Tierney, Vries, Weigend, Wishart, Wittmann, Wyatt, Wyatt, Wyatt, Zimmer, Zimmer-Faust   +69 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Overview of Calcitonin Gene-Related Peptide and Its Receptor

The Scientific World Journal, 2001
Calcitonin Gene-Related Peptide (CGRP), a 37 amino acid peptide identified as the alternately spliced gene product of calcitonin gene, is a sensory neuropeptide with potent cardiovascular effects. CGRP is distributed throughout the central and peripheral
Nambi Aiyar
doaj   +1 more source

Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire [PDF]

, 2012
Idiosyncratic adverse drug reactions are unpredictable, dose independent and potentially life threatening; this makes them a major factor contributing to the cost and uncertainty of drug development. Clinical data suggest that many such reactions involve
A. Lucas, A. M. English, A. Sette, A. Wriston, B. J. Grant, B. Peters, C. A. F. de Oliveira, C. Oseroff, Cahalan, Chessman, Chung, D. A. Ostrov, D. F. Hunt, Day, E. Phillips, Faletto, Friesner, H. M. Grey, H. Mei, Harndahl, J. Jakoncic, J. Shabanowitz, J. Sidney, Ko, L. Shi, L. Yang, Lavergne, M. Harndahl, Mallal, Martin, Melroy, Phillips, Pichler, Rudolph, S. Buus, S. Lu, S. Mallal, S. Southwood, Shastri, Shimizu, Sidney, Sidney, Tenzer, Udeshi, Y. A. Pompeu, Yang, Yang, Yewdell   +47 more
core   +4 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

The ENaC taste receptor’s perceived mechanism of mushroom salty peptides revealed by molecular interaction analysis

npj Science of Food
The ENaC receptor acts as a taste receptor to recognize and perceive salty substances. This study explored the mechanisms by which the ENaC taste receptor recognizes and binds mushroom-derived salty peptides using molecular interaction and molecular ...
Wen Li, Wanchao Chen, Di Wu, Zhong Zhang, Peng Liu, Zhengpeng Li, Yan Yang   +6 more
doaj   +1 more source