Results 101 to 110 of about 18,455 (220)

Programming Next‐Generation Synthetic Biosensors by Genetic Circuit Design

Advanced Science, Volume 13, Issue 14, 9 March 2026.
Synthetic biology enables genetic circuit‐based biosensing to detect diverse targets, process signals, and transduce them into readable outputs or intracellular regulatory activities. However, field deployment and real‐world application of such synthetic biosensors face considerable challenges in sensitivity, specificity, speed, stability, and ...
Yuanli Gao, Cheng Huang, Jiaxuan Deng, Lei Wang, Baojun Wang   +4 more
wiley   +1 more source

Initial clinical experience with 68Ga-DOTA-NOC prepared using 68Ga from nanoceria-polyacrylonitrile composite sorbent-based 68Ge/68Ga generator and freeze-dried DOTA-NOC kits

World Journal of Nuclear Medicine, 2017
Somatostatin receptor positron emission tomography–computed tomography (PET/CT) with 68Ga-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) peptides have become an indispensable part of disease assessment in patients with neuroendocrine ...
Piyush Chandra, Bhakti Shetye, Rubel Chakravarty, Archana Mukherjee, Usha Pandey, Ashish Jha, Nilendu Purandare, Sneha Shah, Archi Agrawal, Ramu Ram, Ashutosh Dash, Venkatesh Rangarajan   +11 more
doaj   +1 more source

Study of the impact of tissue density heterogeneities on 3-dimensional abdominal dosimetry: comparison between dose kernel convolution and direct monte carlo methods. [PDF]

, 2012
Dose kernel convolution (DK) methods have been proposed to speed up absorbed dose calculations in molecular radionuclide therapy. Our aim was to evaluate the impact of tissue density heterogeneities (TDH) on dosimetry when using a DK method and to ...
Baechler, S., Boubaker, A., Dieudonné, A., Gardin, I., Hobbs, R.F., Le Guludec, D., Lebtahi, R., Maurel, F., Sgouros, G., Wahl, R.L.   +9 more
core   +2 more sources

Tumour‐targeted fluorescence‐guided surgery in gastrointestinal cancer: A systematic review of preclinical and clinical research

Clinical and Translational Medicine, Volume 16, Issue 3, March 2026.
Tumour‐targeted fluorescence‐guided surgery (Ttfgs) enhances intraoperative precision in gastrointestinal cancer treatment. Translation of (Ttfgs) into clinical practice is limited by heterogeneity, regulatory hurdles, biomarker variability and absence of phase III trials.
Aaya Darai, Evie H. M. Graus, Femke J. A. van der Stroom, Mark Rijpkema, Alexander Vahrmeijer, Denise E. Hilling, Johannes H. W. De Wilt, Merlijn Hutteman   +7 more
wiley   +1 more source

Illuminating Glucose: How to Unveil Organ‐Specific Insulin Resistance and Guide Metabolic Strategies in Diabetes

Diabetes/Metabolism Research and Reviews, Volume 42, Issue 3, March 2026.
ABSTRACT Recent evidence has shown that muscle insulin resistance is not the only factor contributing to type 2 diabetes (T2D). Organ‐specific insulin resistance is increasingly recognised as a significant contributor to the metabolic changes that lead to hyperglycemia, although the precise extent of its impact remains unclear.
Shawn Gugliandolo, Cassandra Morciano, Lucia Leccisotti, Umberto Capece, Gianfranco Di Giuseppe, Teresa Mezza, Gea Ciccarelli, Laura Soldovieri, Michela Brunetti, Adriana Avolio, Amelia Splendore, Alfredo Pontecorvi, Andrea Giaccari, Francesca Cinti   +13 more
wiley   +1 more source

Early response assessment and prediction of overall survival after peptide receptor radionuclide therapy

Cancer Imaging, 2020
Background Response after peptide receptor radionuclide therapy (PRRT) can be evaluated using anatomical imaging (CT/MRI), somatostatin receptor imaging ([68Ga]Ga-DOTA-TATE PET/CT), and serum Chromogranin-A (CgA).
Daphne M. V. Huizing, Else A. Aalbersberg, Michelle W. J. Versleijen, Margot E. T. Tesselaar, Iris Walraven, Max J. Lahaye, Berlinda J. de Wit–van der Veen, Marcel P. M. Stokkel   +7 more
doaj   +1 more source

Neodymium-140 DOTA-LM3:Evaluation of an In Vivo Generator for PET with a Non-Internalizing Vector [PDF]

, 2017
140Nd (t1/2 = 3.4 days), owing to its short-lived positron emitting daughter 140Pr (t1/2 = 3.4 min), has promise as an in vivo generator for positron emission tomography (PET).
Anders F. Frellsen, Andreas I. Jensen, Andreas Kjær, Carsten H. Nielsen, Dennis R. Elema, Gregory W. Severin, Gregory W. Severin, Gregory W. Severin, Helmut Maecke, Jesper Fonslet, K. M. Jensen, Karl Johnston, Lotte K. Kristensen, Ulli Köster, Ulli Köster   +14 more
core   +3 more sources

Iodine-131 labelled octreotide: Not an option for somatostatin receptor therapy [PDF]

, 1996
Gamma-emitting radiopeptides are useful for scintigraphy of tumours on the basis of receptor binding. Likewise, β-emitting radiopeptides may be used in radionuclide therapy of such tumours.
Bakker, W.H. (Willem), Breeman, W.A.P. (Wouter), Jong, M. (Marcel) de, Krenning, E.P. (Eric), Pluijm, M. (M.) van der, Visser, T.J. (Theo)   +5 more
core   +1 more source

Meeting Notes of the Taiwan Neuroendocrine Tumor Society & Taiwan Society of Nuclear Medicine Joint Conference - Peptide Receptor Radionuclide Therapy Targeting for Gastroenteropancreatic Neuroendocrine Tumors: Basic Principles and State-of-the-art Clinical Practice

Journal of Cancer Research and Practice
Objective: The current study aimed to investigate the basic principles and clinical applications, including the selection of proper candidates, follow-up strategies, and radiation protection issues relating to peptide receptor radionuclide therapy (PRRT).
Mei-Fang Cheng, Chih-Chieh Yen, Jeng-Shiun Du, Yu-Li Chiu, Ming-Huang Chen, Hui-Jen Tsai, I-Chen Wu, Hueng-Yuan Shen, Ruoh-Fang Yen, Li-Tzong Chen, On Behalf of Taiwan Neuroendocrine Tumor Society and Taiwan Society of Nuclear Medicine   +10 more
doaj   +1 more source

177Lu-DOTATATE peptide receptor radionuclide therapy in metastatic or advanced and inoperable primary neuroendocrine tumors of rare sites

World Journal of Nuclear Medicine, 2017
The present study aimed at exploring the patient and imaging characteristics of primary neuroendocrine tumors (NETs) of rare sites who presented with metastatic and/or advanced inoperable stages and therefore was considered for peptide receptor ...
Pradeep Thapa, Rahul Parghane, Sandip Basu   +2 more
doaj   +1 more source